Publications (April1st, 1994 〜 December 31st, 2000)

 

1.        Zhu, J., Pan, H.O., Suzuki, F. andTakigawa, M.: Proto-oncogeneexpression in a human chondrosarcoma cell line:HCS-2/8. Jpn. J. Cancer Res.,85, 364-371, 1994.

2.        Farres, J., Wang, X., Takahashi K., CunninghamS.J., Wang T.T andWeiner H.: Effects of changing glutamate 487 to lysine in ratand human livermitochondrial aldehyde dehydrogenase. J. Biol. Chem., 269,13854-13860, 1994.

3.        Iwamoto, M., Jikko, A., Murakami, H.,Shimazu, A., Nakashima, K.,Iwamoto, M., Takigawa, M., Baba, H., Suzuki, F. andKato, Y.: Changes inparathyroid hormone receptors during chondrocytecytodifferentiation. J. Biol.Chem., 269, 17245-17251, 1994.

4.        Tuckwell, D.S., Ayad, S., Grant,M.E., Takigawa, M. and HumphriesM.J.:Conformation dependence of integrin-type・ collagen binding. J. Cell Science,107,993-1005, 1994.

5.        Kishino, A., Nakayama, C., Nakanishi,T., Fukushima, N., Irie, T.andNoguchi, H.: Monoclonal antibodies raised against rat hippocampalhomogenate andthe characterization of antigens. Hybridoma, 13, 311-316, 1994.

6.        Nakanishi, T., Takahashi, K., Aoki,C., Nishikawa, K., Hattori, T.and Taniguchi, S.: Expression of nerve growthfactor family neurotrophins in amouse osteoblastic cell line. Biochem. Biophys.Res. Commun., 198, 891-897,1994.

7.        Nakanishi, T., Ohyama, K., Aoki, C.,Kudo, A., Hattori, T.,Takahashi, K., Taniguchi, S. and Takigawa, M.: Expressionof trkC in a mouseosteoblastic cell line and its response to neurotrophin-3.Biochem. Biophys.Res. Commun., 203, 1268-1274, 1994.

8.        Takahashi, K., Hattori, T., Nakanishi,T., Nohno, T., Fujita, N.,Ishihama, A. and Taniguchi, S.: Repression of invitro transcription of theEscherichia coli fnr and narX genes by FNR protein.FEBS Lett., 340, 59-64,1994.

9.        Nishikawa, K., Nakanishi, T., Aoki,C., Hattori, T., Takahashi, K.and Taniguchi, S.: Differntial Expression ofHomeobox-containing Genes Msx-1and Msx-2 and Homeoprotein Msx-2 Expressionduring Chick Craniofacial Development.Biochem. Mol. Biol.International, 32,763-771, 1994.

10.    Ohuchi, H., Koyama, E., Myokai, F., Nohno, T., Shiraga, F.,Matsuo,T., Matsuo, N., Taniguchi, S. and Noji, S.: Expression patterns oftwofibroblast growth factor receptor genes during early chickeyedevelopment.  Experimental EyeResearch,58, 649-658, 1994.

11.    Takashiba, S., Noji, S., Nishimura, F., Oyama, H., Kurihara,H.,Nomura, Y., Taniguchi, S. and Murayama, Y.: Unique intronic variationsofHLA-DQβ genein early-onset periodontitis. J. Periodontol.., 65, 379-386,1994.

12.    Matsuura, H., Myokai, F., Arata, J., Noji, S. and Taniguchi,S.:Expression of type・transforming growth factor-β receptor mRNA in human skin, as revealed by in situhybridization.J. Dermatol. Sci., 8, 25-32, 1994.

13.    Hisa, T., Hamada, T., Hirachi, Y., Yoshioka, M., Takigawa, M.andShigenaga, Y.: Senile lip licking. Dermatology, 191, 339-340, 1995.

14.    Hisa, T., Mochida, K., Taniguchi, S., Goto, Y., Hamada, T.,Yoshioka,M., Shigenaga, Y. and Takigawa, M.: Contact dermatitis fromcarboxyvinylpolymer. Contact Dermatitis, 33, 271, 1995.

15.    Hisa, T., Taniguchi, S., Kobayashi, H., Shigenaga, Y., Nomura, S.andTakigawa, M.: Apoptosis in normal skin. Acta Derm. Venereol., 75, 412-413,1995.

