Publications in international journals

Sanuki T, Miyawaki T, Iijima T: A survey on the safety of anesthesia management provided by dental anesthesiologists in Japan: a 5-year survey by the Japanese dental society of anesthesiology: Clin Oral Investig, 27(9): 5475-5483, 2023.

Miyake K, Higuchi H, Miyake S, Nishioka Y, Fujimoto M, Kurita E, Kawase A, Wakasugi Y,Miyawaki T: Evaluation of sedation levels using SedLine during intravenous sedation for dental procedures: a case-series Study: Anesth Prog, 70(2): 85-87, 2023.

Nishioka Y, Miyake S, Hamaoka M, Miyake K, Fujimoto M, Higuchi H, Miyawaki T: Anesthetic management using remimazolam in a hemodialysis patient.Anesth Prog: 70(2): 65-69, 2023.

Kurata S, Sanuki T, Higuchi H, Miyawaki T, Watanabe S, Maeda S, Sato S, Pinkham M, Tatkov S, Ayuse T: The clinical advantage of nasal high-flow in respiratory management during procedural sedation: a scoping review on the application of nasal high-flow during dental procedures with sedation. Jpn Dent Sci Rev, 58: 179-182, 2022.

Higashi T, Murata N, Fujimoto M, Miyake S, Egusa M, Higuchi H, Maeda S, Miyawaki T: Capsaicin may improve swallowing impairment in patients with amyotrophic lateral sclerosis: a randomized controlled trial. Acta Med Okayama, 76(2): 179-186, 2022.

Hoshijima H, Higuchi H, Sato(boku) A, Shibuya M, Morimoto Y, Fujisawa T, Mizuta K. Patient satisfaction with deep versus light/moderate sadation for non-surgical procedures, Medicine(Baltimore), 100(36): e27176, 2021.

Higuchi H, Takaya-Ishida K, Miyake S, Fujimoto M, Nishioka Y, Maeda S, Miyawaki T: Comparison of oxygen saturation between nasal high-flow oxygen and conventional nasal cannula in obese patients undergoing dental procedures with deep sedation: a randomized crossover Trial. J Oral Maxillofac Surg. 79 (9): 1842-1850, 2021.

Fujimoto M, Higuchi H, Honda-Wakasugi Y, Miyake S, Nishioka Y, Yabuki-Kawase A, Maeda S, Miyawaki T: Dexmedetomidine inhibits LPS-induced inflammatory responses through peroxisome proliferator-activated receptor gamma (PPARγ) activation following binding to α 2 adrenoceptors. Eur J Pharmacol, 173733, 2021

Wei-Hua L, Vijesh JB, Higuchi H, Ikeda S, Sean PP, Ikeda A: Metabolic alterations caused by the mutation and overexpression of the Tmem135 gene. Experimental Biology and Medicine, 245: 1571-1583, 2020.

Maeda S, Higuchi H, Fujimoto M, Miyake S, Honda-Wakasugi Y, Miyawaki T: Assessing the effectiveness of combined analgesics for bilateral ramus osteotomies. Anesth Prog, 67 (3): 140-145, 2020.

Hayashi R, Maeda S, Hideki T, Higuchi H, Miyawaki T: Pulmonary Aspiration during induction of general anesthesia. Anesth Prog, 2020.

Kodama M, Higuchi H, Ishii-Maruhama M, Nakano M,Honda-Wakasugi Y, Maeda S,Miyawaki T: Multi-drug therapy for epilepsy influenced bispectral index after a bolus propofol administration without affecting propofol's pharmacokinetics: a prospective cohort study. Sci Rep, 10:1578, 2020.

Miyake S, Higuchi H, Honda-Wakasugi Y, Fujimoto M, Kawai H, Nagatsuka H, Maeda S, Miyawaki T: Locally injected ivabradine inhibits carrageenan-induced pain and inflammatory responses via hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. PLoS One, 14: e0217209, 2019.

Tajiri A, Higuchi H, Miyawaki T: Hyperoxia reduces salivary secretion by inducing oxidative stress in mice. Arch Oral Biol, 98: 38-46, 2019.

Ishii-Maruhama M, Higuchi H, Nakanou M, Honda-Wakasugi Y, Yabuki-Kawase A, Maeda S, Miyawaki T:In vitro changes in the proportion of protein-unbound-free propofol induced by valproate. J Anesth, 32: 688-693, 2018.

Maeda S, Andoh T, Onishi R, Tomoyasu Y, Higuchi H, Miyawaki T: Remifentanil suppresses increase in interleukin-6 mRNA in the brain by inhibiting cyclic AMP synthesis. J Anesth, 32: 731-739, 2018.

Sarah Aileen L, Tetsuya T, Shima M, Hitoshi H, Anna-Lisa D, Giangela S, Nader S, Sakae I, Mahsa R, Akihiro I: The Effect of Tmem135 Overexpression on the Mouse Heart. PLoS One, 13: e0201986, 2018.

Higuchi H, Maeda S, Honda-Wakasugi Y, Yabuki-Kawase A, Miyawaki T: Intellectual disability is a risk factor for delayed emergence from total intravenous anaesthesia. J Intellect Disabil Res, 62: 217-224, 2017.

Takaya K, Higuchi H, Ishii-Maruhama M, Yabuki-Kawase A, Honda-Wakasugi Y, Tomoyasu Y, Maeda S, Miyawaki T: Capnography prevents hypoxia during sedation for dental treatment: A randomized controlled trial. JDR clin Ttrans Res, 2: 158-167, 2017.

Maeda S, Honda-Wakasugi Y, Tanimura H, Tomoyasu Y, Higuchi H, Murata N, Egusa M, Miyawaki T: Clinical analysis of analgesic and steroid use for extraction of teeth in patients with intellectual disability under general anesthesia. Open Dent J, 11: 181-186, 2017.

