主な論文

Tomoaki Mori, Jun Sasaki, Takuya Kanamori, Yasuhiro Aoyama, and Takashi Sera
"Hypoxia-specific upregulation of the endogenous human VEGF-A gene by hypoxia-driven expression of artificial transcription factor"
Biochem. Biophys. Res. Commun. 2009, 390, 845-848.
Tomoaki Mori, Ikuko Kagatsume, Kazuki Shinomiya, Yasuhiro Aoyama, and Takashi Sera
"Sandwiched zinc-finger nucleases harboring a single-chain FokI dimer as a DNA-cleavage domain"
Biochem. Biophys. Res. Commun. 2009, 390, 694-697.

Tomoaki Mori, Jun Sasaki, Yasuhiro Aoyama, and Takashi Sera
"Regulation of vascular endothelial growth factor gene under hypoxia by using artificial transcription factors"
Nucleic Acids Symposium Series 2009, 53, 289-290.
Yoshihiro Koshino-Kimura, Kosuke Takenaka, Fumiya Domoto, Masayoshi Ohashi, Toshihide Miyazaki, Yasuhiro Aoyama, and Takashi Sera
"Construction of plants resistant to TYLCV by using artificial zinc-finger proteins"
Nucleic Acids Symposium Series 2009, 53, 281-282.
Yusuke Mineta, Tomoyuki Okamoto, Kosuke Takenaka, Norio Doi, Yasuhiro Aoyama, and Takashi Sera
"Multiple-turnover cleavage of double-stranded DNA by sandwiched zinc-finger nuclease"
Nucleic Acids Symposium Series 2009, 53, 279-280.
Takashi Sera
"Zinc-finger-based artificial transcription factors and their applications"
Advanced Drug Delivery Review 2009, 61, 513-526.
Takashi Mino, Yasuhiro Aoyama, and Takashi Sera
"Efficient double-stranded DNA cleavage by artificial zinc-finger nucleases composed of one zinc-finger protein and a single-chain FokI dimer"
Journal of Biotechnology 2009, 140, 156-161.
Yusuke Mineta, Tomoyuki Okamoto, Kosuke Takenaka, Norio Doi, Yasuhiro Aoyama, and Takashi Sera
"Enhanced cleavage of double-stranded DNA by artificial zinc-finger nuclease sandwiched between two zinc-finger proteins"
Biochemistry 2008, 47, 12257-12259.
Yoshihiro Koshino-Kimura, Kosuke Takenaka, Fumiya Domoto, Yasuhiro Aoyama, and Takashi Sera
"Generation of plants resistant to tomato yellow leaf curl virus by using artificial zinc-finger proteins"
Nucleic Acids Symposium Series 2008, 52, 189-190.
Tomoaki Mori, Jun Sasaki, Yasuhiro Aoyama, and Takashi Sera
"Modulation of endogenous VEGF-A expression under hypoxia by using artificial transcription factors"
Nucleic Acids Symposium Series 2008, 52, 187-188.
Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, and Takashi Sera
"Inhibition of human papillomavirus replication by using artificial zinc-finger nucleases"
Nucleic Acids Symposium Series 2008, 52, 185-186.
Shinsuke Sando, Hiroki Masu, Chika Furutani and Yasuhiro Aoyama
"Enzymatic N-methylaminoacylation of tRNA using chemically misacylated AMP as a substrate"
Org. Biomol. Chem. 2008, 6, 2666-2668.
Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, and Takashi Sera
"Cell-permeable artificial zinc-finger proteins as potent antiviral drugs for human papillomaviruses"
Arch. Virol. 2008, 153, 1291-1298.
Tomoaki Mori, Yusuke Mineta, Yasuhiro Aoyama, and Takashi Sera
"Efficient secretion of the herpes simplex virus tegument protein VP22 from living mammalian cells"
Arch. Virol. 2008, 153, 1191-1195.
