OKAYAMA UNIVERSITY Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

岡山大学大学院医歯薬学総合研究科 病態制御科学専攻 腫瘍制御学講座 免疫学

  • 岡山大学 歯学部
  • (独)理化学研究所

研究業績

2016~

  • Hirayama T, Nagata Y, Nishida M, Matsuo M, Kobayashi S, Yoneda A, Kanetaka K, Udono H, Eguchi S. Metformin Prevents Peritoneal Dissemination via Immune-suppressive Cells in the Tumor Microenvironment. Anticancer Res. 39(9): 4699-4709, 2019.
  • Takahara M, Takaki A, Hiraoka S, Adachi T, Shimomura Y, Matsushita H, Nguyen TTT, Koike K, Ikeda A, Takashima S, Yamasaki Y, Inokuchi T, Kinugasa H, Sugihara Y, Harada K, Eikawa S, Morita H, Udono H, Okada H. Berberine improved experimental chronic colitis by regulating interferon-γ- and IL-17A-producing lamina propria CD4+ T cells through AMPK activation. Sci Rep. 9 (1): 11934, 2019.
  • Uehara T, Eikawa S, Nishida M, Kunisada Y, Yoshida A, Fujiwara T, Kunisada T, Ozaki T, and Udono H. Metformin induces CD11b+ cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and antitumor effects. Int Immunology, 31(4): 187-198, 2019.
  • Miyakoda M, Bayarsaikhan G, Kimura D, Akbari M, Udono H, Yui K. Metformin Promotes the Protection of Mice Infected with Plasmodium yoelii Independently of γδ T Cell Expansion. Frontiers in Immunology, 9: 2942, 2018.
  • Kubo T, Ninomiya T, Hotta K, Kozuki T, Toyooka S, Okada H, Fujiwara T, Udono H, Kiura K. Study Protocol: Phase-Ib Trial of Nivolumab Combined With Metformin for Refractory/Recurrent Solid Tumors. Clin Lung Cancer, 19 (6): e861-e864, 2018.
  • Kajiwara C, Kusaka Y, Kimura S, Yamaguchi T, Nanjo Y, Ishii Y, Udono H, Standiford T. J, Tateda K. Metformin Mediates Protection against Legionella Pneumonia through Activation of AMPK and Mitochondrial Reactive Oxygen Species. J Immunol, 200 (2): 623-631, 2018.
  • Bhatia A, O’Brien K, Guo J, Gor V, Kajiwara C, Chen M, Woodley D, Udono H, Wei Li. Extracellular and Non-Chaperone Function of Heat Shock Protein-90 alpha (Hsp90α) is Required for Skin Wound Healing. J Invest Dermatol, 138 (2): 423-433, 2018.
  • Kunisada Y, Eikawa S, Tomonobu N, Domae S, Uehara T, Hori S, Furusawa Y, Hase K, Sasaki A, Udono H. Attenuation of CD4+CD25+regulatory T cells in the tumor microenvironment by metformin, a type 2 diabetes drug. EBioMedicine (launched by Cell Press and The Lancet), 25: 154-164, 2017.
  • Hong F, Mohammad Rachidi S, Lundgren D, Han D, Huang X, Zhao H, Kimura Y, Hirano H, Ohara O, Udono H, Meng S, Liu B, Li Z. Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90. PLoS One, 12(1): e0169260, 2017.
  • Watanabe M, Yamamoto H, Eikawa S, Shien K, Shien T, Soh J, Hotta K, Wada J, Hinotsu S, Fujiwara T, Kiura K, Doihara H, Miyoshi S, Udono H, Toyooka S. Study about the Efficacy of Metformin to Immune Function in Cancer Patients. Acta Medica Okayama, 70(4): 327-30, 2016.
  • Ohta T, Sugiyama M, Hemmi H, Yamazaki C, Okura S, Sasaki I, Fukuda Y, Orimo T, Ishii KJ, Hoshino K, Ginhoux F, Kaisho T. Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis. Sci Rep, 6: 23505, 2016.
  • Ariyoshi Y, Watanabe M, Eikawa S, Yamazaki C, Sadahira T, Hirata T, Araki M, Ebara S, Nasu Y, Udono H, Kumon H. The induction of antigen-specific CTL by in situ Ad-REIC gene therapy. Gene Ther, 23(5): 408-414, 2016.
  • Kitano M, Yamazaki C, Takumi A, Ikeno T, Hemmi H, Takahashi N, Shimizu K, Fraser SE, Hoshino K, Kaisho T, Okada T. Imaging of the cross-presenting dendritic cell subsets in the skin-draining lymph node. Proc Natl Acad Sci USA, 113(4): 1044-1049, 2016.

