Link To International Asidan Symposium 2016 page

In English 简体中文


欢迎光临冈山大学医学部神经内科网页



冈大神经内科目前主要从事三个方面的研究。第一:利用动物模型,对缺血性脑卒中进行基因和干细胞的实验性治疗和研究。我们在世界上首次开发出神经保护药物edaravone并率先应用于对脑卒中患者的治疗,目前正在进行第二代神经保护药物的开发研究,并且期待在不远的将来,这项研究成果造福于人类。第二:继对神经变性疾病,例如阿尔茨海默病、帕金森氏病、运动神经元病和脊髓小脑变性疾病进行分子生物学分析,并发现上述疾病的某些变异基因之后,目前我们正利用转基因动物模型来进行基因和干细胞的实验性治疗和研究。第三:针对脑血管疾病、痴呆、神经变性疾病和糖尿病的临床神经生理学的研究,我们更多的应用MRI、CT、螺旋CT、超声波、肌电图和脑磁图等临床手段。
上述神经科疾患的发病率,不论是发达国家还是发展中的国家都呈日益增加的趋势。我们坚信我们的基础和临床研究,必将会给这些领域带来积极的影响。我们随时期待,关注脑神经科疾患的朋友与我们联系。一直以来,来自世界各地的研究人员在我们科室从事研究和交流。我由衷的希望我们的科室,能够成为世界各地有志于脑神经科疾患研究的年轻朋友进行研究和交流的平台。

阿部 康二 教授 MD, PhD

<阿部 康二 教授 简历>
1981年 毕业于日本东北大学医学部(MD)
1987年 毕业于日本东北大学医学部(PhD)
1988 - 1990年 美国哈佛大学医学部客座研究员
1990年 日本东北大学医学部神经内科 助教
1995年 日本东北大学医学部神经内科 讲师
1996年 日本东北大学医学部神经内科 副教授
1998年 日本冈山大学医学部神经内科 教授
2002-2003年 日本冈山大学医学部附属医院 副院长
2007年 第23届国际脑循环代谢会议 主席
2009-2011年 国际脑循环代谢协会 主席




Asidan的发现


脊髓小脑变性病作为神经难治病被广为人知。此类病中,我们发现一种与筋萎缩性脊髓侧索硬化症(ALS)相似的新型病症—脊髓小脑变性病36型(别名:Asidan)。我们通过和京都大学(小泉昭夫)的共同研究,已将该病致病基因解析。第20号染色体上的NOP56基因内,6个碱基1500-2500次的异常扩增已被探明。该成果于2011年被刊登在American Journal of Human Genetics杂志上(论文1)。
另外,通过对该病的8个家族的临床图像总结,比较分析得出,该病是一种表现在舌头及四肢运动神经元上的纯粹的小脑性运动失调症,该报告于2012年发表在Neurology上(论文2)。

除此以外,认知机能低下,听觉低下,吞咽困难等症状的发生也被相继报道出来(论文3-5)。

还有,ALS模型鼠脊髓中NOP56蛋白的逐渐减少(论文6)和Asidan病人神经元中存在的巨大RNA foci 也在我们的研究中被报道出来(论文7) 。
今后,我们计划把从患者身上得到的iPS细胞分化成神经细胞后,在细胞水平方面再现该病,对其病态机制进行解析研究。

