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Original papers

2019

Takahashi K, Hayashi S, Miyajima M, Omori M, Wang J, Kaihara K, Morimatsu M, Wang C, Chen J, Iribe G, Naruse K, Sokabe M. L-type calcium channel modulates mechanosensitivity of the cardiomyocyte cell line H9c2. Cell Calcium 79: 68-74 (2019) doi: 10.1016/j.ceca.2019.02.008.

 

2018

Katanosaka K, Takatsu S, Mizumura K, Naruse K, Katanosaka Y. TRPV2 is required for mechanical nociception and the stretch-evoked response of primary sensory neurons. Sci Rep 8(1):16782(2018) doi: 10.1038/s41598-018-35049-4.

 

Hirano K, Iwaki T, Ishido T, Yoshikawa Y, Naruse K, Yoshikawa K. Stretching of single DNA molecules caused by accelerating flow on a microchip. J Chem Phys 149(16):165101(2018) doi: 10.1063/1.5040564.

 

Asano S, Ito S, Morosawa M, Furuya K, Naruse K, Sokabe M, Yamaguchi E, Hasegawa Y. Cyclic stretch enhances reorientation and differentiation of 3-D culture model of human airway smooth muscle. Biochem Biophys Rep 16:32-38(2018) doi: 10.1016/j.bbrep.2018.09.003.

 

Matsuda Y, Takahashi K, Kamioka H, Naruse K. Human gingival fibroblast feeder cells promote maturation of induced pluripotent stem cells into cardiomyocytes. Biochem Biophys Res Commun 503(3):1798-1804 (2018) doi: 10.1016/j.bbrc.2018.07.116.

 

Yamaguchi Y, Iribe G, Kaneko T, Takahashi K, Numaga-Tomita T, Nishida M, Birnbaumer L, Naruse K. TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes. J Physiol Sci 8(2):153-164 (2018) doi: 10.1007/s12576-016-0519-3.

 

Khokhlova A, Iribe G, Katsnelson L, Naruse K, Solovyova O. The effects of load on transmural differences in contraction of isolated mouse ventricular cardiomyocytes. J Mol Cell Cardiol 114:276-287 (2018) doi: 10.1016/j.yjmcc.2017.12.001.

 

2017

Iribe G, Kaihara K, Yamaguchi Y, Nakaya M, Inoue R, Naruse K. Mechano-sensitivity of mitochondrial function in mouse cardiac myocytes. Prog Biophys Mol Biol 130(Pt B):315-322 (2017) doi: 10.1016/j.pbiomolbio.2017.05.015.

 

Yamaguchi Y, Iribe G, Nishida M, Naruse K Role of TRPC3 and TRPC6 channels in the myocardial response to stretch: Linking physiology and pathophysiology. Prog Biophys Mol Biol. 130(Pt B):264-272(2017) doi: 10.1016/j.pbiomolbio.2017.06.010.

 

Khokhlova A, Iribe G, Yamaguchi Y, Naruse K, Solovyova O. Effects of simulated ischemia on the transmural differences in the Frank-Starling relationship in isolated mouse ventricular cardiomyocytes. Prog Biophys Mol Biol 130(Pt B):323-332 (2017) doi: 10.1016/j.pbiomolbio.2017.05.011.

 

Jin H, Iribe G, Naruse K. Effects of bepridil on stretch-activated BKca channels and stretch-induced extrasystoles in isolated chick hearts. Physiol Res 66(3): 459-465 (2017)

 

2016

Ujihara Y, Iwasaki K, Takatsu S, Hashimoto K, Naruse K. Mohri S, Katanosaka Y. Induced NCX1 overexpression attenuates pressure overload-induced pathological cardiac remodelling. Cardiovasc Res 111(4): 348-61 (2016).

 

Takahashi K, Matsuda Y, Naruse K. Mechanosensitive ion channels. AIMS Biophysics 2016; 3(1): 63-74.

 

2015

Yamada A, Mohri S, Nakamura M, Naruse K. A simple method for decreasing the liquid junction potential in a flow-through-type differential pH sensor probe consisting of pH-FETs by exerting spatiotemporal control of the liquid junction. Sensors (Basel) 15(4): 7898-7912 (2015).