世良貴史
「ウイルスの増殖を防ぐ人工タンパク質を組み込んだ、ウイルス耐性植物の創出」
ブレインテクノニュース 2008年1月号、第125号、pp8-11.
世良貴史
「ウイルスの感染でも枯れない植物を作る」
農林水産技術研究ジャーナル1月号特集、「夢のある農林水産研究」 2008年1月号、第31巻、pp25-27.
Kosuke Takenaka, Yoshihiro Koshino-Kimura, Yasuhiro Aoyama, Takashi Sera
"Inhibition of tomato yellow leaf curl virus replication by artificial zinc-finger proteins"
Nucleic Acids Symposium Series 2007, 51, 429-430.
Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera
"Development of protein-based antiviral drugs for human papillomaviruses"
Nucleic Acids Symposium Series 2007, 51, 427-428.
Tomoaki Mori, Jun Sasaki, Yasuhiro Aoyama, Takashi Sera
"Modulation of endogenous VEGF-A expression by artificial transcription factors"
Nucleic Acids Symposium Series 2007, 51, 345-346.
Takashi Mino, Tomoaki Mori, Naoki Matsumoto, Yusuke Mineta, Tomoaki Okamoto, Yasuhiro Aoyama, Takashi Sera
Application of Artificial Zinc-Finger Proteins to Inhibition of DNA Replication of Human Papillomavirus
Nucleic Acids Symposium Series 2006, 50, 313-314.
Tomoaki Mori, Jun Sasaki, Yasuhiro Aoyama, Takashi Sera
Regulation of Cancer-Related Growth Factor Expression by Artificial Zinc-Finger Proteins
Nucleic Acids Symposium Series 2006, 50, 291-292.
Takashi Mino, Takeaki Hatono, Naoki Matsumoto, Tomoaki Mori, Yusuke Mineta, Yasuhiro Aoyama, and Takashi Sera
Inhibition of DNA Replication of Human Papillomavirus by Artificial Zinc Finger Proteins
J. Virol. 2006, 80, 5405-5412.
Matsui, K. Sando, S. Sera, T. Aoyama, Y. Sasaki, Y. Komatsu, T. Terashima, T. Kikuchi, JI.
Cerasome as an Infusible, Cell-Friendly, and Serum-Compatible Transfection Agent in a Viral Size
J. Am. Chem. Soc. 2006, 128, 3114-3115.
Sera, T.
Inhibition of virus DNA replication by artificial zinc finger proteins
J. Virol. 2005, 79, 2614-2619.
Tachikawa, K. Schrder, O. Frey, G. Briggs, S.P. Sera, T.
Regulation of the Endogenous VEGF-A Gene by Exogenous Designed Regulatory Proteins
Pro. Natl. Acad. Sci. USA 2004, 101, 15225－15230.
F. Osaki, T. Kanamori, S. Sando, T. Sera, Y. Aoyama
A Quantum Dot Conjugated Sugar Ball and Its Cellular Uptake
On the Size Effects of Endocytosis in the Subviral Region
J. Am. Chem. Soc. 2004, 126, 6520-6521.
N. Tomita, S. Sando, T. Sera, Y. Aoyama
Macrocyclic proteoglycan mimics
Potent inhibition of cell adhesion by a bundle of chondroitin sulfate chains assembled on the calix[4]resorcarene platform
Bioorg. Med. Chem. Lett. 2004, 14, 2087-2090.
G. Xia, L. Chen, T. Sera, F. Ming, P.G. Schultz, and F.E. Romesberg
Directed Evolution of Novel Polymerase Activities
Mutation of a DNA Polymerase into an Efficient RNA Polymerase
Pro. Natl. Acad. Sci. USA 2002, 99, 6597－6602.
T. Sera and C. Uranga
Rational design of artificial zinc-finger proteins using a nondegenerate recognition code table
Biochemistry 2002, 41, 7074-7081.