業績
論 文
2025
- Kuribayashi T, Kinoshita R, Ninomiya K, Makimoto G, Kubo T, Rai K, Ichihara E, Hotta K, Tabata M, Maeda Y, Kiura K, Toyooka S, Sakaguchi M, Ohashi K.
Plasma S100A8/A9 level predicts response to immune checkpoint inhibitors in patients with advanced non-small cell lung cancer.
Sci Rep. 2025 Jan 20;15(1):2577. doi:10.1038/s41598-025-87232-z.
- Gohara Y, Kinoshita R, Tomonobu N, Jiang F, Matsunaga Y, Hashimoto Y, Honjo T, Yamamoto KI, Murata H, Ochi T, Komalasari NLGY, Yamauchi A, Kuribayashi F,Sakaguchi Y, Futami J, Inoue Y, Kondo E, Toyooka S, Morizane S, Ishiko A, Morita S, Sagayama K, Nakao K, Sakaguchi M.
An S100A8/A9 Neutralizing Antibody Potently Ameliorates Contact Hypersensitivity and Atopic Dermatitis Symptoms.
J Invest Dermatol. 2025 Jan 21:S0022-202X(25)00029-6. doi:10.1016/j.jid.2025.01.007.
- Ota Y, Gao T, Fujisawa M, Sumardika IW, Sakaguchi M, Toyooka S, Yoshimura T, Matsukawa A.
Expression of SPRED2 in the lung adenocarcinoma.
Pathol Res Pract. 2025 Jan;265:155721. doi: 10.1016/j.prp.2024.155721.
2024
- Wang Y, Moh-Moh-Aung A, Wang T, Fujisawa M, Ohara T, Yamamoto KI, Sakaguchi M, Yoshimura T, Matsukawa A. /br>
Exosomal delivery of miR-200b-3p suppresses the growth of hepatocellular carcinoma cells by targeting ERG- and VEGF-mediated angiogenesis.
Gene. 2024 Dec 30;931:148874. doi: 10.1016/j.gene.2024.148874.
- Furuya-Ikude C, Kitta A, Tomonobu N, Kawasaki Y, Sakaguchi M, Kondo E.
NCF-1 plays a pivotal role in the survival of adenocarcinoma cells of pancreatic and gastric origins.
In Vitro Cell Dev Biol Anim. 2024 Dec;60(10):1151-1159. doi:10.1007/s11626-024-00994-0.
- Sakaguchi M, Kinoshita R, Tomonobu N, Sakaguchi Y, Futami J, Yamauchi A, Murata H, Yamamoto KI, Takahashi T, Gohara Y, Ochi T, Jiang F, Komalasari NLGY, Chen Y, Ruma IMW, Sumardika IW, Zhou J, Honjo T, Kuribayashi F, Sagayama K, Toyooka S, Kondo E, Inoue Y.
Enhanced design of pCMViR-TSC plasmid vector for sustainably high cargo gene expression in mammalian cells.
In Vitro Cell Dev Biol Anim. 2024 Dec;60(10):1215-1227. doi: 10.1007/s11626-024-00992-2.
- Zhou J, Murata H, Tomonobu N, Mizuta N, Yamakawa A, Yamamoto KI, Kinoshita R, Sakaguchi M.
S100A11 is involved in the progression of colorectal cancer through the desmosome-catenin-TCF signaling pathway.
In Vitro Cell Dev Biol Anim. 2024 Dec;60(10):1138-1149. doi: 10.1007/s11626-024-00930-2.
- Zhou J, Murata H, Tomonobu N, Mizuta N, Yamakawa A, Yamamoto KI, Kinoshita R, Sakaguchi M.
Correction: S100A11 is involved in the progression of colorectal cancer through the desmosome-catenin-TCF signaling pathway.
In Vitro Cell Dev Biol Anim. 2024 Jun 27. doi: 10.1007/s11626-024-00940-0.
- Wang T, Gao T, Fujisawa M, Ohara T, Sakaguchi M, Yoshimura T, Matsukawa A.
SPRED2 Is a Novel Regulator of Autophagy in Hepatocellular Carcinoma Cells and Normal Hepatocytes.
Int J Mol Sci. 2024 Jun 6;25(11):6269. doi:10.3390/ijms25116269.
- Jiang F, Chen Y, Tomonobu N, Kinoshita R, Komalasari NLGY, Kasano-Camones CI, Ninomiya K, Murata H, Yamamoto KI, Gohara Y, Ochi T, Ruma IMW, Sumardika IW, Zhou J, Honjo T, Sakaguchi Y, Yamauchi A, Kuribayashi F, Futami J, Kondo E, Inoue Y, Toyooka S, Sakaguchi M.
Dissection of the signal transduction machinery responsible for the lysyl oxidase-like 4-mediated increase in invasive motility in triple-negative breast cancer cells: mechanistic insight into the integrin-β1-NF-κB-MMP9 axis.
Front Oncol. 2024 May 28;14:1371307. doi:10.3389/fonc.2024.1371307.
- Takahashi T, Tomonobu N, Kinoshita R, Yamamoto KI, Murata H, Komalasari NLGY, Chen Y, Jiang F, Gohara Y, Ochi T, Ruma IMW, Sumardika IW, Zhou J, Honjo T, Sakaguchi Y, Yamauchi A, Kuribayashi F, Kondo E, Inoue Y, Futami J, Toyooka S, Zamami Y, Sakaguchi M.
Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface.
Front Oncol. 2024 Mar 26;14:1371342. doi: 10.3389/fonc.2024.1371342.
- Mitsui A, Iioka H, Ling Y, Okuda S, Kurose A, Schopperle M, Kondo T,Sakaguchi M, Saito K, Kondo E.
Pathological and Biological Significance of the Specific Glycan, TRA-1-60, on Aggressive Gastric Adenocarcinoma.
Lab Invest. 2024 May 6;104(7):102073. doi: 10.1016/j.labin
- Takihira S, Yamada D, Osone T, Takao T, Sakaguchi M, Hakozaki M, Itano T, Nakata E, Fujiwara T, Kunisada T, Ozaki T, Takarada T.
PRRX1-TOP2A interaction is a malignancy-promoting factor in human malignant peripheral nerve sheath tumours.
Br J Cancer. 2024 Mar 6. doi: 10.1038/s41416-024-02632-8.
- Takatsu F, Suzawa K, Tomida S, Thu YM, Sakaguchi M, Toji T, Ohki M, Tsudaka S, Date K, Matsuda N, Iwata K, Zhu Y, Nakata K, Shien K, Yamamoto H, Nakayama A, Okazaki M, Sugimoto S, Toyooka S.
Correction to: Periostin secreted by cancer‑associated fibroblasts promotes cancer progression and drug resistance in non‑small cell lung cancer.
J Mol Med (Berl). 2024 Jan;102(1):147. doi:10.1007/s00109-023-02408-2.
2023
- Ni Luh Gede Yoni Komalasari, Nahoko Tomonobu, Rie Kinoshita, Youyi Chen, Yoshihiko Sakaguch, Yuma Gohara, Fan Jiang, Ken-ich Yamamoto, Hitoshi Murata, I Made Winarsa Ruma, I Wayan Sumardika, Jin Zhou, Akira Yamauchi, Futoshi Kuribayashi, Yusuke Inoue, Shinichi Toyooka and Masakiyo Sakaguchi.
Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that is dependent on the enzymatic activity that targets the cell-surface annexin A2.
Frontiers in Oncology. 2023 Apr 4. doi:.10.3389/fonc.2023.1142907.
- Gao T, Yang X, Fujisawa M, Ohara T, Wang T, Tomonobu N, Sakaguchi M, Yoshimura T, Matsukawa A.
SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells.
Int J Mol Sci. 2023 Mar 5;24(5):4996. doi: 10.3390/ijms24054996.
- Gohara Y, Tomonobu N, Kinoshita R, Futami J, Audebert L, Chen Y, Komalasari NLGY, Jiang F, Yoshizawa C, Murata H, Yamamoto KI, Watanabe M, Kumon H, Sakaguchi M.
Novel extracellular role of REIC/Dkk-3 protein in PD-L1 regulation in cancer cells.
