Summary: Todayfs general anesthetics are the most potent depressors of nervous system which affect regulation of breathing and heart function. They have a fairly narrow safety margin between the therapeutic dose and a dose that is toxic, even lethal.
Anesthetics affect the central nervous system, and produce a state of reversible coma or anesthesia. The depth of anesthesia (DoA) depends on the equilibration of drug concentrations in plasma with drug concentrations at the effect site, the measured drug effect, and the influence of noxious stimuli. In clinical monitoring practice, neither the main effect site nor the anestheticsf concentrations at the effect sites are known. Modern DoA monitor systems use frontal electroencephalogram (EEG) signal to derive an index value, which decreases monotonically with increasing anesthetic drug levels. This study is to investigate the accurate relationship between DoA and frontal EEG signals, and develops a high reliable and accurate indicator for DoA.
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