Watanabe Y, Higuchi H, Ishii-Maruhama M, Honda-Wakasugi Y, Yabuki-Kawase A, Yamane-Hirano A, Tomoyasu Y, Maeda S, Miyawaki T: Effect of a low dose of midazolam on high blood pressure in dental patients: a randomised, double-blind, placebo-controlled, two-centre study. Br J Oral Maxillofac Surg, 54: 443-448, 2016.

Hayashi T, Higuchi H, Tomoyasu Y, Ishii-Maruhama M, Maeda S, Miyawaki T: Effect of carbamazepine or phenytoin therapy on blood level of intravenously administered midazolam: a prospective cohort study. J Anesth, 30: 166-169, 2016.

Maeda S, Tomoyasu Y, Higuchi H, Honda Y, Ishii-Maruhama M, Miyawaki T: Female patients require a higher propofol infusion rate for sedation. Anesth Prog, 63: 67-70, 2016.

Wei-Hua L, Hitoshi H, Sakae I, Erica L M, Tetsuya T, Bikash R P, Che L, Li-Fang C, Sandra M S, Kathleen J K, C Dustin R, Robert F K, James A T, Robert F M, Joseph S T, Lawrence H P, Akihiro I: Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies. elife, 5: e19264, 2016.

Honda Y, Higuchi H, Matsuoka Y, Yabuki-Kawase A, Ishii-Maruhama M, Tomoyasu Y, Maeda S, Morimatsu H, Miyawaki T: The inhibitory effect of locally injected dexmedetomidine on carrageenan-induced nociception in rats. Eur J Pl4harmacol, 764: 215-219,2015.

Maeda S, Tomoyasu Y, Higuchi H, Ishii-Maruhama M, Egusa M, Miyawaki T: Independent predictors of delay in emergence from general anesthesia. Anesth Prog, 62: 8-13, 2015.

Maeda S, Tomoyasu Y, Higuchi H,Ishii-Maruhama M, Yamane A, Yabuki A, Honda Y, Egusa M, Miyawaki T: Independent factors affecting recovery time after sedation in patients with intellectual disabilities. Open Dent J, 31: 146-149, 2015.

Yamane A, Higuchi H, Tomoyasu Y, Ishii-Maruhama M, Maeda S, Miyawaki T: Effect of dexmedetomidine injected into the oral mucosa in combination with lidocaine on local anesthetic potency in humans: a crossover double-blind study. J Oral Maxillofac Surg, 73: 616-621, 2015.

Higuchi H, Yabuki A, Ishii-Maruhama M, Tomoyasu Y, Maeda S, Miyawaki T: Hemodynamic changes by drug interaction of adrenaline with chlorpromazine. Anesth Prog, 61: 150-154, 2014.

Tomoyasu Y,Higuchi H, Mori M, Takaya K, Honda Y, Yamane A, Yabuki A, Hayashi T, Ishii-Maruhama M, Jinzenji A, Maeda S, Kohjitani A, Shimada M, Miyawaki T: Chronic orofacial pain in dental patients - Retrospective investigation over 12 years-. Acta Medica Okayama, 68: 269-275, 2014.

Jinzenji A, Sogawa C, Miyawaki T, Wen XF, Yi D, Ohyama K, Kitayama S, Sogawa N, Morita K: Antiallodynic action of 1-(3-(9H-Carbazol-9-yl)-1-propyl)-4-(2-methyoxyphenyl)-4-piperidinol(NNC05-2090), a betaine/GABA transporter inhibitor. J Pharmacol Sci, 125: 217-226, 2014.

Yabuki A, Higuchi H, Yoshitomi T, Tomoyasu Y, Ishii-Maruhama M, Maeda S, Miyawaki T: Locally injected dexmedetomidine induces vasoconstriction via peripheral α-2A adrenoceptor subtype in Guinea pigs. Reg Anesth Pain Med, 39: 133-136, 2014.

Sukegawa S, Higuchi H, Inoue M, Nagatsuka H, Maeda S, Miyawaki T: Locally injected dexmedetomidine inhibits carrageenin-induced inflammatory responces in the injected region. Anesth Analg, 118: 473-480, 2014.

Kohjitani A, Miyawaki T, Nakamura N, Iwase Y, Ohno S, Shimada M, Sugiyama K: Features of lateral cephalograms associated with difficult laryngoscopy in Japanese children undergoing oral and maxillofacial surgery. Paediatr Anaesth, 23: 994-1001, 2013.

Numoto Y, Mori T, Maeda S, Tomoyasu Y, Higuchi H, Egusa M, Miyawaki T: Low bone mass is a risk factor in periodontal disease-related tooth loss in patients with intellectual disability. Open Dent J, 7: 157-161, 2013.

Numoto Y, Mori T, Maeda S, Tomoyasu Y, Higuchi H, Egusa M, Miyawaki T: Low bone mass is a risk factor in periodontal disease-related tooth loss in patients with intellectual disability. Open Dent J, 7: 157-161, 2013.

Maeda S, Suda M, Ishii M, Tomoyasu Y, Higuchi H, Okazaki Y, Egusa M, Miyawaki T: Extreme tooth abnormalities and treatment under general anesthesia in a child with chronic GVHD surving relapse of acute lymphoblastic leukemia. J Clin Pediatr Dent, 37: 199-201, 2012.

Maeda S, Tomoyasu Y, Higuchi H, Mori T, Egusa M, Miyawaki T: Midazolam is associated with delay in recovery and agitation after ambulatory general anesthesia for dental treatment in patients with disabilities: A retrospective cohort study. J Oral Maxiillofac Surg, 70: 1315-1320, 2012.

Arai Y, Maeda S, Higuchi H, Tomoyasu Y, Shimada M, Miyawaki T: Effects of midazolam and phenobarbital on brain oxidative reactions induced by pentylenetetrazole in a convulsion model. Immunopharmacol Immunotoxicol, 34: 216-221, 2012.

Miyawaki T, Kohjitani A, Maeda S, Higuchi H, Arai Y, Tomoyasu Y, Shimada M: Combination of midazolam and a cyclooxygenase-2 inhibitor inhibits lipopolysaccharide-induced interleukin-6 production in human peripheral blood mononuclear cells. Immunopharmacol Immunotoxicol, 34: 79-83, 2012. 