16.    Ohba, Y., Goto, Y., Kimura, Y., Suzuki, F., Hisa, T., Takahashi,K.and Takigawa, M.: Purification of an angiogenesis inhibitor from culturemediumconditioned by a human chondrosarcoma-derived chondrocytic cell line,HCS-2/8.Biochim. Biophys. Acta, 1245, 1-8, 1995.

17.    Nakanishi, T., Ishii, K., Katayama, M., Araki, W., Iwata, E.andOgawa, N.: Characterization of neurotrophic factors produced byimmortalizedmouse brain glial cells (VR-2g). Biochem. Mol. Biol. Int., 36,991-999, 1995.

18.    Kinoshita, A., Tamura, T., Aoki, C., Nakanishi, T., Sobue,S.,Suzuki, F., Takahashi, K. and Takigawa, M.: Demonstration of endothelin(ET)receptors on cultured rabbit chondrocytes and stimulation of DNA synthesisandcalcium influx by ET-1 via its receptors. Cell Biol. Int., 19, 647-654,1995.

19.    Asanuma, M., Kondo, Y., Nishibayashi, S., Iwata, E., Nakanishi,T.and Ogawa, N.: Age-related changes in composition of transcription factor,AP-1complex in the rat brain. Neurosci. Lett., 201, 127-130, 1995.

20.    Hisa, T., Ishii, M., Hirachi, Y., Onda, H., Mohri, I.and Takigawa,M.: Is atopic dermatitis related to the month of birth?Zeitschrift Dermatol.,181, 208-210, 1995.

21.    Matsuhashi, S., Noji, S., Koyama, E., Myokai, F., Ohuchi,H,Taniguchi, S. and Hori, K.: A new gene, nel,encoding a Mr.93 K protein withEGF-likerepeats is strongly expressed in neural tissues of early stage chickembryos.,Develop. Dynamics, 203, 212-222, 1995.

22.    Ishizeki, K., Takigawa, M., Nawa, T., Harada, Y. and Suzuki,F.:Meckel's cartilage chondrocytes in organ culture synthesize bone-typeproteinsaccompanying osteocytic phenotype expression. Anat. Embryol., 193, 61-71,1996.

23.    Ishizeki, K., Takigawa, M., Nawa, T. and Suzuki, F.: MouseMeckel'scartilage chondrocytes evoke bone-like matrix and further transformintoosteocyte-like cells in culture. Anat. Res., 245, 25-35, 1996.

24.    Hattori, T., Takahashi, K., Nakanishi, T., Ohta, H., Fukui,K.,Taniguchi, S. and Takigawa, M.: Novel FNR homologues identified infourrepresentative oral facultative anaerobes: Capnocytophaga ochracea,Capnocytophagasputigena, Haemophilus aphrophilus, and Actinobacillusactino-mycetemcomitans.FEMS Microbiol. Lett., 137, 213-220, 1996.

25.    Tsuji, M., Funahashi, S., Takigawa, M., Seiki, M., Fujii, K.andYoshida, T.: Expression of c-fos gene inhibits proteoglycan synthesisintransfected chondrocyte. FEBS Lett., 381, 222-226, 1996.

26.    Iwata, E., Nakanishi, T., Ogawa, N., Ohyama, K., Murakami, T. andTakigawa,M.: Neurotrophin-3 increases the DNA-binding activities of severaltranscriptionfactors in a mouse osteoblastic cell line. Biochim. Biophys.Acta, 1311, 85-92,1996.

27.    Sakawa, A., Yutani, Y., Inui, K., Shimizu,A., Yamano, Y.,Kinoshita, A., Suzuki, F., Hattori, T. and Takigawa, M: Specificserumantibodies against membranous proteins of a human immortal chondrocyticcellline (HCS-2/8) in rheumatoid arthritis and their relation to thenaturalhistory of the disease. J. Bone Miner. Metab., 14, 146-152, 1996.

28.    Nakanishi, T., Ishii, K., Fukushima,N., Asanuma, M., Iwta, E. andOgawa, N.: Expression of mRNA encodingneurotrophic factors and its regulationin a hybrid neuronal cell line. Biochem.Mol. Biol. Int., 38, 763-772, 1996.

29.    Tamura, T., Nakanishi, T., Kimura, Y., Hattori, T., Sasaki,K.,Norimatsu, H., Takahashi, K. and Takigawa, M.: Interleukin-1 induces Matrixdegradationand release of basic fibroblast growth factor in clutured rabbitarticularchondrocytes via nitric oxide production: A possible mechanism ofpathologicalneovascularization in arthritis. Endocrinology, 137, 3729-3737,1996.

