Moriya, T., Surong, A., Tatsumi, N., Yamada, H., Takemoto, F., Kamioka, H., Okamura, H., Ikegame, M. Dynamin 2 is involved in osteoblast migration by regulating the organization of F-actin International Journal of Oral Bioscience, 68, 100720 (2026) doi: 10.1016/j.job.2025.100720
Nishii, N., Kawai, T., Yasuoka H., Abe, T., Tatsumi, N., Harada, Y., Miyaji, T., Li, S., Tsukano, M., Watanabe, M., Ogawa, D., Wada, J., Takei, K., Yamada, H. Vesicular Glutamate Transporter 3 Is Involved in Glutamatergic Signalling in Podocytes. International Journal of Molecular Sciences, 26, 2485 (2025) doi: 10.3390/ijms26062485
（特許）特願2025-159886令和724年9月26日
山田浩司、沼本修孝、成田哲博
「マラリアを治療するための薬剤の有効成分の探索方法」
Yamada, H., Osaka, H., Tatsumi, N., Araki, M., Abe, T., Kaihara, K., Takahashi, K., Takashima, E., Uchihashi, T., Naruse, K., Takei, K. Direct Binding of Synaptopodin 2-Like Protein to Alpha-Actinin Contributes to Actin Bundle Formation in Cardiomyocytes. Cells, 13, 1373 (2024) doi: https://doi.org/10.3390/cells13161373
Chang, C.J., Taoufiq, Z., Yamada, H., Takei, K., Tomiyama, T., Umeda, T., Hori, T., Takahashi, T. The microtubule-dynamin binding inhibitor peptide PHDP5 rescues spatial learning and memory deficits in Alzheimer’s disease model mice. Brain Res, 1838:148987 (2024) doi: https://doi.org/10.1016/j.brainres.2024.148987
Okuma, H., Saijo-Hamano, Y., Yamada H, Sherif, A.A., Hashizaki, E., Sakai, N., Kato, T., Imasaki, T., Kikkawa, S., Nitta, E., Sasai, M., Abe, T., Sugihara, F., Maniwa, Y., Kosako, H., Takei, K., Standley, D.M., Yamamoto, M., Nitta, R. Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I. Genes to Cells, 29, 17-38 (2024) doi: 10.1111/gtc.13080
Wint, H., Li, J., Abe, T., Yamada, H., Higaki, T., Nasu, Y., Watanabe, M., Takei, K., Takeda, T. Pacsin 2-dependent N-cadherin internalization regulates the migration behaviour of malignant cancer cells. Journal of Cell Science, jcs.26087 (2023) doi: https://doi.org/10.1242/jcs.260827
Yamada, H., Abe, T., Nagaoka, H., Takashima, E., Nitta, R., Yamamoto, M., Takei, K. Recruitment of Irgb6 to the Membrane is a Direct Trigger for Membrane Deformation. Frontiers in Cellular and Infection Microbiology, 12, 992198 (2022)
Hori, T., Eguchi, K., Wang, H.Y., Miyasaka, T., Guillaud, L., Taoufiq, Z., Mahapatra, S., Yamada, H., Takei, K., Takahashi, T. Microtubule assembly by soluble tau impairs vesicle endocytosis and excitatory neurotransmission via dynamin sequestration in Alzheimer's disease mice synapse model. Elife, 11, e73542 (2022)
Hamasaki, E., Wakita, N., Yasuoka H., Nagaoka, H., Morita, M., Takashima, E., Uchihashi, T., Takeda, T., Abe, T., Lee, J.W., Iimura, T., Saleem, M.A., Ogo, N., Asai, A., Narita, A., Kohji Takei, K.,Yamada, H. The Lipid-binding Defective Dynamin 2 mutant in Charcot-Marie-Tooth Disease Impairs Proper Actin Bundling and Actin Organization in Glomerular Podocytes. Frontiers in Cell and Developmental Biology, 10, 884509 (2022)
Ohta, J. A novel variant of the Calvin–Benson cycle bypassing fructose bisphosphate. Scientific Reports 12, 3984 (2022)
Fujise, K., Okubo, M., Abe, T., Yamada, H., Takei, K., Nishino, I., Tetsuya Takeda, T., Noguchi, S. Imaging-based evaluation of pathogenicity by novel DNM2 variants associated with centronuclear myopathy. Human Mutation, 43, 169-179 (2022)