J Mol Med (Berl). 2023 Mar 4. doi: 10.1007/s00109-023-02292-w.
- Hirabayashi D, Yamamoto KI, Maruyama A, Tomonobu N, Kinoshita R, Chen Y, Komalasari NLGY, Murata H, Gohara Y, Jiang F, Zhou J, Ruma IMW, Sumardika IW, Yamauchi A, Kuribayashi F, Toyooka S, Inoue Y, Sakaguchi M.
LOXL1 and LOXL4 are novel target genes of the Zn2+-bound form of ZEB1 and play a crucial role in the acceleration of invasive events in triple-negative breast cancer cells.
Front Oncol. 2023 Feb 23;13:1142886. doi: 10.3389/fonc.2023.1142886.
- Kasano-Camones CI, Takizawa M, Ohshima N, Saito C, Iwasaki W, Nakagawa Y, Fujitani Y, Yoshida R, Saito Y, Izumi T, Terawaki SI, Sakaguchi M, Gonzalez FJ, Inoue Y.
PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice.
J Biochem. 2023 Apr 26;173(5):393-411. doi: 10.1093/jb/mvad005.
2022
- Xue R, Lin W, Fujita H, Sun J, Kinoshita R, Ochiai K, Futami J, Watanabe M,Ohuchi H, Sakaguchi M, Tang Z, Huang P, Nasu Y, Kumon H.
Dkk3/REIC Deficiency Impairs Spermiation, Sperm Fibrous Sheath Integrity and the Sperm Motility of Mice.
Genes (Basel). 2022 Jan 31;13(2):285. doi: 10.3390/genes13020285.
- Tomonobu N, Kinoshita R, Wake H, Inoue Y, Ruma IMW, Suzawa K, Gohara Y, Komalasari NLGY, Jiang F, Murata H, Yamamoto KI, Sumardika IW, Chen Y, Futami J, Yamauchi A, Kuribayashi F, Kondo E, Toyooka S, Nishibori M, Sakaguchi M.
Histidine-Rich Glycoprotein Suppresses the S100A8/A9-Mediated Organotropic Metastasis of Melanoma Cells.
Int J Mol Sci. 2022 Sep 7;23(18):10300. doi:10.3390/ijms231810300.
- Li C, Yoshimura T, Tian M, Wang Y, Kondo T, Yamamoto KI, Fujisawa M, Ohara T, Sakaguchi M, Matsukawa A. Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer.
Breast Cancer Res. 2022 Sep 12;24(1):60. doi: 10.1186/s13058-022-01557-5.
- Nakata K, Okazaki M, Sakaue T, Kinoshita R, Komoda Y, Shimizu D, Yamamoto H, Tanaka S, Suzawa K, Shien K, Miyoshi K, Yamamoto H, Ohara T, Sugimoto S, Yamane M, Matsukawa A, Sakaguchi M, Toyooka S.
Functional Blockage of S100A8/A9 Ameliorates Ischemia-Reperfusion Injury in the Lung.
Bioengineering (Basel).2022 Nov 10;9(11):673. doi:10.3390/bioengineering9110673.
- Shimizu D, Okazaki M, Sugimoto S, Kinoshita R, Nakata K, Tanaka S, Hashimoto K, Miyoshi K, Yamane M, Matsukawa A, Sakaguchi M, Toyooka S.
Inhibiting S100A8/A9 attenuates airway obstruction in a mouse model of heterotopic tracheal transplantation.
Biochem Biophys Res Commun. 2022 Nov 12;629:86-94. doi:10.1016/j.bbrc.2022.08.087.
- Okamoto S, Miyano K, Choshi T, Sugisawa N, Nishiyama T, Kotouge R, Yamamura M, Sakaguchi M, Kinoshita R, Tomonobu N, Katase N, Sasaki K, Nishina S, Hino K, Kurose K, Oka M, Kubota H, Ueno T, Hirai T, Fujiwara H, Kawai C, Itadani M, Morihara A, Matsushima K, Kanegasaki S, Hoffman RM, Yamauchi A, Kuribayashi F.
Inhibition of pancreatic cancer-cell growth and metastasis in vivo by a pyrazole compound characterized as a cell-migration inhibitor by an in vitro chemotaxis assay.
Biomed Pharmacother. 2022 Nov;155:113733. doi:10.1016/j.biopha.2022.113733.
- Herik Rodrigo AG, Tomonobu N, Yoneda H, Kinoshita R, Mitsui Y, Sadahira T, Terawaki SI, Gohara Y, Gede Yoni Komalasari NL, Jiang F, Murata H, Yamamoto KI, Futami J, Yamauchi A, Kuribayashi F, Inoue Y, Kondo E, Toyooka S, Nishibori M, Watanabe M, Nasu Y, Sakaguchi M.
Toll-like receptor 4 promotes bladder cancer progression upon S100A8/A9 binding, which requires TIRAP-mediated TPL2 activation.
Biochem Biophys Res Commun. 2022 Dec 17;634:83-91. doi:10.1016/j.bbrc.2022.09.116.
2021
- Tachibana K, Tang N, Urakami H, Kajita A, Kobashi M, Nomura H, Sasakura M, Sugihara S, Jiang F, Tomonobu N, Sakaguchi M, Ouchida M, Morizane S.
Multifaceted Analysis of IL-23A- and/or EBI3-Including Cytokines Produced by Psoriatic Keratinocytes.
Int J Mol Sci. 2021 Nov 23;22(23):12659. doi:10.3390/ijms222312659.
- Miura A, Yamada D, Nakamura M, Tomida S, Shimizu D, Jiang Y, Takao T, Yamamoto H, Suzawa K, Shien K, Yamane M, Sakaguchi M, Toyooka S, Takarada T.
Oncogenic potential of human pluripotent stem cell-derived lung organoids with HER2 overexpression.
Int J Cancer. 2021 Oct 15;149(8):1593-1604. doi:10.1002/ijc.33713.
- He F, Matsumoto Y, Asano Y, Yamamura Y, Katsuyama T, Rose J, Tomonobu N, Komalasari NLGY, Sakaguchi M, Rottapel R, Wada J.
RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion.
FrontOncol. 2021 Jul 20;11:729192. doi: 10.3389/fonc.2021.729192.
- Yamamoto K, Oshiki T, Kagawa H, Namba M, Sakaguchi M.
Presence of Microplastics in Four Types of Shellfish Purchased at Fish Markets in Okayama City, Japan.
Acta Med Okayama. 2021 Jun;75(3):381-384. doi: 10.18926/AMO/62234.
- Nakamura K, Akagi S, Ejiri K, Yoshida M, Miyoshi T, Sakaguchi M, Amioka N, Suastika LOS, Kondo M, Nakayama R, Takaya Y, Higashimoto Y, Fukami K, Matsubara H, Ito H.
Inhibitory effects of RAGE-aptamer on development of monocrotaline-induced pulmonary arterial hypertension in rats.
J Cardiol. 2021 Jul;78(1):12-16. doi: 10.1016/j.jjcc.2020.12.009.
- Saito K, Mitsui A, Sumardika IW, Yokoyama Y, Sakaguchi M, Kondo E.
PLOD2-driven IL-6/STAT3 signaling promotes the invasion and metastasis of oral
squamous cell carcinoma via activation of integrin β1.
Int J Oncol. 2021 Jun;58(6):29. doi: 10.3892/ijo.2021.5209.
- Takahashi Y, Wake H, Sakaguchi M, Yoshii Y, Teshigawara K, Wang D, Nishibori M.
Histidine-Rich Glycoprotein Stimulates Human Neutrophil Phagocytosis and Prolongs Survival through CLEC1A.
J Immunol. 2021 Feb 15;206(4):737-750. doi:10.4049/jimmunol.2000817.
- Araki K, Kinoshita R, Tomonobu N, Gohara Y, Tomida S, Takahashi Y, Senoo S, Taniguchi A, Itano J, Yamamoto KI, Murata H, Suzawa K, Shien K, Yamamoto H, Okazaki M, Sugimoto S, Ichimura K, Nishibori M, Miyahara N, Toyooka S, Sakaguchi M.
The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis.
J Mol Med (Berl). 2021 Jan;99(1):131-145. doi:10.1007/s00109-020-02001-x.
