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Reduced form of co-enzyme Q10 has anti-aging effects on periodontal tissues

June 17, 2013

Researchers from the Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences have found that applying the reduced form of co-enzyme Q10 (rCoQ10) on the gums of rats suppresses age-related inflammatory reactions of the gums.

The findings were published in the Journal of Dental Research on May 21, 2013.
http://jdr.sagepub.com/content/early/2013/05/20/0022034513490959.long

Oxidative stress is associated with age-related reactions. The study suggested that applying rCoQ10 on the gums suppresses age-related inflammatory reactions through anti-oxidative effects of rCoQ10. Further study could lead to anti-aging applications in the field of dentistry.

Professor Morita and his colleagues in Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences examined the effects of topically applied rCoQ10 on periodontal inflammatory reactions in a rat aging model. 12 rats (4-months-old) were divided into 2 groups, one group received topically applied ointment with 1% rCoQ10 on the gingival surface and the other group received the ointment without rCoQ10. This was done for 2 months. The results showed that rCoQ10 decreased oxidative DNA damage and also resulted in tartrate-resistant acid-phosphatase-positive osteoclasts in the periodontal tissue at 6 months of age as compared with the control.

The results suggest that rCoQ10 suppresses age-related inflammatory reactions and osteoclast differentiation by inhibiting oxidative stress. Applying rCoQ10 to oral care products could contribute maintenance and enhancement of oral health.

This study was funded by the Japan Society for the Promotion of Science (JSPS) [ #24593153 ].



Contact Information:
Mototaka Senda, Ph.D.
Intellectual Property Office, Organization for Research Promotion and Collaboration
US Representative, Fremont, California USA
TEL: 1-510-797-0907
Email: takasenda@okayama-u.ac.jp

Manabu Morita,
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

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