 

Tokuyama E, Nagai Y, Takahashi K, Kimata Y, Naruse K. Mechanical Stretch on Human Skin Equivalents Increases the Epidermal Thickness and Develops the Basement Membrane. PLoS One 10(11): e0141989 (2015).

 

Piao H, Takahashi K, Yamaguchi Y, Wang C, Liu K, Naruse K. Transient Receptor Potential Melastatin-4 Is Involved in Hypoxia-Reoxygenation Injury in the Cardiomyocytes. PLoS One 10(4): e0121703 (2015).

 

2014

Murata N, Ito S, Furuya K, Takahara N, Naruse K, Aso H, Kondo M, Sokabe M, Hasegawa Y. Ca2+ influx and ATP release mediated by mechanical stretch in human lung fibroblasts. Biochem Biophys Res Commun 453(1): 101-105 (2014).

 

Takahara N, Ito S, Furuya K, Naruse K, Aso H, Kondo M, Sokabe M, Hasegawa Y. Real-time imaging of ATP release induced by mechanical stretch in human airway smooth muscle cells. Am J Respir Cell Mol Biol 51(6): 772-82 (2014).

 

Komatsu S, Nagai Y, Naruse K, Kimata Y. The Neutral Self-Assembling Peptide Hydrogel SPG-178 as a Topical Hemostatic Agent. PLoS One 9(7): e102778 (2014).

 

Kobayashi J, Yoshida M, Tarui S, Hirata M, Nagai Y, Kasahara S, Naruse K, Ito H, Sano S, Oh H. Directed Differentiation of Patient-Specific Induced Pluripotent Stem Cells Identifies the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 in Hypoplastic Left Heart Syndrome. PLoS One 9: e102796 (2014).

 

Iribe G, Kaneko T, Yamaguchi Y, Naruse K. Load dependency in force-length relations in isolated single cardiomyocytes. Prog Biophys Mol Biol 115(2-3): 103-114 (2014).

 

Igarashi J, Hashimoto T, Kubota Y, Shoji K, Maruyama T, Sakakibara N, Takuwa Y, Ujihara Y, Katanosaka Y, Mohri S, Naruse K, Yamashita T, Okamoto R, Hirano K, Kosaka H, Takata M, Konishi R, Tsukamoto I. Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells. Pharmacology Research & Perspectives 2(5) (2014).

 

Katanosaka Y, Iwasaki K, Ujihara Y, Takatsu S, Nishitsuji K, Kanagawa M, Sudo A, Toda T, Katanosaka K, Mohri S, Naruse K. TRPV2 is critical for the maintenance of cardiac structure and function in mice. Nat Commun 5: 3932 (2014)

 

Matsuura K, Chen K-H, Tsai C-H, Li W, Asano Y, Naruse K, Cheng C-M. Paper-based diagnostic devices for evaluating the quality of human sperm. Microfluidics and Nanofluidics 16(5): 857-867 (2014).

 

Takahashi K, Oda T, Naruse K. Coarse-grained molecular dynamics simulations of biomolecules. AIMS Biophysics 1(1): 1-15 (2014).


2013

Kanagawa M, Yu CC, Ito C, Fukada S, Hozoji-Inada M, Chiyo T, Kuga A, Matsuo M, Sato K, Yamaguchi M, Ito T, Ohtsuka Y, Katanosaka Y, Miyagoe-Suzuki Y, Naruse K, Kobayashi K, Okada T, Takeda S, Toda T. Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression. Hum Mol Genet 22(15): 3003-3015 (2013).

 

Matsuura K, Mizuki K, Yusuke N, Naruse K. Synthesis and Slow-Release Characteristics of a Self-Assembling Peptide Gel Containing Phenylalanine Azide. Recent Patents on Nanomedicine 3(2): 140-145 (2013).

 

Shibata AC, Chen LH, Nagai R, Ishidate F, Chadda R, Miwa Y, Naruse K, Shirai YM, Fujiwara TK, Kusumi A. Rac1 recruitment to the archipelago structure of the focal adhesion through the fluid membrane as revealed by single-molecule analysis. Cytoskeleton (Hoboken) 70(3): 161-177 (2013).

 

Matsuura K, Asano Y, Yamada A, Naruse K. Detection of Micrococcus luteus biofilm formation in microfluidic environments by pH measurement using an ion-sensitive field-effect transistor. Sensors (Basel) 13(2): 2484-2493 (2013).