2020
- Nakamura K, Akagi S, Ejiri K, Yoshida M, Miyoshi T, Sakaguchi M, Amioka N,Suastika LOS, Kondo M, Nakayama R, Takaya Y, Higashimoto Y, Fukami K, Matsubara H, Ito H.
Inhibitory effects of RAGE-aptamer on development of monocrotaline-induced pulmonary arterial hypertension in rats.
J Cardiol. 2020 Dec 29:S0914-5087(20)30410-X. doi: 10.1016/j.jjcc.2020.12.009.
- Kota Araki, Rie Kinoshita, Nahoko Tomonobu, Yuma Gohara, Shuta Tomida, Yuta Takahashi,Satoru Senoo, Akihiko Taniguchi, Junko Itano, Ken-ichi Yamamoto, Hitoshi Murata, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Kouichi Ichimur, Masahiro Nishibori, Nobuaki Miyahara, Shinichi Toyooka, Masakiyo Sakaguchi.
The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis. Journal of Molecular Medicine.
2020 Nov 9. https://doi.org/10.1007/s00109-020-02001-x.
- Fatmawati NND, Gotoh K, Mayura IPB, Nocianitri KA, Suwardana GNR, Komalasari NLGY, Ramona Y, Sakaguchi M, Matsushita O, Sujaya IN.
Enhancement of intestinal epithelial barrier function by Weissella confusa F213 and Lactobacillus rhamnosus FBB81 probiotic candidates in an in vitro model of hydrogen peroxide-induced inflammatory bowel disease.
BMC Res Notes. 2020 Oct 20;13(1):489. doi:10.1186/s13104-020-05338-1.
- Sakaguchi Y, Uchiyama J, Také A, Gotoh K, Sakaguchi M, Suzuki T, Yamamoto Y, Hosomi K, Kohda T, Mukamoto M, Kozaki S, Hayashi S, Oguma K.
Analysis of a plasmid encoding botulinum neurotoxin type G gene in Clostridium argentinense.
Anaerobe. 2020 Oct 12;66:102281. doi: 10.1016/j.anaerobe.2020.102281.
- Yamamoto KI, Kagawa H, Arimoto S, Tan XW, Yasui K, Oshiki T, Sakaguchi M.
Cytotoxic Effects of Alcohol Extracts from a Plastic Wrap (Polyvinylidene Chloride) on Human Cultured Liver Cells and Mouse Primary Cultured Liver Cells.
Acta Med Okayama. 2020 Aug;74(4):327-334. doi: 10.18926/AMO/60371.
- Gao S, Wake H, Sakaguchi M, Wang D, Takahashi Y, Teshigawara K, Zhong H, Mori S, Liu K, Takahashi H, Nishibori M.
Histidine-Rich Glycoprotein Inhibits High-Mobility Group Box-1-Mediated Pathways in Vascular Endothelial Cells through CLEC-1A.
iScience. 2020 Jun 26;23(6):101180. doi: 10.1016/j.isci.2020.101180.
- Tomonobu N, Kinoshita R, Sakaguchi M.
exMCAM-Fc, an S100A8/A9-mediated-metastasis blocker, efficiently reduced the number of circulating tumor cells that appeared in the blood flow.
Mol Biol Rep. 2020 Jun;47(6):4879-4883. doi:10.1007/s11033-020-05495-3.
- Sato H, Schoenfeld AJ, Siau E, Lu YC, Tai H, Suzawa K, Kubota D, Lui AJ, Qeriqi B, Mattar M, Offin M, Sakaguchi M, Toyooka S, Drilon A, Rosen N, Kris MG, Solit DB, de Stanchina E, Davare MA, Riely GJ, Ladanyi M, Somwar R.
MAPK pathway alterations correlate with poor survival and drive resistance to therapy in patients with lung cancers driven by ROS1 fusions.
Clin Cancer Res. 2020 Jun 15;26(12):2932-2945. doi: 10.1158/1078-0432.CCR-19-3321.
- Kasano-Camones CI, Takizawa M, Iwasaki W, Sasaki S, Hamada M, Morimoto A, Sakaguchi M, Gonzalez FJ, Inoue Y.
Synergistic regulation of hepatic Fsp27b expression by HNF4α and CREBH.
Biochem Biophys Res Commun. 2020 Sep 17;530(2):432-439. doi: 10.1016/j.bbrc.2020.05.070.
- Tomonobu N, Komalasari NLGY, Sumardika IW, Jiang F, Chen Y, Yamamoto KI, Kinoshita R, Murata H, Inoue Y, Sakaguchi M.
Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the lutathione level.
Chem Biol Interact. 2020 Jun 1;324:109085. doi:10.1016/j.cbi.2020.109085.
- Bajkowska K, Sumardika IW, Tomonobu N, Chen Y, Yamamoto KI, Kinoshita R, Murata H, Gede Yoni Komalasari NL, Jiang F, Yamauchi A, Winarsa Ruma IM, Kasano-Camones CI, Inoue Y, Sakaguchi M.
Neuroplastinβ-mediated upregulation of solute carrier family 22 member 18 antisense (SLC22A18AS) plays a crucial role in the epithelial-mesenchymal transition, leading to lung cancer cells' enhanced motility.
Biochem Biophys Rep. 2020 May 17;22:100768. doi:10.1016/j.bbrep.2020.100768.
- Miyauchi S, Shien K, Takeda T, Araki K, Nakata K, Miura A, Takahashi Y, Kurihara E, Ogoshi Y, Namba K, Suzawa K, Yamamoto H, Okazaki M, Soh J, Tomida S, Yamane M, Sakaguchi M, Toyooka S.
Antitumor Effects of Pan-RAF Inhibitor LY3009120 Against Lung Cancer Cells Harboring Oncogenic BRAF Mutation.
Anticancer Res. 2020 May;40(5):2667-2673. doi: 10.21873/anticanres.14237.
- Tomonobu N, Kinoshita R, Sakaguchi M.
S100 Soil Sensor Receptors and Molecular Targeting Therapy Against Them in Cancer Metastasis.
Transl Oncol. 2020 Mar 16;13(4):100753. doi: 10.1016/j.tranon.2020.100753.
- Ueki Y, Saito K, Iioka H, Sakamoto I, Kanda Y, Sakaguchi M, Horii A, Kondo E.
PLOD2 Is Essential to Functional Activation of Integrin β1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas.
iScience. 2020 Feb 21;23(2):100850. doi: 10.1016/j.isci.2020.100850.
2019
- Ueki Y, Saito K, Iioka H, Maruyama S, Sumardika IW, Sakaguchi M, Kondo E.
PODXL1 promotes metastasis of the pancreatic ductal adenocarcinoma by activating the
C5aR/C5a axis from the tumor microenvironment.
Neoplasia.2019 Nov 20;21(12):1121-1132. doi: 10.1016/j.neo.2019.09.003.
- Nishimura Y, Wake H, Teshigawara K, Wang D, Sakaguchi M, Otsuka F, Nishibori M.
Histidine-rich glycoprotein augments natural killer cell function by modulating PD-1 expression via CLEC-1B.
Pharmacol Res Perspect. 2019 May 22;7(3):e00481. doi: 10.1002/prp2.481. eCollection 2019 Jun.
- Chen Y, Sumardika IW, Tomonobu N, Kinoshita R, Inoue Y, Iioka H, Mitsui Y,
Saito K, Ruma IMW, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K,
Yamamoto H, Soh J, Futami J, Kubo M, Putranto EW, Murakami T, Liu M, Hibino T,
Nishibori M, Kondo E, Toyooka S, Sakaguchi M.
Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness. Neoplasia.
2019 May 14;21(7):627-640. doi: 10.1016/j.neo.2019.04.006.
- Mitsui Y, Tomonobu N, Watanabe M, Kinoshita R, Sumardika W, Youyi C, Murata H,
Yamamoto KI, Sadahira T, Rodrigo AGH, Takamatsu H, Araki K, Yamauchi A, Yamamura
M, Fujiwara H, Inoue Y, Futami J, Saito K, Iioka H, Kondo E, Nishibori M, Toyooka
S, Yamamoto Y, Nasu Y, Sakaguchi M.