2011~2015

  • Acquah J-R Q, Haratake K, Rakwal R, Udono H, Chiba T. Hsp90 and ECM29 Are Important to Maintain the Integrity of Mammalian 26S Proteasome. Adv Biol Chem, 5(7): 255-265, 2015.
  • Kurose K, Ohue Y, Sato E, Yamauchi A, Eikawa S, Isobe M, Nishio Y, Uenaka A, Oka M, Nakayama E. Increase in activated Treg in TIL in lung cancer and in vitro depletion of Treg by ADCC using an antihuman CCR4 mAb (KM2760). J Thorac Oncol, 10(1): 74-83, 2015.
  • Kurose K, Ohue Y, Wada H, Iida S, Ishida T, Kojima T, Doi T, Suzuki S, Isobe M, Funakoshi T, Kakimi K, Nishikawa H, Udono H, Oka M, Ueda R, Nakayama E. Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients. Clin Cancer Res, 21(19): 4327-4336, 2015.
  • Miyai M, Eikawa S, Hosoi A, Iino T, Matsushita H, Isobe M, Uenaka A, Udono H, Nakajima J, Nakayama E, Kakimi K. Detection and Tracking of NY-ESO-1-Specific CD8+ T Cells by High-Throughput T Cell Receptor ? (TCRB) Gene Rearrangements Sequencing in a Peptide-Vaccinated Patient. PLoS One, 10(8): e0136086, 2015.
  • Uehara T, Fujiwara T, Takeda K, Kunisada T, Ozaki T, Udono H.  Immunotherapy for Bone and Soft Tissue Sarcomas.  Bio Med Res Int, 2015: 820813, 2015.
  • Eikawa S, Nishida M, Mizukami S, Yamazaki C, Nakayama E and Udono H. Immune-mediated anti-tumor effect by type 2 diabetes drug, metformin. Proc Natl Acad Sci USA, 112(6): 1809-1814, 2015.
  • Ichiyanagi T, Ichiyanagi K, Ogawa A, Kuramochi-Miyagawa S, Nakano T, Chuma S, Sasaki H, Udono H.  HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse. Nucleic Acids Res, 42(19): 11903-11911, 2014.
  • Eikawa S, Udono H. Monitoring multifunctionality of immune-exhausted CD8 T cells in cancer bearing patients. Methods in Mol Biol, 1142: 11-17, 2014.
  • Wada H, Isobe M, Kakimi K, Mizote Y, Eikawa S, Sato E, Takigawa N, Kiura K, Tsuji K, Iwatsuki K, Yamasaki M, Miyata H, Matsushita H, Udono H, Seto Y, Yamada K, Nishikawa H, Pan L, Venhaus R, Doki Y, Oka M, Nakayama E. Vaccination with NY-ESO-1 overlapping peptides mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing NY-ESO-1 antigen. J Immunother, 37(2): 84-92, 2014.
  • Yamazaki C, Sugiyama M, Ohta T, Hemmi H, Hamada E, Sasaki I, Fukuda Y, Yano T, Nobuoka M, Hirashima T, Iizuka A, Sato K, Tanaka T, Hoshino K, Kaisho T. Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1. J Immunol, 190(12): 6071-6082, 2013.
  • Eikawa S, Kakimi K, Isobe M, Kuzushima K, Luescher I, Ohue Y, Ikeuchi K, Uenaka A, Nishikawa H, Udono H, Oka M, Nakayama E. Induction of CD8 T-cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20-mer NY-ESO-1f (NY-ESO-1 91-110) peptide. Int J Cancer, 132(2): 345-354, 2013.
  • Ito S, Nagata Y, Susumu S, Yoneda A, Matsuo M, Yui K, Udono H, Eguchi S, Kanematsu T. Phenotypic analysis of monocyte-derived dendritic cells loaded with tumor antigen with heat shock cognate protein-70. Anticancer Res, 32(11): 4897-4904. 2012
  • Sasaki I, Hoshino K, Sugiyama T, Yamazaki C, Yano T, Iizuka A, Hemmi H,Tanaka T, Saito M, Sugiyama M, Fukuda Y, Ohta T, Sato K, Ainai A, Suzuki T, Hasegawa H, Toyama-Sorimachi N, Kohara H, Nagasawa T, Kaisho T. Spi-B is critical for plasmacytoid dendritic cell function and development. Blood, 120: 4733-4743, 2012.
  • Kajiwara C, Kondo S, Uda S, Dai L, Ichiyanagi T, Chiba T, Ishido S, Koji T and Udono H. Spermatogenesis arrest caused by conditional deletion of Hsp90α in adult mice. Biology Open (BIO), 1(10): 977?982, 2012.
  • Kato Y, Kajiwara C, Ishige I, Mizukami S, Yamazaki C, Eikawa S, Kakimi K. and Udono H. HSP70 and HSP90 differentially regulate translocation of extracellular antigen to the cytosol for cross-presentation. Autoimmune diseases, 2012: 745962, 2012.
  • Li Y, Li S, Hoshino M, Ishikawa R, Kajiwara C, Gao X, Zhao X, Ishido S, Udono H, and Wang JY. HSP90α deficiency does not affect Ig gene hypermutation and class switch but causes enhanced MHC class II Ag presentation. Int Immunol, 24(12): 751-758, 2012.
  • Mizukami S, Kajiwara C, Tanaka M, Kaisho T, Udono H. Differential MyD88/IRAK4 requirements for cross-priming and tumor rejection induced by hsp70-model Ag fusion protein. Cancer Sci, 103(5): 851-859, 2012.
  • Udono H. Heat shock protein magic in antigen trafficking within dendritic cells ? implications in antigen cross-presentation in Immunity. Acta Medica Okayama, 66(1): 1-6, 2012.
  • Imai T, Kato Y, Kajiwara C, Mizukami S, Ishige I, Ichiyanagi T, Hikida M, Wang JY, Udono H. HSP90 contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells. Proc Natl Acad Sci USA, 108(39): 16363-16368, 2011.