 

Ishihara Y, Sugawara Y, Kamioka H, Kawanabe N, Hayano S, Balam TA, Naruse K, Yamashiro T. Ex vivo real-time observation of Ca(2+) signaling in living bone in response to shear stress applied on the bone surface. Bone 53(1): 204-215 (2013).

 

Hara T, Matsuura K, Kodama T, Sato K, Kikkawa Y, Muneto T, Tanaka J, Naruse K. A tilting embryo culture system increases the number of high-grade human blastocysts with high implantation competence. Reprod Biomed Online 26(3): 260-268 (2013).

 

Hata M, Naruse K, Ozawa S, Kobayashi Y, Nakamura N, Kojima N, Omi M, Katanosaka Y, Nishikawa T, Naruse K, Tanaka Y, Matsubara T. Mechanical stretch increases the proliferation while inhibiting the osteogenic differentiation in dental pulp stem cells. Tissue Eng Part A 19(5-6): 625-633 (2013).

 

Wang J*, Takahashi K* (*: equal contribution), Piao H, Qu P, Naruse K.9-phenanthrol, a TRPM4 inhibitor, protects isolated rat hearts from ischemia–reperfusion injury. PLoS One 8(7): e70587 (2013).


Iribe G, Kaihara K, Ito H, Naruse K. Effect of azelnidipine and amlodipine on single cell mechanics in mouse cardiomyocytes. Eur J Pharmacol (2013).


Takahashi K, Kakimoto Y, Toda K, Naruse K. Mechanobiology in cardiac physiology and diseases. J Cell Mol Med 17(2): 225-32 (2013).


2012

Takahashi K, Naruse K. Stretch-activated BK channel and heart function. Prog Biophys Mol Biol 110(2-3): 239-244 (2012).

 

Shibata AC, Fujiwara TK, Chen L, Suzuki KG, Ishikawa Y, Nemoto YL, Miwa Y, Kalay Z, Chadda R, Naruse K, Kusumi A. Archipelago architecture of the focal adhesion: membrane molecules freely enter and exit from the focal adhesion zone. Cytoskeleton (Hoboken) 69(6): 380-392 (2012).

 

Ishihara Y, Sugawara Y, Kamioka H, Kawanabe N, Kurosaka H, Naruse K, Yamashiro T. In situ imaging of the autonomous intracellular Ca(2+) oscillations of osteoblasts and osteocytes in bone. Bone 50(4): 842-852 (2012).

 

Nagai Y, Yokoi H, Kaihara K, Naruse K. The mechanical stimulation of cells in 3D culture within a self-assembling peptide hydrogel. Biomaterials 33(4): 1044-51 (2012).


Matsuura K, Takenami M, Kuroda Y, Hyakutake T, Yanase S, Naruse K. Screening of sperm velocity by fluid mechanical characteristics of a cyclo-olefin polymer microfluidic sperm-sorting device. Reprod Biomed Online 24(1): 109-15 (2012).


2011

Morioka M, Parameswaran H, Naruse K, Kondo M, Sokabe M, Hasegawa Y, Suki B, Ito S. Microtubule dynamics regulate cyclic stretch-induced cell alignment in human airway smooth muscle cells. Plos One 6(10): e26384 (2011).


Yamada A, Mohri S, Nakamura M, Naruse K. Glucose Dependency of the Metabolic Pathway of HEK 293 Cells Measured by a Flow-through Type pH/CO2 Sensor System Using ISFETs. IEEJ Trans Electr Electron Eng, Informaiton and Systems 131(9): 1535-1539 (2011).


Iribe G, Jin H, Naruse K. Role of Sarcolemmal BK(Ca) Channels in Stretch-Induced Extrasystoles in Isolated Chick Hearts. Circ J 75(11): 2552-8 (2011).


Takata N, Furumatsu T, Abe N, Naruse K, Ozaki T. Comparison between loose fragment chondrocytes and condyle fibrochondrocytes in cellular proliferation and redifferentiation. J Orthop Sci 16(5): 589-97 (2011).


Tetsunaga T, Nishida K, Furumatsu T, Naruse K, Hirohata S, Yoshida A, Saito T, Ozaki T. Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells. Osteoarthritis Cartilage 19 (2), 222-232 (2011).