Upregulation of mobility in pancreatic cancer cells by secreted S100A11 through activation of surrounding fibroblasts.
Oncol Res. 2019 Apr 17. doi: 10.3727/096504019X15555408784978.
- Iioka H, Saito K, Sakaguchi M, Tachibana T, Homma K, Kondo E.
Crumbs3 is a critical factor that regulates invasion and metastasis of colon adenocarcinoma
via the specific interaction with FGFR1.
Int J Cancer. 2019 Apr 13. doi:10.1002/ijc.32336.
- Chen Y, Sumardika IW, Tomonobu N, Winarsa Ruma IM, Kinoshita R, Kondo E, Inoue
Y, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh
J, Liu M, Futami J, Sasai K, Katayama H, Kubo M, Putranto EW, Hibino T, Sun B,
Nishibori M, Toyooka S, Sakaguchi M.
Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion.
Cancer Lett. 2019 Jun 28;452:178-190. doi:10.1016/j.canlet.2019.03.023.
- Tomonobu N, Kinoshita R, Sumardika IW, Chen Y, Inoue Y, Yamauchi A, Yamamoto
KI, Murata H, Sakaguchi M.
Convenient methodology for extraction and subsequent selective propagation of mouse melanocytes in culture from adult mouse skin tissue.
Biochem Biophys Rep. 2019 Feb 22;18:100619. doi:10.1016/j.bbrep.2019.100619. eCollection 2019 Jul.
- Ogoshi Y, Shien K, Yoshioka T, Torigoe H, Sato H, Sakaguchi M, Tomida S, Namba
K, Kurihara E, Takahashi Y, Suzawa K, Yamamoto H, Soh J, Toyooka S.
Anti-tumor effect of neratinib against lung cancer cells harboring HER2 oncogene alterations.
Oncol Lett. 2019 Mar;17(3):2729-2736. doi:10.3892/ol.2019.9908.
- Takamatsu H, Yamamoto KI, Tomonobu N, Murata H, Inoue Y, Yamauchi A, Sumardika IW,
Youyi C, Kinoshita R, Yamamura M, Fujiwara H, Mitsui Y, Araki K, Futami J,
Saito K, Iioka H, Ruma IMW, Putranto EW, Nishibori M, Kondo E, Yamamoto Y, Toyooka S, Sakaguchi M.
Extracellular S100A11 plays a critical role in spread of the fibroblast population in pancreatic cancers.
Oncol Res. 2019 Mar 8. doi:10.3727/096504018X15433161908259.
- Sumardika IW, Chen Y, Tomonobu N, Kinoshita R, Ruma IMW, Sato H, Kondo E,Inoue Y, Yamauchi A, Murata H, Yamamoto KI,
Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Putranto EW, Hibino T, Nishibori M, Toyooka S, Sakaguchi M.
NEUROPLASTIN-β MEDIATES S100A8/A9-INDUCED LUNG CANCER DISSEMINATIVE PROGRESSION.
Mol Carcinog. 2019 Feb 5. doi: 10.1002/mc.22987.
2018
- Sasaki S, Hara A, Sakaguchi M, Nangaku M, Inoue Y.
Hepatocyte nuclear factor 4α regulates megalin expression in proximal tubular cells.
Biochem Biophys Rep.2018 Dec 12;17:87-92. doi: 10.1016/j.bbrep.2018.11.010.
- Kinoshita R, Sato H, Yamauchi A, Takahashi Y, Inoue Y, Sumardika IW, Chen Y,
Tomonobu N, Araki K, Shien K, Tomida S, Torigoe H, Namba K, Kurihara E, Ogoshi Y,
Murata H, Yamamoto KI, Futami J, Putranto EW, Ruma IMW, Yamamoto H, Soh J, Hibino
T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M.
Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis.
Int J Cancer. 2018 Nov 10. doi: 10.1002/ijc.31982.
- Kinoshita R, Sato H, Yamauchi A, Takahashi Y, Inoue Y, Sumardika IW, Chen Y,
Tomonobu N, Araki K, Shien K, Tomida S, Torigoe H, Namba K, Kurihara E, Ogoshi Y,
Murata H, Yamamoto KI, Futami J, Putranto EW, Winarsa Ruma IM, Yamamoto H, Soh J,
Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M.
exSSSRs (extracellular S100 Soil Sensor Receptors)-Fc fusion proteins work as prominent decoys to
S100A8/A9-induced lung tropic cancer metastasis.
Int J Cancer. 2018 Oct 26. doi:10.1002/ijc.31945.
- Murata H, Khine CC, Nishikawa A, Yamamoto KI, Kinoshita R, Sakaguchi M.
JNK-mediated phosphorylation of SARM1 regulates NAD(+) cleavage activity to
inhibit mitochondrial respiration.
J Biol Chem. 2018 Oct 17. pii:jbc.RA118.004578. doi: 10.1074/jbc.RA118.004578.
- Sasaki S, Urabe M, Maeda T, Suzuki J, Irie R, Suzuki M, Tomaru Y, Sakaguchi M,
Gonzalez FJ, Inoue Y.
Induction of hepatic metabolic functions by a novel variant
of hepatocyte nuclear factor 4γ.
Mol Cell Biol. 2018 Sep 17. pii: MCB.00213-18. doi: 10.1128/MCB.00213-18.
- Nakamura K, Sakaguchi M, Matsubara H, Akagi S, Sarashina T, Ejiri K, Akazawa
K, Kondo M, Nakagawa K, Yoshida M, Miyoshi T, Ogo T, Oto T, Toyooka S,
Higashimoto Y, Fukami K, Ito H.
Crucial role of RAGE in inappropriate increase of
smooth muscle cells from patients with pulmonary arterial hypertension.
PLoS One.2018 Sep 4;13(9):e0203046. doi: 10.1371/journal.pone.0203046.
- Saito K, Sakaguchi M, Maruyama S, Iioka H, Putranto EW, Sumardika IW, Tomonobu
N, Kawasaki T, Homma K, Kondo E.
Stromal mesenchymal stem cells facilitate
pancreatic cancer progression by regulating specific secretory molecules through
mutual cellular interaction.
J Cancer. 2018 Jul 30;9(16):2916-2929. doi:10.7150/jca.24415.
- Sato H, Yamamoto H, Sakaguchi M, Shien K, Tomida S, Shien T, Ikeda H, Hatono
M, Torigoe H, Namba K, Yoshioka T, Kurihara E, Ogoshi Y, Takahashi Y, Soh J, Toyooka S.
Combined inhibition of MEK and PI3K pathways overcomes acquired
resistance to EGFR-TKIs in non-small cell lung cancer.
Cancer Sci. 2018 Oct;109(10):3183-3196. doi: 10.1111/cas.13763.
- Ruma IMW, Kinoshita R, Tomonobu N, Inoue Y, Kondo E, Yamauchi A, Sato H,
Sumardika IW, Chen Y, Yamamoto KI, Murata H, Toyooka S, Nishibori M, Sakaguchi M.
Embigin Promotes Prostate Cancer Progression by S100A4-Dependent and-Independent
Mechanisms.
Cancers (Basel). 2018 Jul 23;10(7). pii: E239. doi:10.3390/cancers10070239.
- Torigoe H, Yamamoto H, Sakaguchi M, Youyi C, Namba K, Sato H, Shien K, Soh J,
Suzawa K, Tomida S, Tsukuda K, Miyoshi S, Toyooka S.
Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring
mutant EGFR.
Carcinogenesis. 2018 May 3;39(5):719-727. doi:10.1093/carcin/bgy044.
- Zhong H, Wake H, Liu K, Gao Y, Teshigawara K, Sakaguchi M, Mori S, Nishibori M.
Effects of Histidine-rich glycoprotein on erythrocyte aggregation and
hemolysis: Implications for a role under septic conditions.
J Pharmacol Sci. 2018 Mar;136(3):97-106. doi: 10.1016/j.jphs.2017.11.003.
- Torigoe H, Shien K, Takeda T, Yoshioka T, Namba K, Sato H, Suzawa K, Yamamoto
H, Soh J, Sakaguchi M, Tomida S, Tsukuda K, Miyoshi S, Toyooka S.
Therapeutic strategies for afatinib-resistant lung cancer harboring HER2 alterations.