2006~2010

  • Ichiyanagi T, Imai T, Kajiwara C, Mizukami S, Nakai A, Nakayama T, Udono H. Essential role of endogenous HSP90 of dendritic cells in antigen cross-presentation. J Immunol, 185(5): 2693-2700, 2010.
  • Ohkusu-Tsukada K, Toda M, Udono H, Kawakami Y, Takahashi K. Targeted inhibition of IL-10-secreting CD25- Treg via p38 MAPK suppression in cancer immunotherapy.? Eur J Immunol, 40(4): 1011-1021, 2010.
  • Udono H, Ichiyanagi T, Mizukami S, Imai T. Heat Shock Proteins in Antigen Trafficking -Implications on Antigen Presentation to T cells. Int J Hyperthermia, 25(8): 617-625, 2009.
  • Yamano T, Mizukami S, Murata S, Chiba T, Tanaka K and Udono H. Hsp90 mediated assembly of the 26S proteasome is involved in major histocompatibility complex class I antigen processing. J Biol Chem, 283(42): 28060-28065, 2008.
  • Yamano T, Sugahara H, Mizukami S, Murata S, Chiba T, Tanaka K, Yui K and Udono H. Allele-selective effect of PA28 in MHC class I antigen processing. J Immunol, 181(3): 1655-1664, 2008.
  • Mizukami S, Kajiwara C, Hiroshi Ishikawa H, Katayama I, Yui K, and Udono H. Both CD4+ and CD8+ T cell epitopes fused to heat shock cognate protein 70 (hsc70) can function to eradicate tumors. Cancer Sci, 99(5) 1008-1015, 2008.
  • Susumu S, Nagata Y, Ito S, Matsuo M, Valmori D, Yui K, Udono H, Kanematsu T. Cross-presentation of NY-ESO-1 cytotoxic T lymphocyte epitope fused to human heat shock cognate protein 70 by dendritic cells. Cancer Sci, 99(1): 107-112. 2008.
  • Udono H, Wang J, Watanabe T. Antigen presentation to Lymphocytes. Encyclopedia of Life Sciences, January 2007, John Wiley & Sons, Ltd:

2001~2005

  • Honma K, Udono H, Kohno T, Yamamoto K, Ogawa A, Takemori T, Kumatori A, Suzuki S, Matsuyama T and Yui K. Interferon regulatory factor-4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS. Proc Natl Acad Sci USA, 102(44): 16001-16006, 2005.
  • Ohkusu-Tsukada K, Tominaga N, Udono H and Yui K. Regulation of the Maintenance of Peripheral T-Cell Anergy by TAB1-Mediated p38 Activation. Mol Cell Biol, 2416(16): 6957-6966, 2004.
  • Furukawa H, Doh-ura K, Okuwaki R, Shirabe S, Yamamoto K, Udono H, Ito T, Katamine S, Niwa M. A Pitfall in Diagnosis of Human Prion Diseases Using Detection of Protease-resistant Prion Protein in Urine. CONTAMINATION WITH BACTERIAL OUTER MEMBRANE PROTEINS. J Biol Chem, 279(22): 23661-23667, 2004.
  • Udono H, Saito T, Ogawa M, Yui K. Hsp-antigen fusion and their use for immunization. Methods, 32(1): 21-24, 2004.
  • Isomoto H, Oka M, Yano Y, Kanazawa Y, Soda H, Terada R, Yasutake T, Nakayama T, Shikuwa S, Takeshima F, Udono H, Murata I, Ohtsuka K, Kohno S. Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer. Cancer Lett, 198(2): 219-228, 2003.
  • Tominaga N, Ohkusu-Tsukada K, Udono H, Matsuyama T and Yui K. Development of Th1 and Th2 immune responses in mice lacking interferon regulatory factor-4. Int Immunol, 15(1): 1-10, 2003.
  • Kawabata Y, Udono H, Honma K, Ueda M and Yui K. Merozoite surface protein-1-specific immune response is protective against exoerythrocytic forms of Plasmodium yoelii. Infect Immunity, 70(11): 6075-6082, 2002.
  • Yamano T, Murata S, Shimbara N, Tanaka N, Chiba T, Tanaka K, Yui K and Udono H. Two distinct pathway mediated by PA28 and hsp90 in major histocompatibility complex class I antigen processing. J Exp Med, 196(2): 185-196, 2002.
  • Murata S, Udono H, Tanahashi N, Hamada N, Watanabe K, Adachi K, Yamano T, Yui K, Kobayashi N, Kasahara M, Tanaka K, Chiba T. Immunoproteasome assembly and antigen presentation in mice lacking both PA28a and PA28b. EMBO J, 20(21): 5898-5907, 2001.
  • Udono H, Yamano T, Kawabata Y, Ueda M and Yui K. Generation of cytotoxic T lymphocytes by MHC class I ligands fused to heat shock cognate protein 70 (hsc70). Int Immunol, 13(10): 1233-1242, 2001.
  • Sano I, Takahashi T, Koji T, Udono H, Yui K, Ayabe H. Prolonged survival of rat cardiac allograft with proinflammatory cytokine inhibitor. J Heart Lung Transplant, 20(5): 583-589, 2001.
  • Levey DL, Udono H, Heike M and Srivastava PK. Identification of a tumor-associated contact-dependent activity which reversibly downregulates cytolytic function of CD8+ T cells. Cancer Immun, 1: 5, 2001.

1996~2000

  • Fujiwara K, Udono H, Kunisada T, Kawai A, Inoue H, Takigawa M, Namba M, Nakayama E. Electrophoretic and serologic characterization of 56 kDa antigen (M56) with autologus serum derived from a chondrosarcoma patient: a shared antigen of immuneresponses in cancer and autoimmune diseases. Electrophoresis, 20: 3335-3342, 1999.
  • Udono H, Suto R, Tamura Y, Matsutake T, Srivastava PK. Heat shock proteins in cancer immunotherapy. Gann Monograph on Cancer Res, 48: 201-209, 1999.
  • Kakeya H, Udono H, Maesaki S, Sasaki E, Kawamura S, Hossain MA, Yamamoto Y, Sawai T, Fukuda M, Mitsutake K, Miyazaki Y, Tomono K, Tashiro T, Nakayama E, Kohno S. Heat shock protein 70 (HSP70) as a major target of the antibody response in patients with pulumonary cryptococcosis. Clin Exp Immunol, 115: 485-490, 1999.
  • Ishii T, Udono H, Yamano T, Ohta H, Uenaka A, Ono T, Hizuta A, Tanaka N, Srivastava PK, Nakayama E. Isolation of MHC class I restricted tumorantigen peptide and its precursors associated with heat shock proteins-hsp70, hsp90 and gp96. J Immunol, 162: 1303-1309, 1999.
  • Takaki T, Hiraki A, Uenaka A, Gomi S, Itoh K, Udono H, Shibuya A, Tsuji T, Sekiguchi S, Nakayama E. Variable expression on lung cancer cell lines of HLA-A2-binding MAGE-3 peptide recognized by cytotoxic T lymphocytes. Int J Oncol, 12: 1103-1109, 1998.
  • Blachere N, Li Z, Chandawarkar RY, Suto R, Jaikaria NS, Basu S, Udono H, Srivastava PK. Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity. J Exp Med, 186: 1315-1322, 1997.
  • Kakeya H, Udono H, Ikuno N, Yamamoto Y, Mitsutake K, Miyazaki T, Tomono K, Koga H, Tashiro T, Nakayama E, Kohno S. A 77 kDa protein from Cryptococcus neoformans, a member of the heat shock protein 70 family, is a major antigen detected by sera of mice with pulmonary Cryptococcosis. Infect Immunity, 65: 1653-1658, 1997.