Ishii M, Higuchi H, Maeda S, Tomoyasu Y, Egusa M, Miyawaki T: The influence of oral VPA on the required dose of propofol for sedation during dental treatment in patients with mental retardation: a prospective observer-blinded cohort study. Epilepsia, 53: e13-16, 2012. 

Sakaguchi M, Higuchi H, Maeda S, Miyawaki T: Dental sedation for patients with intellectual disability: a prospective study of manual control versus bispectral index-guided target-controlled infusion of propofol. J Clin Anesth, 23: 636-642, 2011. 

Tomoyasu Y, Mukae K, Suda M, Hayashi T, Ishii M, Sakaguchi M, Watanabe Y, Jinzenji A, Arai Y, Higuchi H, Maeda S, Miyawaki T: Allergic reactions to local anesthetics in dental patients: analysis of intracutaneous and challenge tests. Open Dent J, 5: 146-149, 2011.

Ohmori J, Maeda S, Higuchi H, Ishii M, Arai Y, Tomoyasu Y, Kohjitani A, Shimada M, Miyawaki T: Propofol increases the rate of albumin-unbound free midazolam in serum albumin solution, J Anesth, 25: 618-620, 2011. 

Maeda S, Arai Y, Higuchi H, Tomoyasu Y, Mizuno R, Takahashi T, Miyawaki T: Induction of apoptotic change in the rat hippocampus caused by ferric nitrilotriacetate. Redox Report, 16: 114-120, 2011.

Tomoyasu Y, Yasuda T, Maeda S, Higuchi H, Miyawaki T: Liposome-encapsulated midazolam for oral administration. J Liposome Res, 21: 166-172, 2011.

Jinzenji A, Maeda S, Higuchi H, Yoshida K, Mori T, Egusa M, Miyawaki T: Partial laryngospasms during general anesthesia with a laryngeal mask airway for dental treatment: a report of 5 cases. J Oral Maxillofac Surg, 24: 146-147, 2010.

Higuchi H, Ishii M, Nakatsuka H, Maeda S, Morita K, Miyawaki T: Sudden cardiac arrest in head and neck surgery: a case report. J Anesth, 24: 146-147, 2010.

Xu X, Kedlaya R, Higuchi H, Ikeda S, Justice MJ, Setaluri V, Ikeda A: Mutation in archain1,a subunit of COPI coatomer complex, causes diluted coat color and Purkinje cell degeneration. PLoS Genet.20;6(5):e1,2010

 Nakatsuka I, Maeda S, Andoh T, Hayashi Y, Mizuno R, Higuchi H, Miyawaki T: Oxidative changes in the rat brain by intraperitoneal injection of ferric nitrilotriacetate. Redox Rep, 14: 109-114, 2009.

Kohjitani A, Higuchi H, Shimada M, Miyawaki T: Oral midazolam for sedation in minor oral operations in children: a retrospective Study. Br J Oral Maxillofac Surg, 46: 330-331, 2008.

Kohjitani A, Egusa M, Shimada M, Miyawaki T: Accumulated oropharyngeal water increases coughing during dental treatment with intravenous sedation. J Oral Rehabil, 35: 203-208, 2008.

 Maeda S, Miyawaki T, Higuchi H, Shimada M: Effect of flumazenil on disturbance of equilibrium function induced by midazolam. Anesth Prog, 55: 73-77, 2008.

 Yoshitomi T, Kohjitani A, Maeda S, Higuchi H, Shimada M, Miyawaki T: Dexmedetomidine enhances the local anesthetic action of lidocaine via an alpha-2A adrenoceptor. Anesth Analg, 107: 96-101, 2008.

 Umeda K, Takahashi T, Inoue K, Shimizu H, Maeda S, Morimatsu H, Omori E, Akagi R, Katayama H, Morita K: Prevention of hemorrhagic shock-induced intestinal tissue injury by glutamine via heme oxygenase-1 inudction. Shock: Epub ahead of print, 2008.

 Maeda S, Nakatsuka I, Hayashi Y, Higuchi H, Shimada M, Miyawaki T: Heme oxygenase-1 induction in the brain during lipopolysaccharide-induced acute inflammation. Neuropsychiatr Dis Treat, 4: 663-667, 2008.

 Higuchi H, Maeda S, Miyawaki T, Kohjitani A, Mori T, Ishida R, Egusa M, Shimada M: Dental management of a patient with takotsubo cardiomyopathy: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 103: e26-e29, 2007.

Mori T, Takeda N, Morita K, Kita F, Kajiwara K, Arioka K, Ishida R, Egusa M: Study on the longevity of dental restorations in patients with disabilities. dentistry in Japan, 43: 162-165, 2007.

 Kohjitani A, Funahashi M, Miyawaki T, Hanazaki M, Matsuo R, Shimada M: Peripheral N-methyl-D-aspartate receptors modulate nonadrenergic noncholinergic lower esophageal sphincter relaxation in rabbits. Anesth Analg, 101: 1681-1688, 2005.

 Maeda S, Nakatsuka I, Miyawaki T, Kuboki T, Shimada M: Stress induces changes of internal standard genes of amygdala. Mol Brain Res, 140: 133-137, 2005.

 Maeda S, Kita F, Miyawaki T, Takeuchi K, Ishida R, Egusa M, Shimada M: Assessment of patients with intellectual disability using the international classification of functioning, disability and health to evaluate dental treatment tolerability. J Intellect Disabil Res, 49: 253-259, 2005.

 Miyawaki T, Kohjitani A, Maeda S, Egusa M, Mori T, Higuchi H, Kita F, Shimada M: Intravenous sedation for dental patients with intellectual disability. J Intellect Disabil Res, 48: 764-768, 2004.

 Miyawaki T, Kohjitani A, Maeda S, Higuchi H, Shimada M: Effects of isoflurane-induced and prostaglandin E1-induced hypotension on cytokine responses to oral and maxillofacial surgery. J Clin Anesth, 16: 168-172, 2004.