Cancer Sci. 2018 May;109(5):1493-1502. doi: 10.1111/cas.13571.
- Kataoka K, Maehara N, Ayabe Y, Murata H, Huh NH, Sakaguchi M.
Tumor necrosis factor-α downregulates the REIC/Dkk-3 tumor suppressor gene in normal human skin
keratinocytes.
Mol Med Rep. 2018 May;17(5):6661-6666. doi: 10.3892/mmr.2018.8676.
- Sato H, Sakaguchi M, Yamamoto H, Tomida S, Aoe K, Shien K, Yoshioka T, Namba
K, Torigoe H, Soh J, Tsukuda K, Tao H, Okabe K, Miyoshi S, Pass HI, Toyooka S.
Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma.
Oncogenesis. 2018 Jan 24;7(1):11. doi: 10.1038/s41389-017-0017-3.
2017
- Sakaguchi M, Kinoshita R, Putranto EW, Ruma IMW, Sumardika IW, Youyi C,
Tomonobu N, Yamamoto KI, Murata H.
Exogenous DKK-3/REIC inhibits Wnt/β-catenin signaling and cell proliferation in human kidney cancer KPK1.
Signal Diversity of Receptor for Advanced Glycation End Products.
Acta Med Okayama. 2017 Dec;71(6):459-465. doi:10.18926/AMO/55582.
- Xu J, Sadahira T, Kinoshita R, Li SA, Huang P, Wada K, Araki M, Ochiai K,
Noguchi H, Sakaguchi M, Nasu Y, Watanabe M.
Exogenous DKK-3/REIC inhibits
Wnt/β-catenin signaling and cell proliferation in human kidney cancer KPK1.
Oncol Lett. 2017 Nov;14(5):5638-5642. doi: 10.3892/ol.2017.6833.
- Sumardika IW, Youyi C, Kondo E, Inoue Y, Ruma IMW, Murata H, Kinoshita R,
Yamamoto KI, Tomida S, Shien K, Satoh H, Yamauchi A, Futami J, Putranto EW,
Hibino T, Toyooka S, Nishibori M, Sakaguchi M.
ß-1,3-galactosyl-O-glycosyl-glycoprotein ß-1,6-N-acetylglucosaminyltransferase 3
Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.
Oncol Res. 2017 Sep 18. doi: 10.3727/096504017X15031557924123.
- Sakaguchi M.
S100-SPECT uncovers cellular and molecular events of
pre-metastatic niche formation and following organ-specific cancer metastasis.
Theranostics. 2017 Jun 25;7(10):2649-2651. doi: 10.7150/thno.19866. eCollection 2017.
- Wada T, Sumardika IW, Saito S, Ruma IMW, Kondo E, Shibukawa M, Sakaguchi M.
Identification of a novel component leading to anti-tumor activity besides the
major ingredient cordycepin in Cordyceps militaris extract.
J Chromatogr B Analyt
Technol Biomed Life Sci. 2017 Jul 19;1061-1062:209-219. doi:10.1016/j.jchromb.2017.07.022.
- Putranto EW, Kinoshita R, Watanabe M, Sadahira T, Murata H, Yamamoto KI,
Futami J, Kataoka K, Inoue Y, Winarsa Ruma IM, Sumardika IW, Youyi C, Kubo M,
Sakaguchi Y, Saito K, Nasu Y, Kumon H, Huh NH, Sakaguchi M.
Expression of tumor
suppressor REIC/Dkk-3 by a newly improved adenovirus vector with insertion of a
hTERT promoter at the 3'-side of the transgene.
Oncol Lett. 2017 Jul;14(1):1041-1048. doi: 10.3892/ol.2017.6201.
- Sakaguchi M, Sadahira T, Ueki H, Kinoshita R, Murata H, Yamamoto KI, Futami J,
Nasu Y, Ochiai K, Kumon H, Huh NH, Watanabe M.
Robust cancer-specific gene expression by a novel cassette with hTERT and CMV promoter elements.
Oncol Rep. 2017 Jun 12. doi: 10.3892/or.2017.5710.
- Morimoto A, Kannari M, Tsuchida Y, Sasaki S, Saito C, Matsuta T, Maeda T,
Akiyama M, Nakamura T, Sakaguchi M, Nameki N, Gonzalez FJ, Inoue Y.
An HNF4α-microRNA-194/192 Signaling Axis Maintains Hepatic Cell Function.
J Biol Chem. 2017 May 2. doi: 10.1074/jbc.M117.785592.
- 阪口政清, 山本真実, 宮井雅史, 松元 有羽子, 木下理恵, 村田 等, 山本健一,
森実 真, 岩月啓氏, 許 南浩, 坪井良治, 日比野 利彦.
Neuroplastinβとextracellular matrix metalloprotease inducerはS100A8/A9に対する機能的な受容体であり,
ケラチノサイトの増殖とアトピーの皮膚炎症の増強に関与している
Critical role of novel receptors to S100A8/A9, EMMPRIN and NPTNβ,
on keratinocyte growth and inflammation in atopic dermatitis.
「臨床免疫、アレルギー科」 2017 Jun.
- 阪口政清, 木下理恵, 村田 等, 山本健一, 許 南浩, 日比野 利彦.
転移先臓器を感知する受容体群
Innovative approach to prevent cancer metastasis based on S100A8/A9-mediated seed and soil theory.
月刊「細胞」 2017 Mar 20 6;49(3):39-42.
- Sawahara H, Shiraha H, Uchida D, Kato H, Kato R, Oyama A, Nagahara T, Iwamuro
M, Horiguchi S, Tsutsumi K, Mandai M, Mimura T, Wada N, Takeuchi Y, Kuwaki K,
Onishi H, Nakamura S, Watanabe M, Sakaguchi M, Takaki A, Nouso K, Yagi T, Nasu Y,
Kumon H, Okada H.
Promising therapeutic efficacy of a novel REIC/Dkk-3 expressing
adenoviral vector for hepatocellular carcinoma.
J Gastroenterol Hepatol. 2017 Feb 6. doi: 10.1111/jgh.13757.
- Suzawa K, Shien K, Peng H, Sakaguchi M, Watanabe M, Hashida S, Maki Y,
Yamamoto H, Tomida S, Soh J, Asano H, Tsukuda K, Nasu Y, Kumon H, Miyoshi S, Toyooka S.
Distant Bystander Effect of REIC/DKK3 Gene Therapy Through Immune
System Stimulation in Thoracic Malignancies.
Anticancer Res. 2017
Jan;37(1):301-307.
2016
- Ohtsuka T, Sakaguchi M, Yamamoto H, Tomida S, Takata K, Shien K, Hashida S,
Miyata-Takata T, Watanabe M, Suzawa K, Soh J, Youyi C, Sato H, Namba K, Torigoe
H, Tsukuda K, Yoshino T, Miyoshi S, Toyooka S.
Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway.
Sci Rep. 2016 Dec 23;6:39557.
- Oka T, Kurozumi K, Shimazu Y, Ichikawa T, Ishida J, Otani Y, Shimizu T, Tomita
Y, Sakaguchi M, Watanabe M, Nasu Y, Kumon H, Date I.
A super gene expression
system enhances the anti-glioma effects of adenovirus-mediated REIC/Dkk-3 gene
therapy.
Sci Rep. 2016 Sep 14;6:33319.
- Sawahara H, Shiraha H, Uchida D, Kato H, Nagahara T, Iwamuro M, Kataoka J, Horiguchi S, Watanabe M, Sakaguchi M, Takaki A, Nouso K, Nasu Y, Kumon H, Okada H.
Novel REIC/Dkk-3-encoding adenoviral vector as a promising therapeutic agent for pancreatic cancer.
Cancer Gene Ther. 2016 Jul 29.
- Sakaguchi M, Yamamoto M, Miyai M, Maeda T, Hiruma J, Murata H, Kinoshita R,
Ruma IM, Putranto EW, Inoue Y, Morizane S, Huh NH, Tsuboi R, Hibino T.
Identification of an S100A8 receptor neuroplastin-β and its heterodimer formation
with EMMPRIN.
J Invest Dermatol. 2016 Jul 4. pii: S0022-202X(16)32093-0.