Figure 1
Figure 2
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Figure 5
Figure 6
Figure 7
Figure 8
论文 1 Manabe Y, Shiro Y, Takahashi K, Kashihara K, Abe K (2000) A case of spinocerebellar ataxia accompanied by severe involvement of the motor neuron system. Neuro Res 22:567-70.
 论文 2  Ohta Y, Hayashi T, Nagai M, Okamoto M, Nagotani S, Nagano I, Ohmori N, Takehisa Y, Murakami T, Shoji M, Kamiya T, Abe K (2007) Two cases of spinocerebellar ataxia accompanied by involvement of the skeletal motor neuron system and bulbar palsy. Intern Med 46:751-5.
 论文 3  Kobayashi H, Abe K, Matsuura T, Ikeda Y, Hitomi T, Akechi Y, Habu T, Liu W, Okuda H, Koizumi A (2011) Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement. Am J Hum Genet 89: 121-30.
论文 4 Ikeda Y, Ohta Y, Kobayashi H, Okamoto M, Takamatsu K, Ota T, Manabe Y, Okamoto K, Koizumi A, Abe K (2012) Clinical features of SCA36: a novel spinocerebellar ataxia with motor neuron involvement (Asidan). Neurology 79: 333-41.
论文 5 Abe K, Ikeda Y, Kurata T, Ohta Y, Manabe Y, Okamoto M, Takamatsu K, Ohta T, Takao Y, Shiro Y, Shoji M, Kamiya T, Kobayashi H, Koizumi A. (2012) Cognitive and affective impairments of a novel SCA/MND crossroad mutation Asidan. Eur J Neurol 19: 1070-1078.
论文 6 Ikeda Y, Ohta Y, Kurata T, Shiro Y, Takao Y, Abe K. (2012) Acoustic impairment is a distinguishable clinical feature of Asidan/SCA36. J Neurol Sci 324: 109-112.
论文 7 Morimoto N, Yamashita T, Sato K, Kurata T, Ikeda Y, Kusuhara T, Murata N, Abe K. (2012) Assessment of swallowing in motor neuron disease and Asidan/SCA36 patients with new methods. J Neurol Sci 324: 149-155.
论文 8 Miyazaki K, Yamashita T, Morimoto N, Sato K, Mimoto T, Kurata T, Ikeda Y, Abe K. (2013) Early and selective reduction of NOP56 (Asidan) and RNA processing proteins in the motor neuron of ALS model mice. Neurol Res 35: 744-754.
论文 9 Liu W, Ikeda Y, Hishikawa N, Yamashita T, Deguchi K, Abe K. (2014) Characteristic RNA foci of the abnormal hexanucleotide GGCCUG repeat expansion in spinocerebellar ataxia type 36 (Asidan). Eur J Neurol. 21: 1377-1386.
论文 10 Ohta Y, Yamashita T, Hishikawa N, Sato K, Matsuzono K, Tsunoda K, Hatanaka N, Takemoto M, Takemi T, Takamatsu K, Abe K. (2017) Potensional multisystem degeneratoin in Asidan patients. J Neurol Sci. 373: 2016-2222.
论文 11 Matsuzono K, Imamura K, Murakami N, Tsukita K, Yamamoto T, Izumi Y, Kaji R, Ohta Y, Yamashita T, Abe K, Inoue H. (2017) Antisense Oligonucleotides Reeduce RNA Foci in Spinocerebellar Ataxia 36 Patient iPSCs. Mol Ther Nucleic Acids 15:211-219Potensional multisystem degeneratoin in Asidan patients. J Neurol Sci. 373: 211-212.




Link To International Asidan Symposium 2016 page

In English 简体中文

国际Asidan (脊髓小脑变性病亚型)专题讨论会 概要



时间:2016年7月8-9日(星期五~星期六)
地点:欧风亭酒店
广岛县福山市鞆街鞆136
(电话:084-982-1123)
http://www.ofutei.com/index.html

交通:日本铁路(JR )的福山站坐客车15分可预约接送

(*)欢迎SCD和ALS以及认知症相关内容的发表。

学会时间安排






阿部式 BPSD评分(Abe's BPSD Score = ABS)


为了适应现代日本,开发了新的阿部式BPSD评分(Abe's BPSD Score=ABS)(点击可以打开文件)。
因为本评分是患者免费使用,非常欢迎在日常诊疗时自由使用。
如有希望本评分以册子形式发送的情况,请和冈山大学神经内科联系。

如在学会发表以及论文发表的时候使用本评分,欢迎引用以下的论文。


Abe K, Kurata T, Deguchi K, Kono S, Sato K, Omote Y, Matsuzono K, Yamashita T, Ikeda Y et al.A new simple score (ABS) for screening behavioral and psychological symptoms of dementia. 21th European Congress of Psychiatry (EPA2013) in Nice, France

Abe K, Yamashita T, Hishikawa N, Ohta Y, Deguchi K, Sato K, Matsuzono K, Nakano Y, Ikeda Y, Wakutani Y, Takao Y. A new simple score (ABS) for assessing behavioral and psychological symptoms of dementia. J Neurol Sci. (2015) 350:14-17.