2010

Kubota R, Numaguchi Y, Ishii M, Niwa M, Okumura K, Naruse K, Murohara T. Ischemia-induced angiogenesis is impaired in aminopeptidase A deficient mice via down-regulation of HIF-1alpha. Biochem Biophys Res Commun 402 (2), 396-401 (2010).

 

Koike T, Matsuura K, Naruse K, Funahashi H. In-vitro culture with a tilting device in chemically defined media during meiotic maturation and early development improves the quality of blastocysts derived from in-vitro matured and fertilized porcine oocytes. J Reprod Dev 56 (5), 552-557 (2010).

 

Sano H, Matsuura K, Naruse K, Funahashi H. Application of a microfluidic sperm sorter to the in-vitro fertilization of porcine oocytes reduced the incidence of polyspermic penetration. Theriogenology 74 (5), 863-870 (2010).

 

Iribe G, Jin H, Kaihara K, Naruse K. Effects of axial stretch on sarcolemmal BKCa channels in post-hatch chick ventricular myocytes. Exp Physiol 95 (6), 699-711 (2010).

 

Yamada A, Mohri S, Nakamura M, Naruse K. A fully automated pH measurement system for 96-well microplates using a semiconductor-based pH sensor. Sensors and Actuators B-Chemical 143 (2), 464-469 (2010).

 

Matsuura K, Hayashi N, Takiue C, Hirata R, Habara T, Naruse K. Blastocyst quality scoring based on morphologic grading correlates with cell number. Fertil Steril 94 (3), 1135-1137 (2010).


Matsuura K, Hayashi N, Kuroda Y, Takiue C, Hirata R, Takenami M, Aoi Y, Yoshioka N, Habara T, Mukaida T, Naruse K. Improved development of mouse and human embryos using a tilting embryo culture system. Reprod Biomed Online 20 (3), 358-364 (2010).


Yamada A, Mohri S, Nakamura M, Naruse K. Optimizing the conditions for pH measurement with an automated pH measurement system using a flow-through-type differential sensor probe consisting of pH-FETs. Journal of Robotics and Mechatronics 22 (2), 197-203 (2010).


Ito S, Suki B, Kume H, Numaguchi Y, Ishii M, Iwaki M, Kondo M, Naruse K, Hasegawa Y, Sokabe M. Actin cytoskeleton regulates stretch-activated Ca2+ influx in human pulmonary microvascular endothelial cells. Am J Respir Cell Mol Biol 43 (1), 26-34 (2010).

 

2009

Cheng CM, Matsuura K, Wang IJ, Kuroda Y, Leduc PR, Naruse K. Fabricating small-scale, curved, polymeric structures with convex and concave menisci through interfacial free energy equilibrium. Lab on a Chip 9(22): 3306-3309 (2009).


Hyakutake T, Hashimoto Y, Yanase S, Matsuura K, Naruse K. Application of a numerical simulation to improve the separation efficiency of a sperm sorter. Biomed Microdevices 11(1): 25-33 (2009).


Ishii M, Numaguchi Y, Okumura K, Kubota R, Ma X, Murakami R, Naruse K, Murohara T. Mesenchymal stem cell-based gene therapy with prostacyclin synthase enhanced neovascularization in hindlimb ischemia. Atherosclerosis 206(1): 109-118 (2009).


Iwaki M, Ito S, Morioka M, Iwata S, Numaguchi Y, Ishii M, Kondo M, Kume H, Naruse K, Sokabe M, Hasegawa Y. Mechanical stretch enhances IL-8 production in pulmonary microvascular endothelial cells. Biochem Biophys Res Commun 389(3): 531-536 (2009).


Mochizuki T, Sokabe T, Araki I, Fujishita K, Shibasaki K, Uchida K, Naruse K, Koizumi S, Takeda M, Tominaga M. The TRPV4 Cation Channel Mediates Stretch-evoked Ca2+ Influx and ATP Release in Primary Urothelial Cell Cultures. Journal of Biological Chemistry 284(32): 21257-21264 (2009).


Naruse K, Suemori T, Morimatsu H, Mizobuchi S, Morita K, Katanosaka Y, Mohri S. Impairment of leukocyte deformability in patients undergoing esophagectomy. Clinical Hemorheology and Microcirculation 41(2): 127-136 (2009).