- Saho S, Satoh H, Kondo E, Inoue Y, Yamauchi A, Murata H, Kinoshita R, Yamamoto
KI, Futami J, Putranto EW, Ruma IM, Sumardika IW, Youyi C, Suzawa K, Yamamoto H,
Soh J, Tomida S, Sakaguchi Y, Saito K, Iioka H, Huh NH, Toyooka S, Sakaguchi M.
Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma
Cells.
Cancer Microenviron. 2016 Jun 22.
- Wake H, Mori S, Liu K, Morioka Y, Teshigawara K, Sakaguchi M, Kuroda K, Gao Y,
Takahashi H, Ohtsuka A, Yoshino T, Morimatsu H, Nishibori M.
Histidine-Rich
Glycoprotein Prevents Septic Lethality through Regulation of Immunothrombosis and
Inflammation.
EBioMedicine. 2016 Jun 4. pii: S2352-3964(16)30247-X.
- Ruma IM, Putranto EW, Kondo E, Murata H, Watanabe M, Huang P, Kinoshita R,
Futami J, Inoue Y, Yamauchi A, Sumardika IW, Youyi C, Yamamoto K, Nasu Y,
Nishibori M, Hibino T, Sakaguchi M.
MCAM, as a novel receptor for S100A8/A9,
mediates progression of malignant melanoma through prominent activation of NF-κB
and ROS formation upon ligand binding.
Clin Exp Metastasis. 2016 Aug;33(6):609-27. doi: 10.1007/s10585-016-9801-2. Epub 2016 May 5.
- Ichiki T, Koga T, Okuno T, Saeki K, Yamamoto Y, Yamamoto H, Sakaguchi M, Yokomizo T.
Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products (RAGE).
FASEB J. 2016 Jan 26. pii: fj.201500117.
- Suzawa K, Toyooka S, Sakaguchi M, Morita M, Yamamoto H, Tomida S, Ohtsuka T,
Watanabe M, Hashida S, Maki Y, Soh J, Asano H, Tsukuda K, Miyoshi S.
Antitumor effect of afatinib, as a HER2-targeted therapy, in lung cancers harboring HER2
oncogene alterations.
Cancer Sci. 2016 Jan;107(1):45-52.
- Futami J, Atago Y, Azuma A, Putranto EW, Kinoshita R, Murata H, Sakaguchi M.
An efficient method for the preparation of preferentially heterodimerized recombinant S100A8/A9 coexpressed in Escherichia coli.
Biochem Biophys Rep. 6: 94-100, 2016.
2015
- Murata H, Takamatsu H, Liu S, Kataoka K, Huh NH, Sakaguchi M.
NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions.
PLoS One. 2015 Nov 10;10(11)
- Matsuo S, Ogawa M, Muckenthaler MU, Mizui Y, Sasaki S, Fujimura T, Takizawa M,
Ariga N, Ozaki H, Sakaguchi M, Gonzalez FJ, Inoue Y.
Hepatocyte Nuclear Factor 4α Controls Iron Metabolism and Regulates Transferrin Receptor 2 in Mouse Liver.
J Biol Chem. 2015 Dec 25;290(52):30855-65.
- Futami J, Nonomura H, Kido M, Niidoi N, Fujieda N, Hosoi A, Fujita K, Mandai
K, Atago Y, Kinoshita R, Honjo T, Matsushita H, Uenaka A, Nakayama E, Kakimi K.
Sensitive Multiplexed Quantitative Analysis of Autoantibodies to Cancer Antigens
with Chemically S-Cationized Full-Length and Water-Soluble Denatured Proteins.
Bioconjug Chem. 2015 Oct 21;26(10):2076-84.
- Otani H, Yamamoto H, Takaoka M, Sakaguchi M, Soh J, Jida M, Ueno T, Kubo T,
Asano H, Tsukuda K, Kiura K, Hatakeyama S, Kawahara E, Naomoto Y, Miyoshi S, Toyooka S.
TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant
Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells.
PLoS One. 2015 Jun 19;10(6)
- Kinoshita R, Watanabe M, Huang P, Li SA, Sakaguchi M, Kumon H, Futami J.
The cysteine-rich core domain of REIC/Dkk-3 is critical for its effect on monocyte
differentiation and tumor regression.
Oncol Rep. 2015 Jun;33(6):2908-14.
- Fujio K, Watanabe M, Ueki H, Li SA, Kinoshita R, Ochiai K, Futami J, Watanabe
T, Nasu Y, Kumon H.
A vaccine strategy with multiple prostatic acid
phosphatase-fused cytokines for prostate cancer treatment.
Oncol Rep. 2015 Apr;33(4):1585-92.
2014
- Sakaguchi M, Murata H, Aoyama Y, Hibino T, Putranto EW, Ruma IM, Inoue Y,
Sakaguchi Y, Yamamoto KI, Kinoshita R, Futami J, Kataoka K, Iwatsuki K, Huh NH.
DNAX-Activating Protein 10 (DAP10) Membrane Adaptor Associates with Receptor for
Advanced Glycation End Products (RAGE) and Modulates the RAGE-triggered Signaling
Pathway in Human Keratinocytes.
J Biol Chem. 2014 Aug 22;289(34):23389-402.
- Jaiswal JK, Lauritzen SP, Scheffer L, Sakaguchi M, Bunkenborg J, Simon SM,
Kallunki T, Jäättelä M, Nylandsted J.
S100A11 is required for efficient plasma
membrane repair and survival of invasive cancer cells.
Nat Commun. 2014 May 8;5:3795.
- Ruma IM, Putranto EW, Kondo E, Watanabe R, Saito K, Inoue Y, Yamamoto KI,
Nakata S, Kaihata M, Murata H, Sakaguchi M.
Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma
cells.
Int J Oncol. 2014 Apr 24.
- Ueno T, Toyooka S, Fukazawa T, Kubo T, Soh J, Asano H, Muraoka T, Tanaka N,
Maki Y, Shien K, Furukawa M, Sakaguchi M, Yamamoto H, Tsukuda K, Miyoshi S.
Preclinical evaluation of microRNA-34b/c delivery for malignant pleural
mesothelioma.
Acta Med Okayama. 2014 Feb;68(1):23-6.
- Sakaguchi M, Watanabe M, Kinoshita R, Kaku H, Ueki H, Futami J, Murata H,
Inoue Y, Li SA, Huang P, Putranto EW, Ruma IM, Nasu Y, Kumon H, Huh NH.
Dramatic Increase in Expression of a Transgene by Insertion of Promoters Downstream of the
Cargo Gene.
Mol Biotechnol. 2014 Feb 14.
- Shien K, Tanaka N, Watanabe M, Soh J, Sakaguchi M, Matsuo K, Yamamoto H,
Furukawa M, Asano H, Tsukuda K, Nasu Y, Huh NH, Miyoshi S, Kumon H, Toyooka S.
Anti-cancer effects of REIC/Dkk-3-encoding adenoviral vector for the treatment of
non-small cell lung cancer.
PLoS One. 2014 Feb 3;9(2):e87900.
- Sakaguchi Y, Hosomi K, Uchiyama J, Ogura Y, Umeda K, Sakaguchi M, Kohda T,
Mukamoto M, Misawa N, Matsuzaki S, Hayashi T, Kozaki S.
Draft Genome Sequence of Clostridium botulinum Type B Strain Osaka05, Isolated
from an Infant Patient with Botulism in Japan.
Genome Announc. 2014 Jan 23;2(1).
- Saito K, Sakaguchi M, Iioka H, Matsui M, Nakanishi H, Huh NH, Kondo E.
Coxsackie and adenovirus receptor is a critical regulator for the survival and growth of oral squamous carcinoma cells.
Oncogene. 2014 Mar 6;33(10):1274-86.
- Watanabe M, Sakaguchi M, Kinoshita R, Kaku H, Ariyoshi Y, Ueki H, Tanimoto R,
Ebara S, Ochiai K, Futami J, Li SA, Huang P, Nasu Y, Huh NH, Kumon H.
A novelgene expression system strongly enhances the anticancer effects of a
REIC/Dkk-3-encoding adenoviral vector.
Oncol Rep. 2014 Mar;31(3):1089-95.