30.    Hisa, T., Taniguchi, S., Tsuruta, D., Hirachi, Y., Ishizuka, S.andTakigawa, M.: Vitamin D inhibits endothelial cell migration. Arch.Dermatol.Res., 288, 262-263, 1996.

31.    Hisa, T., Taniguchi, S., Kakudo, K., Ichihashi, M., Takashima,T.,Kato, Y., Hayakawa, R. and Takigawa, M.: Establishment of an in vitrocellderived from human angiosarcoma. Bull Cancer, 83, 589-591, 1996.

32.    Takahashi, K., Kubo, T., Kobayashi, K., Imanishi, J., Takigawa,M.,Arai, Y. and Hirasawa, Y.: Hydrostatic pressure influences mRNA expressionoftransforming growth factor-β1 and heat shock protein 70 in chondrocyte-ike cell line.J.Orthopaedic Res., 15, 150-158, 1997.

33.    Nakagawa, K., Sakiyama, H., Fukusawa, T., Matsumoto, M.,Takigawa,M., Toyoguchi, T. and Moriya, H.: Coordinate change between complementC1sproduction and chondrocyte differentiation in vitro. Cell and Tissue Res.,289,299-305, 1997.

34.    Nakanishi, T., Kimura, Y., Tamura, T., Ichikawa, H., Yamaai, Y.,Sugimoto,T., and　Takigawa, M.: Cloning of a mRNA preferentially expressedinchondrocytes in differential display PCR from a human chondrocytic celllinethat is identical with connective tissue growth factor (CTGF) mRNA.Biochem.Biophys. Res. Commun., 234, 206-210, 1997.

35.    Arai, Y., Kubo, T., Kobayashi, K., Takeshita, K., Takahashi,K.,Ikeda, T., manishi, J., Takigawa, M. and Hirasawa, Y.:Adenovirusvector-mediated gene transduction to chondrocytes: In vitroevaluation oftherapeutic efficacy of transforming growth factor-b1 and heatshock protein 70gene transduction. J. Rheumatol., 24, 1787-1795, 1997.

36.    Takigawa, M., Okawa, T., Pan H.-O., Aoki, C., Takahashi, K.,ZueJ.-D. and Kinoshita, A.: Insulin-like growth factors ・and II areautocrinefactors in stimulating proteoglycan synthesis, a marker ofdifferentiatedchondrocytes, acting through their respective receptors on aclonal humanchondrosarcoma-derived chondrocyte cell line, HCS-2/8.Endocrinology, 138,4390-4400, 1997.

37.    Davis, D., Tuckwell,D.S., Calderwood,D.A., Weston,S.A.,Takigawa, M.and  Humphries, M.J. :Molecularcharacterization of integrin-procollagen C-propeptide interactions.Eur. J.Biochem., 246, 274-282, 1997.

38.    Ishida, O., Tanaka, Y., Morimoto, I.,Takigawa, M. and Eto, S.:Chondrocytes are regulated by cellular adhesion thoughCD44 and hyaluronic acidpathway., J. Bone Miner. Res., 12, 1657-1663, 1997.

39.    Sasaki, K., Hattori, T., Fujisawa,T., Takahashi, K., Inoue, H. andTakigawa, M.: Nitric oxide mediatesinterleukin-1-induced gene expression ofmatrix metalloproteinases and basicfibroblast growth factor in cultured rabbitarticular chondrocytes. J. Biochem.,123, 431-439, 1998.

40.    Hattori, T., Fujisawa,T., Sasaki, K., Yutani, Y., Nakanishi, T.,Takahashi, K. and Takigawa, M.:Isolationand characterization of a rheumatoidarthritis-specific antigen (RA-A47) from ahuman chondrocytic cell line(HCS-2/8). Biochem. Biophys. Res. Commun. 245,679-683, 1998.

41.    Hisa, T., Kimura, Y., Takada, K., Suzuki, F. and Takigawa,M.:Shikonin, an igredient of lithospermum erythrorhizon, inhibits angiogenesisinvivo and in vitro. Anticancer Res., 18, 783-790, 1998.

