原 著
234) Kondo, S., Kubota, S., Mukudai, Y., Nishida, T., Yoshihama, Y., Shirota, T., Shintani, S. and Takigawa M.: Binding of glyceraldehyde-3-phosphate dehydrogenase to the cic-acting element of structure-anchored repression in Ccn2 mRNA. Biochem. Biophys. Res. Commun., 405, 382-387, 2011
235) Nishida, T., Emura, K., Kubota, S., Lyons, K. M., Takigawa, M. CCN family 2/ connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP). J. Bone Miner. Res. 26, 351-363, 2011.
236) Kubota, S. and Takigawa, M.: The role of CCN2 in cartilage and bone development. J. Cell Commun. Signal. 5, 209-217, 2011.
237) Ohgawara, T., Kubota, S., Kawaki, H., Kurio, N., Abd El Kader, T., Hoshijima, M., Janune, D., Shimo, T., Perbal, B., Sasaki, A. and Takigawa, M.: Association of the metastatic phenotype with CCN family members among breast and oral cancer cell. J Cell Commun Signal. 5, 291-299, 2011
238) Janune, D., Kubota, S., Lazar, N., Perbal, B., Iida, S. and Takigawa M.: CCN3-mediated promotion of sulfated proteoglycan synthesis in rat chondrocytes from developing joint heads. J. Cell Commun. Signal. 5, 167-171, 2011.
239) Miyake, Y., Furumatsu, T., Kubota, S., Kawata, K., Ozaki, T. and Takigawa M.: Mechanical strech increases CCN2/CTGF expression in anterior cruciate ligament-derived cells. Biochem. Biophys. Res. Commun., 409, 247-252, 2011.
240) Kodama, T., Takehara,T., Hikita, H., Shimizu, S., Shigekawa, M., Tsunematsu, H., Li, W., Miyagi, T., Hosui, A., Tatsumi, T., Ishida, H., Kanto, T., Hiramatsu, N., Kubota, S., Takigawa, M., Tomimaru, Y., Tomokuni, A., Nagano, H., Doki, Y., Mori, M. and Hayashi, N.: Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice. J. Clin. Invest., 121, 3343-3356, 2011.
241) Kawaki, H., Kubota, S., Suzuki, A., Suzuki, M., Kohsaka, K., Hoshi, K., Fujii, T., Lazar, N., Ohgawara, T., Maeda, T., Perbal, B., Takano-Yamamoto, T. and Takigawa, M.: Differential roles of CCN family proteins during osteoblast differentiation: involvement of Smad and MAPK signaling pathways. Bone, 49, 975-989, 2011.
242) Janune, D., Kubota, S., Nishida, T., Kawaki, H., Perbal, B., Iida, S. and Takigawa, M.: Novel effects of CCN3 that may direct the differentiation of chondrocytes. FEBS Lett. 585, 3033-3040, 2011
243) Nishida, T., Kubota, S., Aoyama, E., Janune, D., Maeda, A. and Takigawa, M.: Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 productions by chondrocytes. Endocrinology. 152, 4232-4241, 2011.
244) Shimo, T., Nishiyama, A., Kubota, S., Kurio, N., Okui, T., Hassan, N.M. M., Honami, T., Kishimoto, K., Mese, H., Takigawa, M. and Sasaki. A. Novel pathogenic role of fibrin as revealed by a case study on ligneous gingivitis. Oral Science International. 8, 44-49, 2011
245) Surmann-Schmitt, C., Sasaki, T., Hattori, T., Eitzinger, N., Schett, G., von der Mark, K., and Stock, M. The Wnt antagonist Wif-1 interacts with CTGF and inhibits CTGF activity. J Cell Physiol. 27:2207-2216, 2012.