 Miyawaki T, Nishimura f, Kohjitani A, Maeda S, Higuchi H, Kita F, Shimada M: Prevalence of blood pressure levels and hypertension-related diseases in Japan dental patients. Community Dent Health, 21: 134-137, 2004.

 Shimada M, Miyawaki T, Takeda K, Misaki T, Oka S, Yoshimura S, Ayuse T, Oi K, Seo K, Someya G, Ichinohe T, Kaneko Y, Ichihara K, Ito H, Umino M: Clinical usefulness 3% mepivacaine hydrochloride (scandonest) in infiltration anesthesia and block anesthesia. Dentistry in Japan, 40: 129-131, 2004.

 Miyawaki T, Kohjitani A, Maeda S, Kita F, Higuchi H, Shimada M: Serum cortisol level and depth of propofol-induced sedation. Acta Anaesthesiol Scand, 48: 384-385, 2004.

 Maeda S, Miyawaki T, Nomura S, Yagi T, Shimada M: Management of oral surgery in patients with hereditary or acquired angioedemas: review and case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 96: 540-543, 2003.

 Shimada M, Miyawaki T, Takeda K, Misaki T, Oka S, Yoshimura S, Ayuse T, Oi K, Seo K, Someya G, Ichinohe T, Kaneko Y, Ichihara K, Ito H, Umino M: The clinical anesthetic efficacy of 3% mepivacaine in infiltration and block anesthesia: a comparative double blind study with 2% lidocaine hydrochloride containing 1:80,000 epinephrine. Anesth Prog, 50: 88-90, 2003.

 Higuchi H, Funahashi M, Miyawaki T, Mitoh Y, Kohjitani A, Shimada M, Matsuo R: Suppression of the hyperpolarization-activated inward current contributes to the inhibitory actions of propofol on rat CAI and CA3 pyramidal neurons. Neurosci Res, 45: 459-472, 2003.

 Kohjitani A, Miyawaki T, Funahashi M, Mitoh Y, Matsuo R, Shimada M: Mexiletine inhibits nonadrenergic noncholinergic lower oesophageal sphincter relaxation in rabbits. Eur J Pharmacol, 465: 145-151, 2003.

 Kohjitani A, Miyawaki T, Funahashi M, Higuchi H, Matsuo R, Shimada M: Ketamine and midazolam differentially inhibit nonadrenergic noncholinergic lower esophageal sphincter relaxation in rabbits: role of superoxide anion and nitric oxide synthase. Anesthesiology, 98: 449-458, 2003.

 Kohjitani A, Miyawaki T, Kasuya K, Shimada M: Sympathetic activity-mediated neuropathic facial pain following simple tooth extraction: a case report. Cranio: The Journal of Craniomandibular Practice, 20: 135-138, 2002.

 Kohjitani A, Miyawaki T, Kasuya K, Mishima K, Sugahara T, Shimada M: Anesthetic management for advanced rheumatoid arthritis patients with acquired micrognathia undergoing temporomandibular joint replacement. J Oral Maxillofac Surg, 60: 559-566, 2002.

 Miyawaki T, Sogawa N, Maeda S, Kohjitani A, Shimada M: Effect of midazolam on interleukin-6 mRNA expression in human peripheral blood mononuclear cells in the absence of lipopolysaccharide. Cytokine, 15: 320-327, 2001.

 Funahashi M, Higuchi H, Miyawaki T, Shimada M, Matsuo R; Propofol suppresses a hyperpolarization-activated inward current in rat hippocampal CA1 neurons. Neurosci Lett, 311: 177-180, 2001.

 Kohjitani A, Miyawaki T, Funahashi M, Mitoh Y, Matsuo R, Shimada M: Intravenous anesthetics inhibit nonadrenergic noncholinergic lower esophageal sphincter relaxation via nitric oxide-cyclic guanosine monophosphate pathway modulation in rabbits. Anesthesiology, 95: 176-183, 2001.

 Maeda S, Miyawaki T, Kuboki T, Shimada M: A trigeminal neuralgia-like paroxysmal pain condition presumably due to buccal nerve compression in the temporalis muscle. The Journal of Craniomandibular Practice, 19: 56-60, 2001.

 Maekawa K, Kuboki T, Miyawaki T, Shimada M, Yamashita A, Glenn T Clark: Effect of intravenous infusion of an β-adrenergic blocking agent on the haemodynamic changes in human masseter muscle induced by cold pressor stimulation. Arch Oral Biol, 44: 475-483, 1999.

 Maekawa K, Kuboki T, Miyawaki T, Shimada M, Yamashita A, Glenn T Clark: Effect of intravenous infusion of an α-adrenergic blocking agent on the haemodynamic changes in human masseter muscle induced by cold pressor stimulation. Arch Oral Biol, 44: 319-327, 1999.

 Maeda S, Miyawaki T, Nakanishi T, Takigawa M, Shimada M: Peripheral type benzodiazepine receptor in T lymphocyte rich preparation. Life Sciences, 63: 1423-1430, 1998.

 Miyawaki T, Maeda S, Koyama Y, Fukuoka R, Shimada M: Elevation of plasma interleukin-6 levels is involved in postoperative fever following major oral and maxillofacial surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 85: 146-152, 1998.

 Miyawaki T, Maeda S, Shimada M: Elevation of plasma interleukin-6 level in patients undergoing oral and maxillofacial surgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 81: 15-20, 1996.