(〒700-8558冈山市北区鹿田街2-5-1 电话086-235-7365,传真086-235-7368)


神経内科学全般


阿部式BPSD评分(ABS)


目前老年痴呆症患者的护理者经常使用神经精神量表(Neuropsychiatric Inventory,NPI)用来评价患者的精神症状。
新开发的阿倍式BPSD评分(ABS)(图1)与NPI评分的关联性很高(图2),高龄化MMSE评分下降,与之相关联BPSD评分增加(BPSD恶化)(图相3),因此可以信任BPSD评分。
此外,与NPI评分相比,BPSD评分所用时间较短(图4),并且保持可靠性(图5)。.
基于以上,阿部式BPSD评分(ABS),比较适合繁忙的日常诊疗工作,因此请在平时的诊疗中使用。





Ice Bucket Challenge by Koji Abe






Amyotrophic lateral sclerosis (ALS) information


The 3rd phase clinical trial of MCI-186 for ALS patients


The 3rd phase (2nd round) clinical trial of MCI-186 (Edaravone (Radicut)) for ALS patients, which had been started from July 2006 in Japan (Okayama University was the center hospital of this clinical trial), finished recently.
  The results of 1st round of this clinical trial showed the efficacy of Edaravone for ALS patints. Professor Abe reported the results as a first author of the below paper.
  The paper presented the safety of Edaravone and the efficacy in the pinch strength of ALS patients.

1. Abe K, Itoyama Y, Sobue G, Tsuji S, Aoki M, Doyu M, Hamada C, Kondo K, Yoneoka T, Akimoto M, Yoshino H. Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients. Amyotroph Lateral Scler Frontotemporal Degener. 2014; 6:1-8.

2. Abe K, Aoki M, Tsuji S, Itoyama Y, Sobue G, Togo M, Hamada C, Tanaka M, Akimoto M, Nakamura K, Takahashi F, Kondo K, Yoshino H, Sasaki H, Yabe I, Doi S, Warita H, Imai T, Ito H, Fukuchi M, Osumi E, Wada M, Nakano I, Morita M, Ogata K, Maruki Y, Ito K, Kano O, Yamazaki M, Takahashi Y, Ishiura H, Ogino M, Koike R, Ishida C, Uchiyama T, Mizoguchi K, Obi T, Watanabe H, Atsuta N, Aiba I, Taniguchi A, Sawada H, Hazama T, Fujimura H, Kusaka H, Kunieda T, Kikuchi H, Matsuo H, Ueyama H, Uekawa K, Tanaka M, Akimoto M, Ueda M, Murakami A, Sumii R, Kudou T, Nakamura K, Morimoto K, Yoneoka T, Hirai M, Sasaki K, Terai H, Natori T, Matsui H, Kotani K, Yoshida K, Iwasaki T, Takahashi F, Kondo K, Yoshino H. Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2017; 16: 505-512