42.    Funayama, T., Nakanishi, T., Takahashi, K., Taniguchi, S.,Takigawa,M. and Matsumura, T.: Overexpression of c-erbB-3 in various stages of humansquamouscell carcinoma. Oncology, 55, 161-167, 1998.

43.    Shimo, T., Nakanishi, T., Kimura, Y., Nishida, T., Ishizeki,K.,Matsumura, T. and Takigawa, M.: Inhibition of endogenous expressionofconnective tissue growth factor by its antisense oligonucleotide andantisenseRNA suppresses proliferation and migration of vascular　endothelial cells.J.Biochem., 124, 130-140, 1998.

44.    Aoki, C., Nakanishi, T., Sogawa, N., Ishii, K., Ogawa, N.,Takigawa,M. and Furuta, H.: Stimulatory effects of 4-methylcatechol, dopamineandlevodopa on the expression of metallothionein-・(GIF) mRNA in immortalizedmouse brain glialcells (VR-2g). Brain Res., 792, 335-339, 1998.

45.    Fujimoto, W., Nakanishi, G., Hirakawa, S., Nakanishi, T., Shimo,T.,Takigawa, M. and Arata, J.: Pachyonychia congenita type 2: Keratin 17mutationin a Japanese case. J. Am. Acad. Dermatol., 38, 1007-1009, 1998.

46.    Nishida, T., Nakanishi, T., Shimo, T., Asano, M., Hattori,T.,Tamatani, T., Tezuka, K. and Takigawa, M.: Demonstration of receptorsspecificfor connective tissue growth factor on a human chondrocytic cellline(HCS-2/8).  Biochem. Biophys. Res.Commun.,247, 905-909, 1998.

47.    Takahashi, K., Kubo, T., Arai, Y., Kitajima, I.,Takigawa, M.,Imanishi, J. and Hirasawa, Y.: Hydrostatic pressure inducesexpression ofinterleukin 6 and tumour necrosis factor α mRNAs in achondrocyte-like cell line. Ann. Rheum. Dis., 57,231-236, 1998.

48.    Uria, J. A., Balbin, M., Lopez,J. M., Alvarez, J., Vizoso,F.,Takigawa, M. and Lopez, O.C.: Collagenase-3 (MMP-13) expressioninchondrosarcoma cells and its regulation by basic fibroblast growth factor.Am.J. Pathol., 153, 91-101, 1998.

49.    Ishizeki, K., Nomura, S., Takigawa, M., Shioji, H. and Nawa,T.:Expression of osteopontin in Meckel's cartilage cells during phenotypictransdifferentiationin vitro, as detected by in situ hybridization and immunocytochemicalanalysis.Histochem. Cell Biol., 110, 457-466, 1998.

50.    Ikeda, T., Kubo, T., Arai, Y., Nakanishi, T., Kobayashi,K.,Takahashi, K., Imanishi, J., Takigawa, M. and Hirasawa, Y.:Adenovirus-mediatedgene delivery to the joints of guinea pigs. J. Rheum., 25,1666-1673, 1998.

51.    Maeda, S., Miyawaki, T., Nakanishi, T., Takigawa, M. and Shimada,M.:Peripheral type benzodiazepine receptor in T lymphocyte rich preparation.LifeSciences, 63, 1423-1430, 1998.

52.    Tamatani, T., Kobayashi, H., Tezuka, K., Sakamoto, S., Suzuki,K.,Nakanishi, T., Takigawa, M. and Miyano, T.: Establishment of theenzyme-linkedimmunosorbent assay for connective tissue growth factor (CTGF) anditsdetection in the sera of biliary atresia. Biochem. Biophys. Res. Commun.,251, 748-752, 1998.

53.    Ohnishi, H., Oka, T., Kusachi, S., Nakanishi,T., Takeda, K.,Nakahama, M., Doi, M., Murakami, T., Ninomiya, Y., Takigawa, M.and Tsuji, T.:Increased expression of connective tissue growth factor in theinfarct zone ofexperimentally induced myocardial infarction in rats. J. Mol.Cell Cardiol. 30,2411-2422, 1998.

54.    Yutani, Y., Yano, Y., Ohashi, H., Takigawa, M. and Yamano,Y.:Cartilaginous differentiation in the joint capsule.  J. Bone Miner. Metab., 17, 7-10, 1999.