Presentation in the international meetings
<15th Annual meeting of Anesthesiology Societies>
Date: October 5-7, 2018
Place: Nara Kasugano International Forum IRAKA, Nara, Japan

Publish
１．Shigeru Maeda, Rieko Onishi, Yuka Honda-Wakasugi, Akiko Yabuki-Kawase, Hitoshi Higuchi, Takuya Miyawaki: Brain protection of dexmedetomidine in perioperative model. (2018. 10. 5)
２．Saki Miyake, Yuka Honda-Wakasugi, Akiko Yabuki-Kawase, Hitoshi Higuchi, Shigeru Maeda, Takuya Miyawaki： Ivabradine inhibits LPS-stimulated inflammatory cytokine production in the mouse macrophage-like cell line Raw264.7, but not via HCN-2 and HCN-4 channels. (2018. 10. 5)
３．Erika Kurita, Rieko Onishi, Hitoshi Higuchi, Yuka Honda-Wakasugi, Akiko Yabuki-Kawase, Shigeru Maeda,, Takuya Miyawaki: Management of a malignant pheochromocytoma patient undergoing oral surgery. (2018. 10. 6)
４．Maki Fujimoto, Yuka Honda-Wakasugi, Akiko Yabuki-Kawase, Hitosh Higuchi, Shigeru Maeda, Takuya Miyawaki: A muscle relaxant does not necessarily cause trismus in patients with masticatory muscle tendon-aponeurosis hyperplasia (2018. 10. 6)

<14th Annual meeting of Anesthesiology Societies>
Date: October 8-10, 2015
Place:InterContinental Hotel Berlin, Berlin, German

Publish
１．Honda Y, Onishi Y, Hitoshi H, Kodama M, Mori M, Takaya K, Suda M, Yabuki-Kawase A, Yamane-Hirano A, Ishii-Maruhama M, Tomoyasu Y, Maeda S, Miyawaki T, :The inhibitory effect of locally administered dexmedetomidine on acute inflammatory pain in rats. (2015.10.10)

<13th International Federation of Dental Anesthesiology Societies>
Date: February 29-March2,2012
Place:Fairmont Orchid, Kohala Coast, Hawaii, USA

Publish
１．Takuya Miyawaki, Yumiko Tomoyasu, Kazuo Mukae, Michiyo Suda, Tomoko Hayashi, Minako Isii, Yoshihisa Watanabe, Ayako Jinzenji, Yukiko Arai, Yuka Honda, Hitoshi Higuchi, Shigeru Maeda: Analysis of intracutaneous and challenge tests for allergic reactions to local anesthetics in dental patients. (2012. 3. 1)
２．Yukiko Arai, Shigeru Maeda, Hitoshi Higuchi, Yumiko Tomoyasu, Takuya Miyawaki: Effects of midazolam amd phenobarbital on brainoxidative reactions induced by pentylenetetrazole in a convulsion model. (2012. 3. 1)
３．Tomoko Hayashi, Shigeru Maeda, Hitoshi Higuchi, Yumiko Tomoyasu, Yukiko Arai,  Yoshihisa Watanabe, Ayako Jinzenji, Minako Isii, Kazuo Mukae, Michiyo Suda, Ayaka Yamane, Akiko Yabuki, Yuka Honda, Takuya Miyawaki: Cardiovascular management of patients with cardiomyopathy for oral surgery. (2012. 3. 1)
４．Kana Morimoto, Shigeru Maeda, Hitoshi Higuchi, Yumiko Tomoyasu, Yukiko Arai,  Yoshihisa Watanabe, Ayako Jinzenji, Minako Isii, Tomoko Hayashi, Kazuo Mukae, Michiyo Suda, Ayaka Yamane, Akiko Yabuki, Yuka Honda, Takuya Miyawaki: The observation of 10,348 patients receiving general anesthesia or sedation at the Department of Dental Anesthesiology in Okayama University Hospital (Japan) over the last 10 years. (2012. 3. 1)
５．Miho Inoue, Shintaro Sukegawa, Hitoshi Nagatsuka, Hitoshi Higuchi, Shigeru Maeda, Takuya Miyawaki: Dexmedetomidine is a possible candidate additive to dental local anesthetics to provide an anti-inflammatory potency against local acute inflammatory reactions. (2012. 3. 1)

<11th Annual meeting of Anesthesiology Societies>
Date: October4-7,2006
Place: Yokohama, Japan

Publish
１．Atsushi Kohjitani, Takuya Miyawaki, Shigeru Maeda, Hitoshi Higuchi, Keita Yoshida, Masahiko Shimada: Requirement of oral midazoram for sedation in pediatric patients undergoing minor oral and maxillofacial surgery:retrospective analysis in relevance to age. （2006. 10. 6）
２．Atsushi Kohjitani, Takuya Miyawaki, Shigeru Maeda, and Masahiko Shimada: Anesthetic Management for children with syndromes accompanying congenital anomalies undergoing oral and maxillofacial surgery. （2006. 10. 6）
３．Shigeru Maeda, Hitoshi Higuchi, Yoshihisa Watanabe, Yukiko Hayashi, Keita Yoshida, Atsushi Kohjitani, Masahiko Egusa, Takuya Miyawaki, and Masahiko Shimada: Clinical experience of general anesthesia using laryngeal mask airway for ambulatory dental treatment on patients with intellectual disability. （2006. 10. 6）

<97th General Session of International Association for Dental Reseach>
Date: June 19-22, 2019
Place: Vancouver, BC, Canada

Publish
１．Shigeru Maeda, Saki Miyake, Maki Fujimoto, Hitoshi Higuchi, Takuya Miyawaki: Dexmedetomidine Suppresses an increase in IL-6 mRNA in Models of Pperioperative Brain Ischemia. (2019. 7. 19)


<96th General Session of International Association for Dental Reseach>
Date: July 25-28, 2018
Place: ExCel London Convention Center, London, England

Publish
１．Shigeru Maeda, Akiko Yabuki-Kawase, Yuka Honda-Wakasugi, Saki Miyake, Yukiko Nishioka, Rieko Onishi, Maki Fujimoto, Erika Kurita, Hitoshi Higuchi, Takuya Miyawaki: Effective combinations of analgesics for ramus osteotomy. (2018. 7. 26)
２．Saki Miyake, Yuka Honda-Wakasugi, Akiko Yabuki-Kawase, Hitoshi Higuchi, Shigeru Maeda, Takuya Miyawaki : The inhibitory effect of locally administered ivabradine on inflammatory pain. (2018. 7. 26)
３．Yukiko Nishioka, Megumi Mori-Yoshioka, Hiroshi Tanimura, Yuka Honda-Wakasugi, Akiko Yabuki-Kawase, Hitoshi Higuchi, Shigeru Maeda, Takuya Miyawaki: Electrical surface charge and encapsulation efficiency of midazolam-encapsulating liposomes. (2018. 7. 26)