Naruse K, Tang QY, Sokabe M. Stress-Axis Regulated Exon (STREX) in the C terminus of BK(Ca) channels is responsible for the stretch sensitivity. Biochem Biophys Res Commun 385(4): 634-639 (2009).


Naruse K, Yamada A, Katanosaka Y, Mohri S. A Rapid Microfluidic Switching System for Analysis at the Single Cellular Level. Ieee Transactions on Nanobioscience 8(4): 306-311 (2009).


Suzuki S, Iwata M, Hayakawa K, Inoue T, Naruse K. Uniaxial Cyclic Stretch Increases Glucose Uptake into C2C12 Myotubes through a Signaling Pathway Independent of Insulin-like Growth Factor I. Hormone and Metabolic Research 41(1): 16-22 (2009).


Tetsunaga T, Furumatsu T, Abe N, Nishida K, Naruse K, Ozaki T. Mechanical stretch stimulates integrin alphaVbeta3-mediated collagen expression in human anterior cruciate ligament cells. J Biomech 42(13): 2097-2103 (2009).


Yamada A, Katanosaka Y, Mohri S, Naruse K. A Rapid Microfluidic Switching System for Analysis at the Single Cellular Level. Ieee Transactions on Nanobioscience 8(4): 306-311 (2009).


2008

Ando J, Shimizu N, Yamamoto K, Obi S, Kumagaya S, Masumura T, Shimano Y, Naruse K, Yamashita J.K, Igarashi T. Cyclic strain induces mouse embryonic stem cell differentiation into vascular smooth muscle cells by activating PDGF receptor beta. Journal of Applied Physiology 104 (3), 766-772 (2008).


Yasui F, Miyazu M, Yoshida A, Naruse K, Takai A. Examination of signalling pathways involved in muscarinic responses in bovine ciliary muscle using YM-254890, an inhibitor of the Gq/11 protein. Br J Pharmacol 154 (4) 890-900 (2008).


Hirano, Y. Ishiguro, N. Sokabe, M. Takigawa, M. Naruse, K. Effects of tensile and compressive strains on response of a chondrocytic cell line embedded in type I collagen gel. J Biotechnol 133 (2) 245-252 (2008).


Katanosaka, Y. Bao, J.H. Komatsu, T. Suemori, T. Yamada, A. Mohri, S, Naruse, K. Analysis of cyclic-stretching responses using cell-adhesion-patterned cells. Journal of Biotechnology 133 (1) 82-89 (2008).


Ito, S. Kume, H. Naruse, K. Kondo, M. Takeda, N. Iwata, S. Hasegawa, Y. Sokabe, M. A novel Ca2+ influx pathway activated by mechanical stretch in human airway smooth muscle cells. Am J Respir Cell Mol Biol 38 (4) 407-413 (2008).


2007

Kajiya, M. Hirota, M. Inai, Y. Kiyooka, T. Morimoto, T. Iwasaki, T. Endo, K. Mohri, S. Shimizu, J. Yada, T. Ogasawara, Y. Naruse, K. Ohe, T. Kajiya, F. Impaired NO-mediated vasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats. Am J Physiol Heart Circ Physiol 292 (6) H2737-2744 (2007).


Iwata, M. Hayakawa, K. Murakami, T. Naruse, K. Kawakami, K. Inoue-Miyazu, M. Yuge, L. Suzuki, S. Uniaxial cyclic stretch-stimulated glucose transport is mediated by a ca-dependent mechanism in cultured skeletal muscle cells. Pathobiology 74 (3) 159-168 (2007).


Mohri, S. Nakamura, M. K, N. Automation of pH measurement using a flow-through type differential pH sensor system based on pH-FET. IEEJ Trans SM 127 (8) 367-370 (2007).


2006

Takeda, H. Komori, K. Nishikimi, N. Nimura, Y. Sokabe, M. Naruse, K. Bi-phasic activation of eNOS in response to uni-axial cyclic stretch is mediated by differential mechanisms in BAECs. Life Sci 79 (3) 233-239 (2006).


Ito, S. Majumdar, A. Kume, H. Shimokata, K. Naruse, K. Lutchen, K.R. Stamenovic, D. Suki, B. Viscoelastic and dynamic nonlinear properties of airway smooth muscle tissue: roles of mechanical force and the cytoskeleton. Am J Physiol Lung Cell Mol Physiol 290 (6) L1227-1237 (2006).


