World's First Cancer Stem Cells from iPS Cells

Masaharu Seno

/ Graduate School of Natural Science and Technology / Professor/ mseno[at]okayama-u.ac.jp

We successfully developed cancer stem cells (CSCs) from induced pluripotent stem cells (iPSCs) for the first time in the world. The CSCs produced from iPSCs exhibited differentiation and sphere formation as well as malignant tumorigenicity in vivo. Both differentiated and undifferentiated states of the CSCs are demonstrated to be necessary for the maintenance of the cancer cells themselves. Further, various differentiated phenotypes from the CSCs are implied to be present. Through the CSC models, the mechanisms governing the development of cancer should be understood and then a major advance for the treatment of cancer would be achieved.

References:Chen L, Seno M. et al. Mouse induced pluripotent stem cell microenvironment generates epithelial-mesenchymal transition in mouse Lewis lung cancer cells. Am J Cancer Res. 2014 Jan 15;4(1):80-88.
Yan T, Seno M. et al. Characterization of cancer stem-like cells derived from mouse induced pluripotent stem cells transformed by tumor-derived extracellular vesicles. J Cancer. 2014 Jul 5;5(7):572-584. Matsuda S, Seno M, et al. Cancer stem cells maintain a hierarchy of differentiation by creating their niche. Int J Cancer. 2013.
Chen L, Seno M, et al. A model of cancer stem cells derived from mouse induced pluripotent stem cells. PLoS One. 2012;7(4):e33544

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The microenvironment niche plays a significant role in the proper differentiation of stem cells, while the cancerous niche drives stem cells into malignant cells.