<95th General Session of International Association for Dental Reseach>
Date: March 22-25, 2017
Place: Moscone West Building, San Francisco, USA

Publish
１．Rieko Onishi, Shigeru Maeda, Akiko Yabuki-Kawase,Yuka Honda-Wakasugi, Hitoshi Higuchi, Takuya Miyawaki: The effect of continuous peripheral nerve block on neuropathic pain. (2017. 3. 23)
２．Hitoshi Higuchi, Yukiko Nishioka, Shigeru Maeda, Minako Ishii-Maruhama, Akiko Yabuki-Kawase, Yuka Honda-Wakasugi, Saki Miyake, Rieko Onishi, Megumi Mori-Yoshioka, Kumiko Takaya, Hiroshi Tanimura, Matsuri Kodama, Takuya Miyawaki: Oral midazolam for patients with intellectual disabilities. (2017. 3. 25)


<94th General Session of International Association for Dental Reseach>
Date: June 22-25, 2016
Place: COEX, Seoul, Republic of Korea

Publish
１．Hitoshi Higuchi, Minako Ishii-Maruhama, Yuka Honda-Wakasugi, Akiko Yabuki-Kawase, Shigeru Maeda, Takuya Miyawaki: The nasal high-flow system keeps obese individuals oxygenated during sedation. (2016.6.22)
２．Michiyo Suda, Hitoshi Higuchi, Yumiko Tomoyasu, Yuka Honda-Wakasugi, Saki Miyake, Rieko Onishi, Akiko Yabuki-Kawase, Minako Ishii-Maruhama, Megumi Mori-Yoshioka, Kumiko Takaya, Hiroshi Tanimura, Matsuri Kodama, Shigeru Maeda, Takuya Miyawaki: An approach to patients with orofacial pain using MMPI. (2016.6.24)


<93th General Session of International Association for Dental Reseach>
Date: March 11-14, 2015
Place: Hynes Convention Center, Boston, USA

Publish
１．Hitoshi Higuchi, Shigeru Maeda,　Minako Ishii-Maruhama, Akiko Yabuki, Ayaka Yamane, Yuka Honda, Yumiko Tomoyasu, Masahiko Egusa, Takuya Miyawaki: Intellectual disability associated with delayed recovery from total intravenous anesthesia. (2015. 3. 13)
２．Ayako Tajiri, Hitoshi Higuchi, Takuya Miyawaki: Influence of hyperoxia on salivary secretion in mice. (2015. 3. 12)
３．Yuka Honda, Hitoshi Higuchi, Minako Ishii-Maruhama, Yumiko Tomoyasu, Shigeru Maeda, Takuya Miyawaki: Additive effects of dexmedetomidine and indomethacin on acute inflammatory pain.(2015. 3. 13)
４．Megumi Mori, Hitoshi Higuchi, Minako Ishii-Maruhama, Yumiko Tomoyasu, Shigeru Maeda, Takuya Miyawaki: The development of liposome-encapsulated midazolam for oral sedation. (2015. 3. 13)
５．Kumiko Takaya, Hitoshi Higuchi, Akiko Yabuki, Minako Ishii-Maruhama, Yumiko Tomoyasu, Shigeru Maeda, Takuya Miyawaki: Effect of capnography on hypoxemia during deep sedation. （2015. 3. 13)


<92th General Session of International Association for Dental Reseach>
Date: June 25-28, 2014
Place: Cape Town, South Africa

Publish
１．Yumiko Tomoyasu, Hitoshi Higuchi, Yuka Honda, Ayaka Yamane, Akiko Yabuki, Shigeru Maeda, Yumiko Tomoyasu, Takuya Miyawaki: The clinical observation of dental patients with orofacial pain. (2014. 6. 25)


<91th General Session of International Association for Dental Reseach>
Date: March20-23,2013
Place: Seattle, Washington, USA

Publish
１．Hitoshi Higuchi, Akiko Yabuki, Shigeru Maeda, Yumiko Tomoyasu, Takuya Miyawaki: Drug interaction between adrenaline and chlorpromazine. (2013. 3. 21)
２．Ayaka Yamane, Akiko Yabuki, Yumiko Tomoyasu, Hitoshi Higuchi, Shigeru Maeda, Takuya Miyawaki: Locally injected dexmedetomidine enhances local anesthetic potency in humans. (2013. 3. 21)
３．Akiko Yabuki, Ayaka Yamane, Yumiko Tomoyasu, Hitoshi Higuchi, Shigeru Maeda, Takuya Miyawaki: Locally injected dexmedetomidine induces peripheral vasoconstriction via alpha-2 adrenoceptors. (2013. 3. 21)
４．Yoshihisa Watanabe, Yumiko Tomoyasu, Hitoshi Higuchi, Shigeru Maeda, Takuya Miyawaki: Effect of midazolam on blood pressure in hypertensive dental patients. （2013. 3. 21)


<90th General Session of International Association for Dental Reseach>
Date: June 20-23, 2012
Place: Iguazu, Brazil

Publish
１．Takuya Miyawaki: Local Anesthetics in Dentistry: New Insights into Old and New Drugs Symposium: Allergy and Safety of local Anesthetics. (2012. 6. 23)


<89th General Session of International Association for Dental Reseach>
Date: March 16-19, 2011
Place: San Diego, USA