Ito, S. Kume, H. Oguma, T. Ito, Y. Kondo, M. Shimokata, K. Suki, B. Naruse, K. Roles of stretch-activated cation channel and Rho-kinase in the spontaneous contraction of airway smooth muscle. Eur J Pharmacol 552 (1-3) 135-142 (2006).


Book chapters

2016

Takahashi K, Naruse K. Dynamic remodeling of the heart and blood vessels: implications of health and disease. In: Rawlinson S (Ed.), Mechanobiology: Exploitation for Medical Benefit. pp.175-189, Wiley-Blackwell, 2016. ISBN: 978-1-118-96614-3


Takahashi K, Piao H, Naruse K. Innovation of vascular engineering by mechano-medicine. In: Tanishita K, Yamamoto K (Eds.), Vascular Engineering: New Prospects of Vascular Medicine and Biology with a Multidiscipline Approach. pp.283-296, Springer Japan, Tokyo, 2016. ISBN: 978-4-431-54800-3



Review articles

2018

Wang C, Naruse K, Takahashi K. Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology. Cells 7(6). pii: E62 (2018) doi: 10.3390/cells7060062.


2017

Takahashi K, Okumura H, Guo R, Naruse K. Effect of Oxidative Stress on Cardiovascular System in Response to Gravity. Int J Mol Sci 4;18(7). pii: E1426 (2017) doi: 10.3390/ijms18071426.


2016

高橋賢, 成瀬恵治. 力学刺激に応答する循環器系の恒常性. Clinical Calcium 26(12): 21-26 (2016).


高橋賢. メカノセンサー. 岡山医学会雑誌 128(1), 61-62 (2016).


2015

高橋賢, 成瀬恵治. iPS治療とメカニカルストレス. ファルマシア 51(11), 1038-1041 (2015).


2014

松浦宏治, 成瀬恵治. 生殖医療・育種デバイス. 生物工学会誌 92(4): 180-183 (2014).


高橋賢, 成瀬恵治心臓・血管の組織工学と再生医療人工臓器 43, 206-208 (2014).


2011

高橋賢, 成瀬恵治. 細胞伸展培養. Surgery Frontier 18(2): 59-63 (2011).


松浦宏治, 成瀬恵治. Dynamic Culture Systemによる受精卵発育促進とその機構解明. Journal of Mammalian Ova Research 28174-179 (2011).


2010

片野坂友紀, 成瀬恵治. 新しい伸展刺激負荷方法を用いたメカノトランスダクション研究. 血管医学 11(4): 301-306 (2010).

 

Katanosaka Y, Naruse K. Musculoskeletal rehabilitation and bone. A novel approach to mechanotransduction using cell-adhesion-patterned cells. Clin Calcium 20(4): 514-519 (2010).

 

Naruse K. Mechanobiology and Medicine. Nano bio-Interfaces in Relation to Molecular Mobility (79-88): (2010).


2007

成瀬恵治. ソフトリソグラフィーを用いた細胞研究・医療用チップの開発. 表面科学 28(4): 204-210 (2007).

 

成瀬恵治. 細胞力覚とロボティクス. 日本ロボット学会誌 25(2): 25-31 (2007).

 

成瀬恵治. 細胞研究・医療チップ. バイオインダストリー 24(2): 25-36 (2007).