- Yamamoto H, Higasa K, Sakaguchi M, Shien K, Soh J, Ichimura K, Furukawa M,
Hashida S, Tsukuda K, Takigawa N, Matsuo K, Kiura K, Miyoshi S, Matsuda F,
Toyooka S.
Novel Germline Mutation in the Transmembrane Domain of HER2 in
Familial Lung Adenocarcinomas.
J Natl Cancer Inst. 2014 Jan;106(1).
2013
- Murata H, Sakaguchi M, Kataoka K, Huh NH.
SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria.
Mol Biol Cell. 2013 Sep;24(18):2772-84.
- Putranto EW, Murata H, Yamamoto K, Kataoka K, Yamada H, Futami J, Sakaguchi M, Huh NH.
Inhibition of RAGE signaling through the intracellular delivery of inhibitor peptides by PEI cationization.
Int J Mol Med. 2013 Oct;32(4):938-44.
- Ohashi M, Oyama T, Putranto EW, Waku T, Nobusada H, Kataoka K, Matsuno K, Yashiro M, Morikawa K, Huh NH, Miyachi H.
Design and synthesis of a series of α-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility.
Bioorg Med Chem. 2013 Apr 15;21(8):2319-32.
- Yamamoto K, Murata H, Putranto EW, Kataoka K, Motoyama A, Hibino T, Inoue Y, Sakaguchi M, Huh NH.
DOCK7 is a critical regulator of the RAGE-Cdc42 signaling
axis that induces formation of dendritic pseudopodia in human cancer cells.
Oncol Rep. 2013 Mar;29(3):1073-9.
- Hibino T, Sakaguchi M, Miyamoto S, Yamamoto M, Motoyama A, Hosoi J, Shimokata T, Ito T, Tsuboi R, Huh NH.
S100A9 Is a Novel Ligand of EMMPRIN That Promotes Melanoma Metastasis.
Cancer Res. 2013 Jan 1;73(1):172-83.
2012
- Sugimoto M, Watanabe M, Kaku H, Li SA, Noguchi H, Ueki H, Sakaguchi M, Huh NH, Nasu Y, Kumon H.
Preclinical biodistribution and safety study of reduced
expression in immortalized cells/Dickkopf-3-encoding adenoviral vector for
prostate cancer gene therapy.
Oncol Rep. 2012 Nov;28(5):1645-52.
- Futami M, Watanabe Y, Asama T, Murata H, Tada H, Kosaka M, Yamada H, Futami J.
Uniformly cationized protein efficiently reaches the cytosol of mammalian cells.
Bioconjug Chem. 2012 Oct 17;23(10):2025-31.
- Hirata T, Watanabe M, Kaku H, Kobayashi Y, Yamada H, Sakaguchi M, Takei K, Huh NH, Nasu Y, Kumon H.
REIC/Dkk-3-encoding adenoviral vector as a potentially effective therapeutic agent for bladder cancer.
Int J Oncol. 2012 Aug;41(2):559-64.
- Kataoka K, Du G, Maehara N, Murata H, Sakaguchi M, Huh N.
Expression pattern of REIC/Dkk-3 in mouse squamous epithelia.
Clin Exp Dermatol. 2012 Jun;37(4):428-31.
- Kawauchi K, Watanabe M, Kaku H, Huang P, Sasaki K, Sakaguchi M, Ochiai K, Huh NH, Nasu Y, Kumon H.
Preclinical safety and efficacy of in situ REIC/Dkk-3 gene therapy for prostate cancer.
Acta Med Okayama. 2012;66(1):7-16.
- Kataoka K, Ono T, Murata H, Morishita M, Yamamoto KI, Sakaguchi M, Huh NH.
S100A7 promotes the migration and invasion of osteosarcoma cells via the receptor
for advanced glycation end products.
Oncol Lett. 2012 May;3(5):1149-1153.
- Hayashi T, Asano H, Toyooka S, Tsukuda K, Soh J, Shien T, Taira N, Maki Y,Tanaka N, Doihara H, Nasu Y, Huh NH, Miyoshi S.
DNA methylation status of REIC/Dkk-3 gene in human malignancies.
J Cancer Res Clin Oncol. 2012 May;138(5):799-809.
- Jin Y, Murata H, Sakaguchi M, Kataoka K, Watanabe M, Nasu Y, Kumon H, Huh NH.
Partial sensitization of human bladder cancer cells to a gene-therapeutic adenovirus carrying REIC/Dkk-3 by downregulation of BRPK/PINK1.
Oncol Rep. 2012 Mar;27(3):695-9. doi: 10.3892/or.2011.1543.
2011
- Sakaguchi M, Huh NH.
S100A11, a dual growth regulator of epidermal keratinocytes.
Amino Acids. 2011 Oct;41(4):797-807.
- Ochiai K, Watanabe M, Ueki H, Huang P, Fujii Y, Nasu Y, Noguchi H, Hirata T, Sakaguchi M,
Huh NH, Kashiwakura Y, Kaku H, Kumon H.
Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-1.
Biochem Biophys Res Commun. 2011 Aug 26;412(2):391-5.
- Kubo T, Toyooka S, Tsukuda K, Sakaguchi M, Fukazawa T, Soh J, Asano H, Ueno T, Muraoka T, Yamamoto H, Nasu Y, Kishimoto T, Pass HI, Matsui H, Huh NH, Miyoshi S.
Epigenetic silencing of microRNA-34b/c plays an important role in the pathogenesis of malignant pleural mesothelioma.
Clin Cancer Res. 2011 Aug 1;17(15):4965-74.
- Murata H, Sakaguchi M, Kataoka K, Huh NH.
Multiple functions of PINK1 at different intracellular locations: beyond neurodegenerative diseases.
Cell Cycle. 2011 May 15;10(10):1518-9.
- Than SS, Kataoka K, Sakaguchi M, Murata H, Abarzua F, Taketa C, Du G, Yashiro M, Yanagihara K, Nasu Y, Kumon H, Huh NH.
Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma.
Oncol Rep. 2011 Apr;25(4):989-95. doi:10.3892/or.2011.1149.
- Murata H, Sakaguchi M, Jin Y, Sakaguchi Y, Futami J, Yamada H, Kataoka K, Huh NH.
A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2.
J Biol Chem. 2011 Mar 4;286(9):7182-9.
- Du G, Kataoka K, Sakaguchi M, Abarzua F, Than SS, Sonegawa H, Makino T, Shimizu T, Huh NH.
Expression of REIC/Dkk-3 in normal and hyperproliferative epidermis.
Exp Dermatol. 2011 Mar;20(3):273-7. doi:10.1111/j.1600-0625.2010.01244.x.
- Sakaguchi M, Huh NH, Namba M.
A novel tumor suppressor, REIC/Dkk-3 gene identified by our in vitro transformation model of normal human fibroblasts works as a potent therapeutic anti-tumor agent.
Adv Exp Med Biol. 2011;720:209-15.
- Sakaguchi M, Murata H, Yamamoto K, Ono T, Sakaguchi Y, Motoyama A, Hibino T, Kataoka K, Huh NH.
TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding. PLoS One. 2011;6(8):e23132.
2010
- Kataoka K, Sakaguchi M, Li KP, Taketa C, Yamamoto K, Du G, Funahashi H, Murata H, Huh NH.
Internalization of REIC/Dkk-3 protein by induced pluripotent stem cell-derived embryoid bodies and extra-embryonic tissues.
Int J Mol Med. 2010 Dec;26(6):853-9.
- Zhang K, Watanabe M, Kashiwakura Y, Li SA, Edamura K, Huang P, Yamaguchi K, Nasu Y, Kobayashi Y, Sakaguchi M, Ochiai K, Yamada H, Takei K, Ueki H, Huh NH, Li M, Kaku H, Na Y, Kumon H.
Expression pattern of REIC/Dkk-3 in various cell types and the implications of the soluble form in prostatic acinar development.
Int J Oncol. 2010 Dec;37(6):1495-501.
- Yamamoto K, Sakaguchi M, Medina RJ, Niida A, Sakaguchi Y, Miyazaki M, Kataoka K, Huh NH.
Transcriptional regulation of a brown adipocyte-specific gene, UCP1, by KLF11 and KLF15.