Publish
１．Minako Ishii, Hitoshi Higuchi, Mai Sakaguchi, Tomoko Hayashi, Yukiko Arai, Yumiko Tomoyasu, Shigeru Maeda, Takuya Miyawaki: Intravenous sedation for patients with both intellectual disability and epilepsy．（2011. 3. 18)
２．Tomoko Hayashi, Hitoshi Higuchi, Minako Ishii, Yumiko Tomoyasu, Yukiko Arai, Shigeru Maeda, Takuya Miyawaki: Effect of antiepileptic drugs on pharmacokinetics of midazolam during aesthesia．（2011. 3. 18)
３．Yoko Numoto, Masahiko Egusa, Takayuki Mori,Takuya Miyawaki: Bone mass and tooth loss in patients with intellectual disability．（2011. 3. 18)


<88th General Session of International Association for Dental Reseach>
Date: July 14-17, 2010
Place: Barcelona, Spain

Publish
１．Mai Sakaguchi, Hitoshi Higuchi, Yumiko Tomoyasu, Shigeru Maeda, Takuya Miyawaki: Dental sedation for patients with intellectual diability．（2010. 7. 15)


<The 2012 American society of anesthsiologists annual meeting>
Date:October 13-17, 2012
Place: Washington DC, USA

Publish
１．Minako Ishii, Satoru Sakurai, Hitoshi Higuchi, Yumiko Tomoyasu, Sigeru Maeda, Takuya Miyawaki. Valproate increases the rate of protein-unbound free propofol in human serum. (2012. 10. 15)
２．Takuya Miyawaki, Shintaro Skegawa, Miho Inoue, Hitoshi Higuchi, Yumiko Tomoyasu, Minako Ishii, Shigeru Maeda. Locally injected dexmedetomidine inhibits carrageenin-induced TNF-alpha production in injected region. (2012. 10. 15)
３．Atsushi Kohjitani, Takuya Miyawaki, Shouichi Miyawaki, Norifumi Nakamura, Kazuhide Nishihara, Sachi Ohno, Masahiko Shimada, Kazuna Sugiyama. Use of lateral cephalograms to predict difficult intubation in japanese pediatric patients with craniofacial anomalies. (2012. 10. 13)


<The 2011 American society of anesthsiologists annual meeting>
Date: October 15-19, 2011
Place: Chicago, USA

Publish
１．Sintarou Sukegawa, Inoue M, Hitoshi Higuchi, Yumiko Tomoyasu, Sigeru Maeda, Takuya Miyawaki. Loccally injected dexmedetomidine inhibits carrageenin-induced inflammatory reaction in injected region. (2011. 10. 19)


<The 2008 American society of anesthsiologists annual meeting>
Date: October 18-22, 2008
Place: Florida, USA

Publish
１．Sakurai S, Fukunaga AF, Miyawaki T, Ichinohe T, Kaneko Y. Role of adenosine in midazolam-induced sedative/hypnotic effects in human volunteers. (2008. 10. 22)


<Neuroscience 2011: Society for Neuroscience, 41th Annual Meeting>
Date:November 12-16, 2011
Place: Washington, D.C, USA

Publish
1.Tomoyasu Y, Maeda S , Higuchi H, Suda M, Ishii M, Miyawaki T: Effect of remifentanil against septic shock model. (2011. 11. 14)

<Neuroscience 2008: Society for Neuroscience, 38th Annual Meeting>
Date: November 15-19, 2008
Place: Washington, D.C, USA

Publish
１．Maeda S, Hayashi Y, Mizuno R, Higuchi H, Miyawaki T: Brain reactions to continuous intracerebroventricular injeciton of ferric nitrilotriacetate (Fe-NTA).
2．Higuchi H, Maeda S, Takahashi T, Hayashi Y, Miyawaki T. Hemorrhagic shock followed by resuscitation induces heme oxyganase-1 mRNA in rat brain.

<Neuroscience 2007: Society for Neuroscience, 37th Annual Meeting>
Date: November 3-7, 2007
Place: Calfornia, USA

Publish
１．Maeda S, Hayashi Y, Higuchi H, Miyawaki T: Brain oxidative reactions to continuous intracerebroventricular (icv) infusion of ferric nitrilotriacetate (Fe-NTA).


<Neuroscience 2006: Society for Neuroscience, 36th Annual Meeting>
Date: October 14-18, 2006
Place: Georgia, USA

Publish
１．Maeda S, Nakatsuka I, Andoh T, Yamaai Y, Higuchi H, Miyawaki T, Shimada M: Brain reactions to oxidative stress caused by intraperitoneal injection of ferric nitrirotriacetate (Fe-NTA) in rats.

Publications in Japanese journals　

Suda M, Yoshida K, Yamane A, Ishii M, Watanabe Y, Maeda S, Miyawaki T: General anesthesia for a dental patient with Dandy-Walker syndrome. J Jpn Dent Soc Anesthesiol, 39: 230-231, 2011.

Arai Y, Yamane A, Yabuki A, Mukae K, Suda M, Tomoyasu Y, Maeda S, Miyawaki T:Evaluation of perceptual paralysis at mental nerve appling with pain vision. J Jpn Dent Soc Anesthesiol, 39: 188-189, 2010.

Ishii M, Higuchi H, Jinzenji A, Hayashi T, Sakaguchi M, Arai Y, Watanabe Y, Tomoyasu Y, Yoshida K, Maeda S, Miyawaki T: Postoperative sedation with a combination of dexmedetomidine hydrochloride and propofol with patient-controlled sedation in patients undergoing oral and maxillofacial surgery. J Jpn Dent Soc Anesthesiol, 38: 279-283, 2010.

Takeuchi H, Jinzenji A, Yoshida K, Tomoyasu Y, Maeda S, Miyawaki T: A case of management with midazolam and remifentanil for preventing severe gagging reflex during dental treatment. J Jpn Dent Soc Anesthesiol, 38: 219-220, 2010.

Hayashi T, Yoshida K, Jinzenji A, Higuchi H, Maeda S, Miyawaki T: General anesthesia for a patient with aspirin-induced asthma,diagnosed as dilated cardiomyopathy on a preoperative examination in oral surgery. J Jpn Dent Soc Anesthesiol, 38: 47-48, 2010.