Grants awarded

期 間 名 称 課 題 名 区分
H30-32 MOD 防衛装備庁 (旧:技術研究本部) 研究開発事業 安全保障技術研究推進制度 小規模研究課題C(タイプC) メカニカルストレス負荷システムの開発 代表
H27-31 新学術領域研究 重力変化を含む力学的ストレスに対するメカノセンシング機構 領域代表
H26-30 基盤研究(S) メカノメディスン:メカノ医工学を駆使した再生医療・生殖医療への展開 代表
H23-24挑戦的萌芽研究自己集合性ペプチドゲルを用いた3次元培養ストレッチシステムの開発 代表
H23-25基盤研究(B)関節破壊を制御する転写因子とマイクロRNAの誘導機構とその治療応用分担
H22-24基盤研究(A)医工学的解析に基づく生体機械受容システムの分子的基盤と生理学的意義の解明代表
H22-24基盤研究(C)軟骨内骨化過程におけるメカノセンサーTRPV4チャネルの役割に関する研究連携
H22-26文科省特別経費ソフトフルードアクチュエータの研究推進プロジェクト分担
H21-22A-STEP(発掘タイプ・起業検証)生殖補助医療における施術支援マイクロチップデバイス開発と製品化分担
H21文科省支援事業マイクロ空圧アクチュエータを用いた受精卵負荷システムの開発と培養成績 代表
H21-23基盤研究(B)マルチレベル医工学評価法に基つ?く心筋メカノセンサーの作動機序と病態生理的役割分担
H21-22挑戦的萌芽研究医工学的解析に基つ?く肺ストレッチセンサーを介した肺癌発症機構の解明分担
H21基盤研究(B)細胞膜を破壊する蛋白質・ペプチドと膜の相互作用の単一巨大リポソーム法による研究連携
H20-22基盤研究(B)冠循環・心臓メカニクス連関:分子進化から心機能、心不全発症機構までの医工学的解析分担
H20-21特定領域研究単離心筋機械負荷操作を用いた心臓の機械電気相互作用の統合生理研究連携
H20-22基盤研究(B)ヒト心筋細胞の興奮収縮連関制御における機械的負荷の役割連携
H20-22基盤研究(B)関節炎におけるアグリカナーゼ制御機構と変形性関節症早期診断・関節保護治療への応用分担
H19-21基盤研究(A)心不全発症における機械負荷様式の多様性?機械受容分子応答機構と新規治療開発代表
H19-20基盤研究(C)ムスカリン受容体作動性陽イオンチャネルとその調節系の分子実体解明分担
H19学内COE研究支援経費ナノメディスン創成のための研究拠点形成代表
H19-21BBSRC Japan Partnering AwardCardiac Electro-Mechanical Function: Cell-Organ Cross-Talk Revealed via Integration of Experiments and Models分担
H18-22NIH grant R01
(共同研究)
Role of Mechanical Forces in the Progression of Emphysema(末期肺気腫の進行メカニズム)代表
H18-20都市エリア産学官連携促進事業ハプティックによる卵子及び細胞培養組織のバイオクオリティ統合管理システムの開発と応用分担
H18-19基盤研究(B)新規アグリカナーゼの関節炎早期における誘導メカニズムとその役割・診断的応用分担
H18学内COE研究支援経費細胞社会学の拠点形成:-『細胞間の連携』と『周囲環境』の分子生命科学-分担
H18学内COE研究支援経費ナノメディスン創成のための研究拠点形成代表
H17-21特定領域研究マルチスケール操作によるシステム細胞工学:ソフトリソグラフィーを駆使したメカノバイオロジーの研究代表
H17-19NEDO大学発事業創出実用化研究開発事業 ストレッチ刺激負荷3次元培養システムの開発代表
H17-18萌芽研究長期継代培養細胞を用いた視細胞イオンチャネル異常疾患研究のための実験系構築 分担
H17-18萌芽研究新規微量プロテインフォスファターゼ群の分子クローニングと機能解析分担
H17-18基盤研究(A)光駆動ナノメカトロニクスの提案開発分担

Patents

取得済み patented

登録日 公開番号 名 称
17/01/20 特許第6074860号 細胞培養器
17/01/13 特許第6073125号 虚血性心疾患の予防又は治療剤
12/01/13特許第4899051号平面パッチクランプ用支持体の製造方法
11/01/07特許第4654432号機械受容(Stretch Activated)チャネルの活性化抑制剤
10/11/05特許第4620804号自己組織化ペプチドおよび高強度ペプチドゲル
10/02/12特許第4452843号pHまたは濃度の測定装置及びpHまたは濃度の測定方法

出願中 applied

出願日 出願番号 名 称
10/12/24特願2010-287249高強度ペプチドゲル
07/07特願2007-194968 卵細胞の培養装置及びその装置
04/09/28特願2004-281852Cペプチド特異的結合分子及びその用途
04/03/19特願2004-079932培養器用保持装置
02/09/06特願2002-261791カルシウム依存性カリウム透過性機械受容チャネルタンパク質およびその遺伝子
02/03/21特願2002-527230Differential treatment of selected parts of a single cell with different fluid components