246) Kawata., K., Kubota, S., Eguchi, T., Aoyama, E., Moritani, N., Kondo, S., Nishida, T. and Takigawa, M. Role of low-density lipoprotein receptor related protein 1 (LRP1) in CCN2/connective tissue growth factor (CTGF) protein transport in chondrocytes. J Cell Sci, 15, 2965-2972, 2012
247) Furumatsu T, Kanazawa T, Miyake Y, Kubota S, Takigawa M, Ozaki T.Mechanical stretch increases Smad3-dependent CCN2 expression in inner meniscus cells. J Orthop Res. 30(11), 1738-1745, 2012
248) Hoshijima M, Hattori T, Aoyama E, Nishida T, Yamashiro T, Takigawa M. Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2interactions in expression of the differentiated phenotype of chondrocytes. FEBS J, 279(19), 3584-3597, 2012
249) Honjo T, Kubota S, Kamioka H, Sugawara Y, Ishihara Y, Yamashiro T, Takigawa M, Takano-Yamamoto T. Promotion of Ccn2 expression and osteoblastic differentiation by actin polymerization, which is induced by laminar fluid flow stress. J Cell Commun Signal, 6(4), 225-232, 2012
250) Aoyama E, Kubota S, Takigawa M. CCN2/CTGF binds to fibroblast growth factor receptor 2 and modulates its signaling. FEBS Lett, 586, 4270-4275, 2012.
251) Abd El Kader T, Kubota S, Janune D, Nishida T, Hattori T, Aoyama E, Perbal B, Kuboki T, Takigawa M. Anti-fibrotic effect of CCN3 accompanied by altered gene expression profile of the CCN family. J Cell Commun Signal,7, 11-18, 2013.
252) Hara ES, Ono M, Kubota S, Sonoyama W, Oida Y, Hattori T, Nishida T, Furumatsu T, Ozaki T, Takigawa M, Kuboki T. Novel chondrogenic and chondroprotective effects of the natural compound harmine. Biochimie, 95, 374-381, 2013.
253) Nishida, T., Kubota, S., Aoyama, E. and Takigawa, M.: Impaired glycolytic metabolism causes chondrocyte hypertrophy-like changes via promotion of phospho-Smad1/5/8 translocation into nucleus. Osteoarthritis Cartilage, 21, 700-709, 2013.
254) Tomita, N., Hattori, T., Ito, S., Aoyama, E., Yao, M., Yamashiro, T. and Takigawa M.: Cartilage–specific overexpression of CCN family member 2/connective tissue growth factor (CCN2/CTGF) stimulates insulin-like growth factor expression and bone growth. PLoS One, 8, e59226, 2013.
255) Sumiyoshi, K., Kubota, S., Ohgawara, T., Kawata, K., Abd El Kader, T., Nishida, T., Ikeda, N., Shimo, T., Yamashiro, T. and Takigawa, M.: Novel role of miR-181a in cartilage metabolism. J. Cell. Biochem., 114, 2094-2100, 2013.
256) Nakagawa, Y., Minato, M., Sumiyoshi, K., Maeda, A., Hara, C., Murase, Y., Nishida, T., Kubota, S. and Takigawa, M.: Regulation of CCN1 via the 3’-untranslated region. J. Cell Commun. Signal., 7, 207-217, 2013.
257) Itoh, S., Hattori, T., Tomita, N., Aoyama, E., Yutani,Y., Yamashiro, T. and Takigawa, M.: CCN family member 2/connective tissue growth factor (CCN2/CTGF) has anti-aging effects that protect articular cartilage from age-related degenerative changes. PLoS One, 8, e71156, 2013.
258) Hattori, T., Kishino, T., Stephen, S., Eberspaecher, H., Maki, S., Takigawa, M., de Crombrugghe, B. and Yasuda, H.: E6-AP/UBE3A protein acts as a ubiquitin ligase toward sox9 protein. J. Biol. Chem., 288, 35138-35148, 2013.
259) Hara ES, Ono M, Eguchi T, Kubota S, Pham HT, Sonoyama W, Tajima S, Takigawa M, Calderwood SK, Kuboki T.: miRNA-720 Controls Stem Cell Phenotype, Proliferation and Differentiation of Human Dental Pulp Cells.PLos One,8,e/83545,2013.
260) Abd El Kader, T., Kubota, S., Nishida, T., Hattori, T., Aoyama, E., Janune, D., Hara, E. S., Ono, M., Tabata, Y., Kuboki, T. and Takigawa, M.: The regenerative effects of CCN2 independent modules on chondrocytes in vitro and osteoarthritis models in vivo. Bone,59,180-8 2014.