1991~1995

  • Srivastava PK and Udono H. Heat shock protein-peptide complexes in cancer immunotherapy. Curr Opin Immunol, 6: 728-732, 1994.
  • Udono H., and Srivastava P.K. Comparison of Tumor - specific immunogenicities of stress - induced proteins gp96, hsp90, and hsp70. J Immunol, 152: 5398-5403, 1994.
  • Udono H, Levey D and Srivastava PK. Cellular requirements for tumor - specific immunity elicited by heat shock proteins: Tumor rejection antigen gp96 primes CD8+ T cells in vivo. Proc Nat Acad Sci USA, 91: 3077-3081, 1994.
  • Srivastava PK, Udono H, Blachere NE, Li Z. Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics, 39: 93-98, 1994.
  • Blachere NE, Udono H, Janetzki S, Li Z, Heike M and Srivastava PK. Heat shock protein vaccines against cancer. J Immunotherapy, 14: 352-356, 1993.
  • Udono H and Srivastava PK. Heat shock protein 70-associated peptides elicit specific cancer immunity. J Exp Med, 178: 1391-1396, 1993.
  • Suto R, Udono H, Yamamoto A, Shiku H and Nakayama E. Effect of accessory cells on stimulation of Murine T cell leukemia with antibodies to the CD3/T cell antigen receptor complex. Cancer Sic, 84: 438-444, 1993.
  • Mieno M, Suto R, Obata Y, Udono H, Takahashi T, Shiku H and Nakayama E. CD4-CD8- T cell receptor ab T cells: Generation of an in vitro Major Histocompatibility Complex Class I specific cytotoxic T lymphocyte response and allogeneic Tumor rejection. J Exp Med, 174: 193-201, 1991.

~1990

  • Matsubayashi Y, Hirama T, Morioka A, Iwashiro M, Masuda T, Uchino H, Takeshita S, Yamagishi H, Udono H, Mieno M, Nakayama E, Shiku H and Kuribayashi K. Participation of a dominant cytotoxic T cell population defined by a monoclonal antibody in syngeneic anti-tumor responses. Eur J Immunol, 20: 2095-2103, 1990.
  • Sasaki T, Mieno M, Udono H, Yamaguchi K, Usui T, Hara K, Shiku H and Nakayama E. Roles of CD4+ and CD8+ cells and effect of administration of r-IFNγ in listerial infection. J Exp Med, 171: 1141-1154, 1990.
  • Mieno M, Udono H, Ikegami S, Tada N, Shiku H and Nakayama E. Blocking of cytotoxic T-cell function of MOLF/Ei mice by anti-Ly35.1 monoclonal antibody. Immunology, 68: 431-433, 1989.
  • Udono H, Kuribayashi K, Fujita T, Mieno M, Shiku H and Nakayama E. Proliferative response of cloned CTL line 10B-5 upon stimulation with soluble clonotypic monoclonal antibody and its blocking by anti-Lyt-2 antibody. Immunobiology, 178: 390-400, 1989.
  • Udono H, Mieno M, Shiku H and Nakayama E. The roles of CD8+ and CD4+ cells in tumor rejection. Jpn J Cancer Res, 80: 649-654, 1989.
  • Kuribayashi K, Tanaka C, Matsubayashi Y, Masuda T, Udono H, Abe M, Nakayama E and Shiku H. Anti-idiotypic antibodies against UV-induced tumor specific CTL clones: preparation in syngeneic combination. J Immunol, 141: 4074-4080, 1988.
このページのトップへ
Copyright (C) OKAYAMA UNIVERSITY Graduate School of Medicine,
Dentistry and Pharmaceutical Sciences All Rights Reserved.
連絡先/岡山大学大学院医歯薬学総合研究科 病態制御科学専攻 腫瘍制御学講座 免疫学分野
〒700-8558 岡山県岡山市北区鹿田町2丁目5番1号
TEL:086-235-7192 FAX:086-235-7193 E-mail:
URL:http://www.okayama-u.ac.jp/user/immuno/