Overview of the Department of Neurology, Okayama University


Toru Yamashita, Senior member of staff


The young and attractive Department of Neurology, Okayama University, is in its 27th year of operation, and 21th year since Prof. Koji Abe assumed the position of director. There are 7 teaching staff members working under Prof. Abe, as well as 11 medical staff and 3 postgraduates and researchers working enthusiastically on medical care, education, and research. Including fellow students, young doctors undergoing training in internal medicine and neurology off campus, as well as doctors newly appointed as department and section heads at affiliated hospitals off campus, there is a total of 80 individuals involved in the laboratory. Our energy has long since been focused on student education and medical training, and as of 2004, postgraduate clinical training of doctors became compulsory. To achieve our goal of having ‘all doctors acquire a wide range of basic clinical skills,’ which is now required, we established an improved training program with the most appropriate training in the department of neurology that enables the patient to be thoroughly examined. The laboratory members work happily together every day to foster highly skilled neurologists and physicians.
Patients from the Chugoku, Shikoku, Kansai, Kyushu, and the more distantly located Kanto and Tokai regions are referred to the Department of Neurology at Okayama University hospital as general new outpatients of Prof. Abe. New patients are mainly taken care of by Prof. Abe and his staffs. Returning patients are received through the special outpatient system with amyotrophic lateral scleosis patients appointed to Dr. Yamashita, neurodegenrative diseases to Dr. Sato, dementia cases to Dr. Ohta and Dr. Nomura, Parkinson's disaease cases to Dr. Takemoto and Dr. Tadokoro, neuroimmune diseases to Dr. Kitayama and Dr. Matsumoto, and stroke to Dr. Tsunoda and Dr. Hishikawa, who provide advanced medical care to the outpatients. At in-patients ward, many attending physicians play an active role under Dr. Sato, the Department of Neurology ward’s medical director. The number of outpatients and inpatients per year in the Department of Neurology is rapidly increasing, and we have felt an increasing social demand for the Department of Neurology. The number of patients referred from affiliated hospitals within and outside of Okayama prefecture has also increased and cooperation between the departments of internal medicine, neurology, and brain surgery of regional medical institutions has grown increasingly closer.
Research activities are being actively expanded in addition to medical care and educational initiatives. The research system is divided into 3 groups of diseases with the most patients and highest social demand, namely stroke, neurodegenerative disease, and dementia, for which laboratory members happily engage in research every day. Many our laboratory members have the opportunity for studying abroad, including Harvard and Stanford University in the USA, Toronto University in Canada, and CR CHU in Quebec for international research activities and there is a great deal of collaborative research underway. In 2007, for the first time in 14 years, Japan (Osaka) held the 23rd International Symposium on Cerebral Blood Flow and Metabolism (world’s largest brain science-related conference) with Prof. Abe from our laboratory as the chairperson. The event was a great success with the most participants that have ever attended this symposium. Further, in 2009, Prof. Abe was appointed president of the International Society of Cerebral Blood Flow and Metabolism, and in Fall 2010, the first World Forum on Cerebral Blood Flow and Metabolism was hosted in Kyoto. In 2011, the 25th International Symposium on Cerebral Blood Flow and Metabolism was held in Barcelona, Spain. The 26th Japanese Symposium on Cerebral Blood Flow and Metabolism is scheduled for November 2014. These events have enabled the Department of Neurology at Okayama University to contribute to developments in neuroscience, and thus gain international recognition as a laboratory. In the 21 years that Prof. Abe has been in his position, 5 new professors in neurology at national universities have emerged, namely Dr. Mikio Shoji at Hirosaki University in 2006, and Dr. Tohru Matsuura at Jichi Medical University, Dr. Yoshio Ikeda at Gunma University, Dr. Etsuro Matsubara at Oita University in 2013, and Dr. Takeshi Hayashi at Saitama medical university International medical Center in 2015. Therefore, our laboratory is a place where medical staff members work together not only for Japan, but for the whole world.




Our Recent Scientific Papers


引起末梢神经病变的朊蛋白病

朊蛋白病, 病理表现多种多样, 一般临床表现为急性多发性中枢神经系统病变, 常与老年痴呆, 小脑共济失调为主的神经病或神经精神疾病伴随发生。
我们已在临床上发现了朊蛋白病新的表现型,其特征为周围自主神经及感觉神经病变。 此病是由于朊蛋白的第178号密码子的CT两碱基缺失导致,此病患者末梢神经病理活检可见有朊蛋白沉着, 此次研究成果已发表在2013年的European Journal of Neurology上(论文1)。
最近,英国的研究团队在2013年的新英格兰杂志(NEJM)上也报导了临床症状(腹泻及自主神经病变症状)非常相似,且由于朊蛋白的第163号密码子被切断所致的朊蛋白病。(参考论文1)。对于相关类似的研究,我们的研究团队非常感兴趣。
论文 1 Matsuzono K, Ikeda Y, Liu W, Kurata T, Deguchi S, Deguchi K, Abe K (2013) A novel familial prion disease causing pan-autonomic-sensory neuropathy and cognitive impairment. Eur J Neurol 20:e67-9.
参考论文 1 Mead S, Gandhi S, Beck J, Caine D, Gallujipali D, Carswell C, Hyare H, Joiner S, Ayling H, Lashley T, Linehan JM, Al-Doujaily H, Sharps B, Revesz T, Sandberg MK, Reilly MM, Koltzenburg M, Forbes A, Rudge P, Brandner S, Warren JD, Wadsworth JD, Wood NW, Holton JL, Collinge J (2013) A novel prion disease associated with diarrhea and autonomic neuropathy. N Engl J Med 369:1904-14.