55.    Kuboki, T., Hattori, T., Mizushima, T., Kanyama, M., Fujisawa,T.,Yamashita, A. and Takigawa, M.: Detection of specific antibodies againsthumancultured chondrosarcoma (HCS-2/8) and osteosarcoma (Saos-2) cells in theserumof patients with osteoarthritis of the temporomandibular joint. Arch.OralBiol., 44, 403-414, 1999.

56.    Kuboki, T., Nakanishi, T., Kanyama, M., Sonoyama, W., Fujisawa,T.,Kobayashi, K., Ikeda, T., Kubo, T., Yamashita, A. and Takigawa, M.:Directadenovirus-mediated gene delivery to the temporomandibular jointinguinea-pigs. Arch. Oral Biol., 44, 701-709, 1999.

57.    Fujisawa, T., Hattori, T., Takahashi, K.,Kuboki, T., Yamashita, A.and Takigawa, M.: Cyclic mechanical stress inducesextracellular matrixdegradation in cultured chondrocytes via gene expression ofmatrixmetalloproteinases and interleukin-1. J. Biochem., 125, 966-975, 1999.

58.    Kubo, T., Arai, Y., Takahashi, K., Ishida, T., Fujisawa,T.,Takigawa, M., Imanishi, J. and Hirasawa, Y.: Effect of pressure loading onInterleukin-8production in chondrocytes. Pathophysiology, 6, 35-39, 1999.

59.    Kubota, S., Hattori, T. Nakanishi, T. and Takigawa, M.:Involvementof cis-acting repressive element(s) in the 3'-untranslated region ofhumanconnective tissue growth factor gene. FEBS Lett., 450, 84-88, 1999.

60.    Kondo, Y., Nakanishi, T., Takigawa, M. and Ogawa,N.:Immunohistochemical localization of connective tissue growth factor in theratcentral nervous system. Brain Res., 834, 146-151, 1999.

61.    Shimo, T., Nakanishi, T., Nishida, T., Asano, M., Kanyama,M.,Kuboki, T., Tamatani, T., Tezuka, K., Takemura, M., Matsumura, T. andTakigawa,M.: Connective tissue growth factor induces the proliferation,migration andtube formation of vascular endothelial cells in vitro andangiogenesis in vivo.J. Biochem., 126, 137-145, 1999.

62.    Kubota, S., Copeland,T.D. and Pomerantz, R.J.: Nuclear andnucleolartargeting of human ribosomal protein S25: Common features shared withHIV-1regulatory proteins.  Oncogene,18,1503-1514, 1999.

63.    Kubota, S., Zhang, H., Kitahara, S. and Pomerantz, R.J.: Roleoflentiviral lytic polypeptide ・(LLP-・) in the selective cytotoxicity of γ-glutamylcysteine ethyl ester againsthumanimmunodeficiency virus type 1-producing cells. Antiviral Chemistry&Chemotherapy, 10, 121-127, 1999.

64.    Mori, T., Kawara, S., Shinozaki, M., Hayashi, N., Kakinuma,T.,Igarashi, A., Takigawa, M., Nakanishi, T. and Takehara, K.: Roleandinteraction of connective tissue growth factor with transforming growthfactor-β in persistent fibrosis: Amouse fibrosis model.  J. Cell.Physiol., 181, 153-159, 1999.

65.    Kanyama, M., Kuboki, T., Kojima, S., Fujisawa,T., Hattori, T.,Takigawa, M. and Yamashita, A.: Matrix metalloproteinases andtissue inhibitorsof metalloproteinases in synovial fluids of temporomandibularjointosteoarthritis patients. J. Orofac. Pain, 14, 20-30, 1999.

66.    Fujiwara, K., Udono, H., Kunisada, T., Kawai, A., Inoue,H.,Takigawa, M., Namba, M. and Nakayama, E.: Electrophoretic andserologiccharacterization of 56 kDa antigen (M56) with autologous serum derivedfrom achondrosarcoma patient; a shared antigen of immunoresponses in cancerandautoimmune diseases. Electrophoresis, 20, 3335-42,1999.

67.    Arai, Y., Kubo, T., Kobayashi, K., Ikeda, T., Takahashi,K.,Takigawa, M., Imanishi, J. and Hirasawa, Y.: Control of deliveredgeneexpression in chondrocytes using heat shock protein 70B promoter.J.Rheumatol., 26,1769-74, 1999.