261) Zaman F, Chrysis D, Huntjens K, Chagin A, Takigawa M, Fadeel B, Sävendahl L.:Dexamethasone differentially regulates Bcl-2 family proteins in human proliferative chondrocytes: Role of pro-apoptotic Bid. Toxicol Lett. 224(2):196-200. 2014.
262) Kondo S, Mukudai Y, Soga D, Nishida T, Takigawa M, Shirota T: Differential expression of vascular endothelial growth factor in high- and low- metastasis cell lines of salivary gland adenoid cystic carcinoma. Anticancer Res. 34(2):671-7. 2014.
263) Perbal B, Trackman P, Castellot J, Brigstock D, Takigawa M, Lau L, Leask A.: Report on the 7(th) international workshop on the CCN family of genes : October 16-19, 2013-Nice, France. J Cell Commun Signal.,8(1),71-6,2014.
264) Maeda-Uematsu, A., Kubota, S., Kawaki, H., Kawata, K., Miyake, Y., Hattori, T., Nishida, T., Moritani, N., Lyons, K. M., Iida, S. and Takigawa, M.: CCN2 as a novel molecule supporting energy metabolism of chondrocytes. J. Cell Biochem.,115(5),854-65.2014.
265) Charrier A, Chen R, Chen L, Kemper S, Hattori T, Takigawa M and Brigstock DR: Connective tissue growth factor (CCN2) and microRNA-21 are components of a positive feedback loop in pancreatic stellate cells (PSC) during chronic pancreatitis and are exported in PSC-derived exosomes. J Cell Commun. Signal.,8(2),147-56 2014.
266) Abd El Kader, T., Kubota, S., Anno, K., Tanaka, S., Nishida, T., Furumatsu, T., Aoyama, E., Kuboki, T., Takigawa, M. : Direct interaction between CCN family protein 2 and fibroblast growth factor 1. J. Cell Commun. Signal., 8, 157-163, 2014.
267) Nishida, T., Kubota, S., Aoyama, E., Janune, D., Lyons, K. M., Takigawa, M.: CCN family protein 2 (CCN2) promotes the early differentiation, but inhibits the terminal differentiation of skeletal myoblasts. J Biochem., 157, 91-100, 2015.
268) Aoyama, E., Kubota, S., Khattab, H. M., Nishida, T., Takigawa, M.: CCN2 enhances RANKL-induced osteoclast differentiation via direct binding to RANK and OPG. Bone, 73, 242-248, 2015.
269) Hara, E. S., Ono, M., Hai, P. T., Sonoyama, W., Kubota, S., Takigawa, M., Matsumoto, T., Young, M. F., Olsen, B. R., Kuboki, T.: Fluoinolone acetonide is a potent synergistic factor of TGF-b3-associated chondrogenesis of bone marrow-derived mesenchymal stem cells for articular surface regeneration. J. Bone Miner. Res., 30,1585-1596, 2015.
270) Park, J., Gebhardt, M., Golovchenko, S., Perez Branguli, F., Hattori, T., Hartmann, C., Zhou, X., de Crombrugghe, B., Stock, M., Schneider, H., von der Mark, K.: Dual pathways to endochondral osteoblasts: A novel chondrocyte-derived cell identified in hypertrophic cartilage. Biology Open, 4, 608-621. 2015.
271) Khattab, H.M., Aoyama, E., Kubota, S., Takigawa, M. Physical interaction of CCN2 with diverse growth factors involved in chondrocyte differentiation during endochondral ossification. J. Cell Commun. Signal. 9, 247-254. 2015.
272) Takeuchi-Igarashi, H., Kubota, S., Tachibana, T., Murakashi, E., Takigawa, M., Okabe, M., Numabe, Y.: Matrix remodeling response of human periodontal tissue cells toward fibrosis upon nicotine exposure. Odontology, 104, 35-43, 2016.