Biochem Biophys Res Commun. 2010 Sep 10;400(1):175-80.
- Tanimoto R, Sakaguchi M, Abarzua F, Kataoka K, Kurose K, Murata H, Nasu Y, Kumon H, Huh NH.
Down-regulation of BiP/GRP78 sensitizes resistant prostate cancer cells to gene-therapeutic overexpression of REIC/Dkk-3.
Int J Cancer. 2010 Apr 1;126(7):1562-9.
2009
- Chen J, Watanabe M, Huang P, Sakaguchi M, Ochiai K, Nasu Y, Ouchida M, Huh NH, Shimizu K, Kashiwakura Y, Kaku H, Kumon H.
REIC/Dkk-3 stable transfection reduces the malignant phenotype of mouse prostate cancer RM9 cells.
Int J Mol Med. 2009 Dec;24(6):789-94.
- Yang XZ, Kataoka K, Medina R, Yamamoto K, Than SS, Miyazaki M, Huh NH.
A novel three-dimensional culture system for isolation and clonal propagation of neural stem cells using a thermo-reversible gelation polymer.
Tissue Eng Part C Methods. 2009 Dec;15(4):615-23.
- Sakaguchi M, Kataoka K, Abarzua F, Tanimoto R, Watanabe M, Murata H, Than SS, Kurose K, Kashiwakura Y, Ochiai K, Nasu Y, Kumon H, Huh NH.
Overexpression of REIC/Dkk-3 in normal fibroblasts suppresses tumor growth via induction of
interleukin-7.
J Biol Chem. 2009 May 22;284(21):14236-44.
- Watanabe M, Kashiwakura Y, Huang P, Ochiai K, Futami J, Li SA, Takaoka M, Nasu Y, Sakaguchi M, Huh NH, Kumon H.
Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression.
Int J Oncol. 2009 Mar;34(3):657-63.
- Kawasaki K, Watanabe M, Sakaguchi M, Ogasawara Y, Ochiai K, Nasu Y, Doihara H, Kashiwakura Y, Huh NH, Kumon H, Date H.
REIC/Dkk-3 overexpression downregulates P-glycoprotein in multidrug-resistant MCF7/ADR cells and induces apoptosis in breast cancer.
Cancer Gene Ther. 2009 Jan;16(1):65-72.
- Hardjo M, Miyazaki M, Sakaguchi M, Masaka T, Ibrahim S, Kataoka K, Huh NH.
Suppression of carbon tetrachloride-induced liver fibrosis by transplantation of a clonal mesenchymal stem cell line derived from rat bone marrow.
Cell Transplant. 2009;18(1):89-99.
2008
- Kobayashi T, Sakaguchi M, Tanimoto R, Abarzua F, Takaishi M, Kaku H, Kataoka K, Saika T, Nasu Y, Miyazaki M, Kumon H, Huh NH.
Mechanistic analysis of resistance to REIC/Dkk-3-induced apoptosis in human bladder cancer cells.
Acta Med Okayama. 2008 Dec;62(6):393-401.
- Abarzua F, Kashiwakura Y, Takaoka M, Watanabe M, Ochiai K, Sakaguchi M, Iwawaki T, Tanimoto R, Nasu Y, Huh NH, Kumon H.
An N-terminal 78 amino acid truncation of REIC/Dkk-3 effectively induces apoptosis.
Biochem Biophys Res Commun. 2008 Oct 31;375(4):614-8.
- Kashiwakura Y, Ochiai K, Watanabe M, Abarzua F, Sakaguchi M, Takaoka M, Tanimoto R, Nasu Y, Huh NH, Kumon H.
Down-regulation of inhibition of differentiation-1 via activation of activating transcription factor 3 and Smad regulates REIC/Dickkopf-3-induced apoptosis.
Cancer Res. 2008 Oct 15;68(20):8333-41.
- Masaka T, Miyazaki M, Du G, Hardjo M, Sakaguchi M, Takaishi M, Kataoka K, Yamamoto K, Huh NH.
Derivation of hepato-pancreatic intermediate progenitor cells from a clonal mesenchymal stem cell line of rat bone marrow origin.
Int J Mol Med. 2008 Oct;22(4):447-52.
- Murata H, Futami J, Kitazoe M, Yonehara T, Nakanishi H, Kosaka M, Tada H, Sakaguchi M, Yagi Y, Seno M, Huh NH, Yamada H.
Intracellular delivery of glutathione S-transferase-fused proteins into mammalian cells by
polyethylenimine-glutathione conjugates.
J Biochem. 2008 Oct;144(4):447-55.
- Kouno T, Mizuguchi M, Sakaguchi M, Makino E, Mori Y, Shinoda H, Aizawa T, Demura M, Huh NH, Kawano K.
The structure of S100A11 fragment explains a local structural change induced by phosphorylation.
J Pept Sci. 2008 Oct;14(10):1129-38.
- Nukui T, Ehama R, Sakaguchi M, Sonegawa H, Katagiri C, Hibino T, Huh NH.
S100A8/A9, a key mediator for positive feedback growth stimulation of normal human keratinocytes.
J Cell Biochem. 2008 May 15;104(2):453-64.
- Murata H, Futami J, Kitazoe M, Kosaka M, Tada H, Seno M, Yamada H. Transient
cell proliferation with polyethylenimine-cationized N-terminal domain of simian virus 40 large T-antigen.
J Biosci Bioeng. 2008 Jan;105(1):34-8.
2007
- Sakaguchi M, Murata H, Sonegawa H, Sakaguchi Y, Futami J, Kitazoe M, Yamada H,Huh NH.
Truncation of annexin A1 is a regulatory lever for linking epidermal growth factor signaling with cytosolic phospholipase A2 in normal and malignant squamous epithelial cells.
J Biol Chem. 2007 Dec 7;282(49):35679-86.
- Miyazaki M, Hardjo M, Masaka T, Tomiyama K, Mahmut N, Medina RJ, Niida A, Sonegawa H, Du G, Yong R, Takaishi M, Sakaguchi M, Huh NH.
Isolation of a bone marrow-derived stem cell line with high proliferation potential and its application for preventing acute fatal liver failure.
Stem Cells. 2007 Nov;25(11):2855-63.
- Edamura K, Nasu Y, Takaishi M, Kobayashi T, Abarzua F, Sakaguchi M, Kashiwakura Y, Ebara S, Saika T, Watanabe M, Huh NH, Kumon H.
Adenovirus-mediated REIC/Dkk-3 gene transfer inhibits tumor growth and metastasis
in an orthotopic prostate cancer model.
Cancer Gene Ther. 2007 Sep;14(9):765-72.
- Abarzua F, Sakaguchi M, Tanimoto R, Sonegawa H, Li DW, Edamura K, Kobayashi T,Watanabe M, Kashiwakura Y, Kaku H, Saika T, Nakamura K, Nasu Y, Kumon H, Huh NH.
Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3.
Int J Mol Med. 2007 Jul;20(1):37-43.
- Sonegawa H, Nukui T, Li DW, Takaishi M, Sakaguchi M, Huh NH.
Involvement of deterioration in S100C/A11-mediated pathway in resistance of human squamous cancer cell lines to TGFbeta-induced growth suppression.
J Mol Med. 2007 Jul;85(7):753-62.
- Tomiyama K, Miyazaki M, Nukui M, Takaishi M, Nakao A, Shimizu N, Huh NH.
Limited contribution of cells of intact extrahepatic tissue origin to hepatocyte regeneration in transplanted rat liver.
Transplantation. 2007 Mar 15;83(5):624-30.
- Tanimoto R, Abarzua F, Sakaguchi M, Takaishi M, Nasu Y, Kumon H, Huh NH.
REIC/Dkk-3 as a potential gene therapeutic agent against human testicular cancer.
Int J Mol Med. 2007 Mar;19(3):363-8.
総説
-
Kataoka K, Huh NH.
Application of a Thermo-Reversible Gelation Polymer, Mebiol Gel, for Stem Cell Culture and Regenerative Medicine.
J Stem Cells and Regenerative Medicine. 2010 Apr;6:10-14.
著書
- 培養細胞実験ハンドブック
監修:黒木登志夫, 編集:許南浩, 中村幸夫
羊土社. 2009.1