68.    Sato, S., Nagaoka, T., Hasegawa, M., Tamatani, T., Nakanishi,T.,Takigawa, M. and Takehara, K.: Serum levels of connective tissue growthfactorare elevated in patients with systemic sclerosis: Association with theextentof skin sclerosis and the severity of pulmonary fibrosis. J. Rheumatol.,27,149-154, 2000. 

69.    Nishida, T., Nakanishi, T., Asano, M., Shimo, T. and Takigawa,M.:Effects of CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, ontheproliferation and differentiation of osteoblastic cells in vitro. J.Cell.Physiol., 184, 197-206, 2000.

70.    Nakanishi, T., Nishida, T., Shimo, T., Kobayashi, K., Kubo,T.,Tamatani, T., Tezuka, K. and Takigawa, M.: Effects of CTGF/Hcs24, a productofa hypertrophic chondrocyte-specific gene, on the proliferationanddifferentiation of chondrocytes in culture. Endocrinology, 141, 264-273,2000.

71.    Ikeda, T., Kubo, T., Nakanishi, T., Arai, Y., Kobayashi, K., Mazda,O.,Ohashi, S., Takahashi, K., Imanishi, J., Takigawa, M. and Hirasawa, Y.:Exvivogene delivery using an adenovirus vector in treatment for cartilagedefects. J.Rheumatol., 27, 990-996, 2000.

72.    Asaumi, K., Nakanishi, T., Asahara, H., Inoue, H. and Takigawa,M.:Expression of neurotrophins and their receptors(TRK)during fracturehealing.Bone, 26, 625-633, 2000.

73.    Shakunaga, T., Ozaki, T., Ohara, N., Asaumi, K., Doi, T.,Nishida,K., Kawai, A., Nakanishi, T., Takigawa, M.and Inoue, H.: Expressionofconnective tissue growth factor in cartilaginous tumors. Cancer, 89,1466-1473,2000.

74.    Kubota, S., Hattori, T., Shimo, T., Nakanishi, T. and Takigawa,M.:Novel intracellular effects of human connective tissue growth factorexpressedin Cos-7 cells. FEBS Lett., 474, 58-62, 2000.

75.    Kubota, S. and Pomerantz, R.J.: The nuclear function of thenucleardiffusion inhibitory signal(NIS)of HIV-1: Critical roles in dominant nuclearlocalization and intraclluarstability. J. Hum. Virol.,  3, 173-181,2000.

76.    Hattori, T., Takahashi, K., Yutani, Y., Fujisawa,T., Nakanishi, T.and Takigawa, M.: Rheumatoid arthritis related antigen 47kDa(RA-A47) is aproduct of colligin-2 and acts as a human HSP47. J. Bone Miner.Metab. 18,328-334, 2000.

77.    Kubota, S., Kondo, S., Eguchi, T., Hattori, T., Nakanishi,T.,Pomerantz, R.J. and Takigawa, M.: Identification of an RNA element thatconferspost-transcriptional repression of connective tissue growthfactor/hypertrophicchondrocyte specific 24 (ctgf/hcs24) gene: Similarities toretroviralRNA-protein interactions. Oncogene, 19,4773-4786, 2000.

78.    Kondo, S., Kubota, S., Eguchi, T., Hattori, T., Nakanishi,T.,Sugawara, T. and Takigawa, M.: Characterization of a mouse ctgf 3'-UTRsegmentthat mediates repressive regulation of gene expression. Biochem.Biophys. Res.Commun., 278, 119-124, 2000.

79.    Kobayashi, H., Hirashima, Y., Wei Sun, G., Fujie, M., Nishida,T.,Takigawa, M. and Terao, T.: Identity of urinary trypsininhibitor-bindingprotein to link protein. J. Biol. Chem., 275, 21185-21190,2000.

80.    Ghayor, C., Herrouin, J.H., Chadjichristos, C., Ala-Kokko,L.,Takigawa, M., Pujol, J.P. and Galera, P.: Regulation of Human COL2A1GeneExpression in Chondrocytes; indentification of C-Krox-Responsive elementsand modulationby phenoytpe alteration. J. Biol. Chem., 275, 27421-27438, 2000.

81.    Miyazaki, I.,Aoki-Sogawa, C., Asanuma, M., Higashi, Y., Tanaka, K.,Nakanishi, T. and Ogawa,N.: Expression of metallothionein-・ mRNA and its regulation bylevodopa in the basal ganglia ofhemi-parkinsonian rats. Neuroscience Letters,293, 65-68, 2000.