273) Kawai, M., Liu, N., Hattori, T., Kataoka, Y-H., Takigawa, M., Kubota, S., Yamamoto, T. and Ohura, K.: Sorcin expression in the epiphyseal growth plates of mice. J. Hard Tissue Biol., 25, 57-62, 2016.
274) Murase, Y,, Hattori, T., Aoyama, E., Nishida, T., Maeda-Uematsu, A., Kawaki, H., Lyons, K. M., Sasaki, A., Takigawa, M., Kubota, S.: Role of CCN2 in amino acid metabolism of chondrocytes. J. Cell Biochem., 117, 927-937, 2016.
275) Hara, C., Kubota, S., Nishida, T., Hiasa, M., Hattori, T., Aoyama, E., Moriyama, Y., Kamioka, H., Takigawa, M. : Involvement of multiple CCN family members in platelets that support regeneration of joint tissues. Mod. Rheumatol., 21, Apr, 1-10, 2016.
276) Shimo, T., Matsumoto, K., Takabatake, K., Aoyama, E., Takebe, Y., Ibaragi, S., Okui, T., Kurio, N., Takada, H., Obata, K., Pang, P., Iwamoto, M., Nagatsuka, H., Sasaki, A. : The role of sonic hedgehog signaling in osteoclastogenesis and jaw bone destruction. PLoS One. 2016 Mar 23;11(3):e0151731.
277) Eguchi, T., Calderwood, S. K., Takigawa, M., Kubota, S., Kozaki, K. I. : Intracellular MMP3 promotes HSP gene expression in collaboration with chromobox proteins. J. Cell Biochem. 118, 43-51, 2016.
278) Janune, D., Abd El Kader, T., Aoyama, E., Nishida, T., Tabata, Y., Kubota, S., Takigawa, M. : Novel role of CCN3 that maintains the differentiated phenotype of articular cartilage. J. Bone Miner. Metab., 35, 582-597, 2017.
279) Nishida, T., Kubota, S., Aoyama, E., Yamanaka, N., Lyons, K. M., Takigawa, M.: Low-intensity pulsed ultrasound (LIPUS) treatment of cultured chondrocytes stimulates production of CCN family protein 2 (CCN2), a protein involved in the regeneration of articular cartilage: mechanism underlying this stimulation. Osteoarthritis Cartilage, 25, 759-769, 2017.
280) El-Seoudi, A., Abd El Kader, T., Nishida, T., Eguchi, T., Aoyama, E., Takigawa, M., Kubota, S.: Catabolic effects of FGF-1 on chondrocytes and its possible role in osteoarthritis. J. Cell Commun. Signal., 11, 255-263, 2017.
281) Kawata, K., Kubota, S., Eguchi, T., Aoyama, E., Moritani, N.H., Oka, M., Kawaki H., Takigawa. M.: A tumor suppressor gene product, platelet-derived growth factor receptor-like protein controls chondrocyte proliferation and differentiation. J. Cell. Biochem. 118, 4033-4044, 2017.
282) Hori A, Nishida T, Takashiba S, Kubota S, Takigawa M.: Regulatory mechanism of CCN2 production by serotonin (5-HT) via 5-HT2A and 5-HT2B receptors in chondrocytes. PLoS One,12(11):e0188014, 2017.
283) Akashi S, Nishida T, El-Seoudi A, Takigawa M, Iida S, Kubota S.: Metabolic regulation of the CCN family genes by glycolysis in chondrocytes. J. Cell Commun. Signal.,12, 245-252, 2018.
284) Ishikawa T, Nishida T, Ono M, Takarada T, Ha N, Kurihara S, Furumatsu T, Murase Y, Takigawa M, Oohashi T, Kamioka H, Kubota S.: Physiological role of urothelial cancer-associated 1 long noncoding RNA in human skeletogenic cell differentiation. J. Cell. Physiol., 233, 4825-4840, 2018.
285) Hara ES, Okada M, Nagaoka N, Hattori T, Kuboki T, Nakano T, Matsumoto T.: Chondrocyte membrane nanofragments are nucleation site for mineralization. ACS Biomaterials Science & Engineering, ACS Biomater. Sci. Eng., 4, 617–625, 2018.