Chan, F.-Y., Kurosaki, R., Ganser, C., Takeda, T., Uchihashi, T.: Tip-scan high-speed atomic force microscopy with a uniaxial substrate stretching device for studying dynamics of biomolecules under mechanical stress, 93, 113703 (2022)
Takeda, T., Yamada, H., Takei, K. Dynamin: molecular scissors for membrane fission. Plasma Membrane Shaping,77-90 (2022)
Fujise, K., Noguchi, S., Takeda, T. Centronuclear Myopathy Caused by Defective Membrane Remodelling of Dynamin 2 and BIN1 Variants. International Journal of Molecular Sciences 23, 6274 (2022)
Li, J., Fujise, K., Wint, H., Senju, Y., Suetsugu, S., Yamada, H., Takei, K., Takeda, T. Dynamin 2 and BAR domain protein Pacsin 2 cooperatively regulate formation and maturation of podosomes. Biochemical and Biophysical Research Communications, 571, 145-151 (2021)
Sakane, A., Yano, T.A., Uchihashi, T., Horikawa, K., Hara, Y., Imoto, I., Kurisu, S., Yamada, H., Takei, K., Sasaki, T. JRAB/MICAL-L2 undergoes liquid-liquid phase separation to form tubular recycling endosomes. Communications Biology, 4, 551 (2021)
Fujise, K., Okubo, M., Abe, T., Yamada, H., Nishino, I., Noguchi, S., Takei, K., Takeda, T. Mutant BIN1-Dynamin 2 complexes dysregulate membrane remodeling in the pathogenesis of centronuclear myopathy. Journal of Biological Chemistry, 296, 100077 (2020)
The Mon La , Tachibana, H., Li, S.A., Abe, T., Seiriki, S., Nagaoka, H., Takashima, E., Takeda, T., Ogawa, D., Makino, S., Asanuma, K., Watanabe, M., Tian, X., Ishibe, S., Sakane, A., Sasaki, T., Wada, J., Takei, K., Yamada, H. Dynamin 1 is important for microtubule organisation and stabilisation in glomerular podocytes. FASEB J. 34, 16449-16463 (2020)
The Mon La, Yamada, H., Seiriki, S., Li, S.A., Fujise, K., Katsumi, N., Abe, T., Watanabe, M., Takei, K. Internalization of AMPA-type glutamate receptor in the MIN6 pancreatic beta-cell line Cell Struct. Func., 45, 121-130 (2020)
Lee, Y., Yamada, H., Pradipta, A., Ma, J.S., Okamoto, M., Nagaoka, H., Takashima, E., Standley, D.M., Sasai, M., Takei, K., Yamamoto, M. Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense. Life Science Alliance, 3, e201900549 (2019)
Hirose, T., Cabrera-Socorro, A., Chitayat, D., Lemonnier, T., Feraud, O., Cifuentes-Diaz, C., Gervasi, N., Mombereau, C., Ghosh, T., Stoica, L., Jeanne d'arc, AL.B., Yamada, H., Lauterbach, M., Guillon, M., Kaneko, K., Norris, J.W., Siriwardena, K., Blaser, S., Teillon, J., Mendoza-Londono, R., Russeau, M., Hadoux, J., Ito, S., Corvol, P., Matheus, M.G., Holden, K.R., Takei, K., Emiliani, V., Bennaceur-Griscelli, A., Schwartz, C.E., Nguyen, G., Groszer, M. ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration. J. Clin. Invest., 129, 2145-2162 (2019)
Abe, T., The Mon La, Miyagaki, Y., Oya, E., Wei, F.Y., Sumida, K., Fujise, K., Takeda, T., Tomizawa, K., Takei, K., Yamada, H. Phosphorylation of cortactin by cyclin-dependent kinase 5 modulates actin bundling by the dynamin 1-cortactin ring-like complex and formation of filopodia and lamellipodia in NG108-15 glioma-derived cells. Int. J. Oncol., 54, 550-558 (2019)
竹居 孝二，山田 浩司，竹田 哲也 ダイナミン複合体による新規の膜切断機構, クラスタラーゼ・モデル 生物物理: 59, 255-261 (2019)
