Mechanomedicine

NARUSE, Keiji

/ Graduate School of Medicine, Dentistry and Pharmaceutical Sciences / Professor
/ knaruse[at]md.okayama-u.ac.jp

Mechanical stress underlies most aspects of cell and organismal biology. Mechanomedicine is a field of biology that seeks to understand molecular, cellular, tissue, organ, and individual responses to mechanical stimuli and aims to apply the gained knowledge to improve health. Combining biology and engineering, we explore research areas including mechanosensitive ion channels, heart failure, and regenerative medicine.Our interests: Mechanobiology, Regenerative medicine, Heart failure, Arrhythmia, Cellular and molecular biology, Electrophysiology, Computer simulation

Reference:Katanosaka Y, Iwasaki K,Ujihara Y,Takatsu S,Nishitsuji K, Kanagawa M, Sudo A, Toda T, Katanosaka K,Mohri S,Naruse K. TRPV2 is critical for the maintenance of cardiac structure and function in mice.?Nat Commun?5: 3932 (2014)

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Stretch system for mechanobiology research Left: a flexible silicone chamber used for applying stretch stimulus to adherent cells. The transparent floor enables live imaging of cultured cells. Right: a computer controlled stretch device. Stretch ratio, speed, and intervals can be precisely controlled by computer.