286) Hara ES, Okada M, Nagaoka N, Hattori T, Iida LM, Kuboki T, Nakano T, Matsumoto T.: Chondrocyte burst promotes space for mineral expansion. Integr Biol (Camb). 10, 57-66,2018.
287) Ohta K, Aoyama E, Ahmad SAI, Ito N, Anam MB, Kubota S, Takigawa M.: CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi. J. Cell Commun. Signal., 13, 113-118, 2019.
288) Kamatsuki, Y, Aoyama, E., Furimatsu, T., Miyazawa, S., Maehara, A., Yamanaka, N., Nishida, T., Kubota, S., Ozaki, T., Takigawa, M. : Possible reparative effect of low-intensity pulsed ultrasound (LIPUS) on injured meniscus. J. Cell Commun. Signal., 13, 193-207, 2019.
289) Uchida, Y., Irie, K., Fukunaga, D., Kataoka, K., Hattori, T., Ono, M., Ekuni, D., Kubota, S., Morita, M. :Commensal microbiota enhance both osteoclast and osteoblast activities. Molecules, 2018.
290) Fu, S., Kuwahara, M., Uchida, Y., Koudo, S., Hayashi, D., Shimomura, Y., Takagaki, A., Nishida, T., Maruyama, Y., Ikegame, M., Hattori, A., Kubota, S., Hattori, T. : Circadian production of melatonin in cartilage modifies rhythmic gene expression. J. Endocrinol. 241, 161-173, 2019.
291) Nishida, T., Kubota, S., Yokoi, H., Mukoyama, M., Takigawa, M. : Roles of matricellular CCN2 deposited by osteocytes in osteoclastogenesis and osteoblast differentiation. Sci. Rep., 9(1):10913, 2019.
292) Nishida, T., Nagao, Y., Hashitani, S., Yamanaka, N., Takigawa, M., Kubota, S. : Suppression of adipocyte differentiation by low-intensity pulsed ultrasound via inhibition of insulin signaling and promotion of CCN family protein 2. J. Cell. Biochem. 10, 1002, 2020.
293) Hoshijima, M., Hattori, T., Aoyama, E., Nishida, T., Kubota, S., Takigawa, M. : Roles of interaction between CCN2 and Rab14 in aggrecan production by chondrocytes. Int. J. Mol. Sci. 21 (8) E2769, 2020.
294) 近藤 星：長鎖(約6kb) lssODNおよびCRISPR/Cas9を用いたヒト科霊長類特異的lncRNAのマウス受精卵へのエレクトロポレーションによるノックイン。岡山歯学会雑誌、39(1), 1-14, 2020.
295) Akashi, S., Nishida, T., Mizukawa, T., Kawata, K., Takigawa, M., Iida, S., Kubota, S. : Regulation of cellular communication factor 2 (CCN2) in breast cancer cells via the cell-type dependent interplay between CCN2 and glycolysis. J. Oral Biosci. S1349-0079(20)30090-6, 2020.
296) Kuwahara, M., Kadoya, K., Kondo, S., Fu, S., Miyake, Y., Ogo, A., Ono, M., Furumatsu, T,, Nakata, E., Sasaki, T., Minagi, S., Takigawa, M., Kubota, S., Hattori, T. : CCN3 (NOV) drives degradative changes in aging articular cartilage. Int. J. Mol. Sci. 21(20) E7556, 2020.
297) El-Seoudi, A., Nishida, T., Mizukawa, T., Hattori, T., Kawata, K., Taha, E. A., Takigawa, M., Kubota, S. : Bipartite regulation of cellular communication network factor 2 and fibroblast growth factor 1 genes by fibroblast growth factor 1 through histone deacetylase 1 and fork head box protein A1. J. Cell Commun. Signal., 15(1), 81-91, 2021.
298) Mizukawa, T., Nishida, T., Akashi, S., Kawata, K., Kikuchi, S., Kawaki, H., Takigawa, M., Kamioka, H., Kubota, S. : RFX1-mediated CCN3 induction that may support chondrocyte survival under starved conditions. J. Cell. Physiol. 2021.