Arai Y, Higuchi H, Ishii M, Maeda S, Miyawaki T: A case of complexity cyanotic congential heart disease managed with intravenous sedation using fentanyl for dental treatment. J Jpn Dent Soc Anesthesiol, 37: 293-294, 2009.

Sakaguchi M, Higuchi H, Yoshida K, Hayashi Y, Jinzenji A, Tomoyasu Y, Watanabe Y,  Yoshitomi T, Kita F, Maeda S, Miyawaki T: Anesthesia report of a patient with an epiglottic cyst found at the preoperative CT scan. J Jpn Dent Soc Anesthesiol, 36: 575-576, 2008. 

Jinzenji A, Maeda S, Higuchi H, Sakaguchi M, Watanabe Y, Hayashi Y, Tomoyasu Y, Yoshida K, Miyawaki T: Use of remifentanil on general anesthesia in combination with sevoflurane and propofol for oral and maxillofacial surgery. J Jpn Dent Soc Anesthesiol, 36: 49-50, 2008.

Higuchi H, Maeda S, Yoshida K, Hayashi Y, Tomoyasu Y, Sakaguchi M, Jinzenji A, Watanabe Y, Miyawaki T: The combination of sedation by dexmedetomidine hydrochloride and patient-controlled sedation by propofol in postoperative patients of oral and maxillofacial surgery. J Jpn Dent Soc Anesthesiol, 35 : 693-694, 2007.

Tomoyasu Y, Higuchi H, Yoshida K, Watanabe Y, Hayashi Y, Kohjitani A, Maeda S, Miyawaki T, Shimada M: A comparison between dexmedetomidine hydrochloride and propofol in sedation following oral and maxillofacial surgery. J Jpn Dent Soc Anesthesiol, 35: 197-201, 2007.

Watanabe Y, Yoshida K, Hayashi Y, Higuchi H, Kohjitani A, Maeda S, Miyawaki T, Shimada M: Anesthetic management of a myotonic dystrophy patient ,measuring CICR (Ca-induced Ca release) rate prior to general anesthesia. J Jpn Dent Soc Anesthesiol, 35: 70-71, 2007.

Nishi C, Yoshida K, Tomoyasu Y, Higuchi H, Kohjitani A, Maeda S, Miyawaki T, Shimada M: The influence of antiepileptic drugs on intravenous sedation with midazolam and propofol for dental treatment in patients with intellectual disabilities. J  Jpn Dent Soc Anesthesiol, 34: 169-172, 2006.

Yoshida K, Maeda S, Tomoyasu Y, Nishi C, Higuchi H, Kohjitani A, Miyawaki T, Shimada M: Analysis of autologous blood transfusion at the Okayama university medical and dental hospital. J Jpn Dent Soc Anesthesiol, 33: 433-438, 2005.

Yoshida K, Maeda S, Tomoyasu Y, Nishi C, Higuchi H, Kohjitani A, , Miyawaki T, Shimada M: Analysis of homologous blood transfusion at the Okayama university dental hospital (Okayama university medical and dental hospital). J Jpn Dent Soc Anesthesiol, 33: 234-238, 2005.

Nishi C, Miyawaki T, Yoshida K, Tomoyasu Y, Kita F, Kohjitani A, Maeda S, Yoshihama Y, Shimada M: A case of subclinical pulmonary embolism occurring after mandibular tumor resection and reconstruction with free grafts. J Jpn Dent Soc Anesthesiol, 32: 379-380, 2004.

Kita F, Miyawaki T, Kohjitani A, Maeda S, Higuchi H, Yoshida K, Shimada M: A report of damaged endotracheal tube during oral surgery. J Jpn Dent Soc Anesthesiol, 31: 39-40, 2003.

Shimada M, Miyawaki T, Takada K, Misaki T, Oka S, Yoshimura S, Ayuse T, Oi K, Seo K, Someya G, Ishinose T, Kaneko Y, Ichihara K, Ito H, Umino M: The clinical anesthetic Efficacy of 3 % mepivacaine in infiltration and block anesthesia : A comparative double blind study with 2％ lidocaine hydrochloride containing 1:80,000 epinephrine. J Jpn Dent Soc Anesthesiol, 30: 48-61, 2002.

Maeda S, Miyawaki T, Shimada M: The effect of flumazenil on sedation and disturbance of equilibrium function by midazolam : part 2. J Jpn Dent Soc Anesthesiol, 23: 111-118, 1995.

Maeda S, Shimada M, Miyawaki T, Koyama E, Nishijima K: The effect of flumazenil on sedation, amnesia, and disturbance of equilibrium function by diazepam Part 2. J Jpn Dent Soc Anesthesiol, 22: 28-35, 1994.

Maeda S, Shimada M, Miyawaki T, Koyama E, Nishijima K: The effect of flumazenil on sedation, amnesia, and disturbance of equilibrium function by diazepam. J Jpn Dent Soc Anesthesiol, 21: 407-416, 1993.

Miyawaki T, Yao H, Koyama E, Maeda S, Nishijima K, Sunami J, Takebayashi T, Ohyama K: Clinical study of controlled hypotension induced by prostaglandin E1 for maxillectomy. J Jpn Dent Soc Anesthesiol, 18: 672-678, 1990.

Yakaya Y, Nishijima K, Miyawaki T, Koyama H, Sunami J, Yao H: A comparative study between inhalation sedation with nitrous oxide and intravenous sedation with diazepam by questionnaire. J Jpn Dent Soc Anesthesiol, 18: 642-648,1990.

Miyawaki T, Yao H, Sunami J, Koyama E, Ogata K, Ueno T, Koyama S, Nishijima K: A case of management of respiratory failure during radiotherapy combined with chemotherapy for oral cancer. J Jpn Dent Soc Anesthesiol, 17: 310-316,1989. 

Miyawaki T, Yao H, Kobayashi H, Sunami J, Koyama E, Edo M, Ogata K, Takaya Y, Nishijima K, Kosaka F: Statistical observations on the cases of general anesthesia for oral surgery during a five-year period in okayama university dental hospital. J Jpn Dent Soc Anesthesiol, 16: 193-200,1988.