Takeda, T., Kozai ,T., Yang, H., Ishikuro, D., Seyama, K., Kumagai, Y., Abe, T., Yamada, H., Uchihashi, T., Ando, T., Takei, K. Dynamic clustering of dynamin-amphiphysin helices regulates membrane constriction and fission coupled with GTP hydrolysis. Elife, 7 (2018)
Zhang, Y., Nolan, M., Yamada, H., Watanabe, M., Nasu, Y., Takei, K., Takeda, T. Dynamin2 GTPase contributes to invadopodia formation in invasive bladder cancer cells. Biochem. Biophys. Res. Commun., 480, 409-414 (2016)
Hatanaka, T., Ogawa, D., Tachibana, H., Eguchi, J., Inoue, T., Yamada, H., Takei, K., Makino, H. and Wada, J. Inhibition of SGLT2 alleviates diabetic nephropathy by suppressing high glucose-induced oxidative stress in type 1 diabetic mice. Pharmacology Research and Perspectives, 4, e00239 (2016)
Yamada, H., Kobayashi, K., Zhang, Y., Takeda, T., Takei, K. Expression of dynamin 2 mutant associated with Charcot-Marie-Tooth disease leads to aberrant actin dynamics and lamellipodia formation. Neurosci. Lett., 628, 179-185, (2016)
Yamada , H., Takeda, T., Michiue, H., Abe, T., Takei, K. Actin bundling by dynamin 2 and cortactin is implicated in cell migration by stabilizing filopodia in human non-small cell lung carcinoma cells. Int. J. Oncol., 49, 877-886 (2016)
Hayashi, K., Michiue, H., Yamada, H., Takata, K., Nakayama, H., Wei, FY., Fujimura, A., Tazawa, H., Asai, A., Ogo, N., Miyachi, H., Nishiki, T., Tomizawa, K., Takei, K., Matsui, H. Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization. Sci. Rep., 6, 23372 (2016)
Yamada, H., Kikuchi, T., Masumoto, T., Wei, F., Abe, T., Takeda, T., Nishiki, T., Tomizawa, K., Watanabe, M., Matsui, H., Takei, K. Possible role of cortactin phosphorylation by protein kinase Cα in actin-bundle formation at growth cone. Biol. Cell, 107, 319-330 (2015).
Yamada H., Abe T., Li SA., Tago S., Huang P., Watanabe M., Ikeda S., Ogo N., Asai A., Takei K. N'-[4-(dipropylamino)benzylidene]-2-hydroxybenzohydrazide is a dynamin GTPase inhibitor that suppresses cancer cell migration and invasion by inhibiting actin polymerization. Biochem. Biophys. Res. Commun., 443, 511-517 (2014)
Tachibana H, Ogawa D, Sogawa N, Asanuma M, Miyazaki I, Terami N, Hatanaka T, Horiguchi CS, Nakatsuka A, Eguchi J, Wada J, Yamada H, Takei K, Makino H : Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice. Am. J. Physiol. Renal Physiol. 306, F105-115 (2014)
Yamada H, Abe T, Satoh A, Okazaki N, Tago S, Kobayashi K, Yoshida Y, Oda Y, Watanabe M, Tomizawa K, Matsui H, Takei K. Stabilization of actin bundles by a Dynamin 1 / Cortactin ring complex is necessary for growth cone filopodia. J. Neuroscience 33, 4514-4526 (2013)
（特許）特願2012-263317平成24年11月30日出願
道上宏之、林圭一郎、松井秀樹、山田浩司、竹居孝二、宮地弘幸、浅井章良
「フルボキサミンを配合することを特徴とする分子標的型抗癌剤（特に抗脳腫瘍治療薬剤：第二医薬品用途）
（特許）特願2012-137489平成24年6月19日
山田浩司、竹居孝二、道上宏之、松井秀樹、浅井章良
「抗浸潤薬の新規スクリーニング法および抗浸潤剤」
Ueki H., Watanabe M., Kaku H., Huang P., Li S.A., Ochiai K., Hirata T., Noguchi H., Yamada H., Takei K., Nasu Y., Kashiwakura Y., Kumon H. A novel gene expression system for detecting viable bladder cancer cells. Int. J. Oncol., 41, 135-140 (2012)
Hirata T., Watanabe M., Kaku H., Kobayashi Y., Yamada H., Sakaguchi M.,Takei K., Huh N.H., Nasu Y., Kumon H. REIC/Dkk-3-encoding adenoviral vector as a potentially effective therapeutic agent for bladder cancer. Int. J. Oncol., 41, 559-564 (2012)