脑梗塞 用光影像特别鉴定

脑梗塞通常用MRI或者CT等手段进行诊断,但对于治疗效果的判定以及早期诊断来说,新的画像诊断技术的开发一直被人们所探求。
本研究室,在LC3-GFP转基因小鼠脑梗塞模型的基础上,将头皮出去后,通过特殊高敏度照相机观察小鼠大脑。我们发现,在缺血状态下的小鼠脑里面,自噬(autophagy)作用被强烈的诱导,并且发光。该成果在2010年被刊登在Autophagy杂志上(论文1)。
今后,我们期待新的临床应用发光药剂及检查机器,以便能有更加便利且高感度的脑梗塞病变检出方法的出现。
论文 1 Tian F, Deguchi K, Yamashita T, Ohta Y, Morimoto N, Shang J, Zhang X, Liu N, Ikeda Y, Matsuura T, Abe K (2010) In vivo imaging of autophagy in a mouse stroke model. Autophagy 6:1107-14.





神经内科研究者的心得体会


脑神经内科助教 商敬伟

冈山在日本被称为晴天之国,冈山大学医学部在日本医学排名在前5位,脑神经内科教授阿部康二老师在日本以及国际神经医学界享誉盛名,是脑保护剂Edaravone的发明者,同时是脊髓小脑变性病Asidan的命名者,也是首位担任国际脑血管代谢学会会长的亚洲人,在阿部教授的指导下冈大神经内科每年发表30篇左右的SCI论文。
本人于2011年在冈山大学脑神经内科完成博士学位,读博期间以第一作者发表了3篇SCI论文。毕业后回国做了3年的神经内科医生,期间申请并获得了一项国自然科研基金。为了进一步研究脑卒中及神经变性疾病的发病机制及治疗方法,于2015年再次来到冈大脑神经内科学习,因阿部教授对本人工作的认可,于2016年成为神经内科首位外国人助教,担任科研及教学工作,现已发表30余篇SCI论文,并且于2017年获得了两年300万日元的研究经费,多次在国际学会上发表,取得的结果得到了专家们的认可。
本科室欢迎并且包容世界各国留学生,这使我们的研究气氛非常积极及融洽,在这里可以尽情工作,学习,研究。


大学院博士课程 刘夏

我是来自中国黑龙江省哈尔滨市的留学生。在哈尔滨医科大学完成硕士课程后,因为对科研的浓厚兴趣,于2016年4月开始在冈山大学的神经内科攻读博士学位。
两年的留学生活让我学到了很多。研究室的老师和同学都很亲切,在科研和生活上都给予了我很大的帮助。而且每年有很多机会参加国内及国际的学会,对于开拓视野和研究交流都有很大的好处。
在日本的留学生活不但让我学到了知识,更让我锻炼了独立生活的能力,在感受异国文化的同时,也学会如何适应新的环境,如何与人沟通,是一次非常有意义的体验。


大学院博士課程 施晓雯

冈山大学坐落于日本冈山县冈山市,在这里,开始了我为期四年紧张忙碌而又充实的留学生活。
初见阿部教授,并没有我想象中的那般严肃刻板,而是和蔼可亲,平易近人。科室氛围和谐融洽,实验室设备齐全,环境整洁舒适,在浓厚的学习氛围下,很快我便融入到这个大家庭。从阿部教授到医局长到助教,都在为我们每一步的实验把关,不断修改,不断完善。从课题选题到设计,从实验进行到最终投稿,踏踏实实的做好每一步,掌握实验室常见操作技术,培养良好的科研习惯。在忙碌的科研生活之余还有机会参加各种学术会议、讲座,有助于我们拓宽知识面,了解自身科研领域的发展方向,从科研小白逐渐成长起来。
在这里经过了一年多的学习生活使我切身感受到了日本人在日常学习生活中所表现出对于细节的执着以及这个国家规则秩序至上的社会大环境,在感受不同文化拓宽视野的同时,更重要的是培养了我认真严谨细致的科研态度,以及提高了自身的学术水平和科研能力。




Contact Us


Address 2-5-1, Shikatacho, Kita-ku, Okayama-shi, Okayama, 700-8558, Japan
TEL +81-86-235-7365