Materials-based Biology 材料で作った人工環境を元に、細胞や組織の新しい機能を見出すアプローチ
01 Surrounding mechanical stiffness regulates tissue development and growth 周囲の硬さは生体組織の成長を制御する
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Bone mineralization
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Salivary gland development
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Meckel cartilage degeneration
Biomaterials, 2011/Tissue Eng C, 2015/J Cell Sci, 2017/J Dent Res, 2020/Adv Biol, 2022
02 Re-evaluation of tissue formation in engineering perspective 組織発生・成長過程の材料学的再評価
a Size change of femur marrow space マウス大腿骨骨髄腔サイズの変化
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Tissue Eng C, 2015
b Cell membrane fragments derived from cell rupture are nucleation site for early mineralization. 軟骨細胞の破裂の結果生じる細胞膜断片が初期石灰化の核となる
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Integrat Biol, 2018
c Roles of water on early mineralization 石灰化形成における水の役割理解
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J Biomed Mater Res A, 2020/ ACS Appl Bio Mater, 2019
Biology-based Materials 生命科学現象を元に、新しい材料や装置を開発するアプローチ
01 Ultra fast biomineralization 超高速石灰化の実現に向けた取組み
![](common/img/idea_img_08.jpg)
ACS Biomaterials, 2018
02 In vitro tissue synthesis In vitro組織合成
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Dev Dyn, 2019
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PLoS One, 2007
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Integrat Biol, 2012
03 New adhesives for biological tissue 新しい生体組織用接着材の開発
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Acta Biomater, 2017/Adv Mater Interfaces, 2020/J Mater Chem B, 2021
Devices for New Dentistry
01 Denture for assisting vocalization 声を失った人用の発語アシスト義歯
![](common/img/idea_img_14.jpg)
02 Automatic system for denture fabrication 自動義歯製作装置の開発
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NEDO(経産省)戦略的基盤技術高度化支援事業
(2014-2017)協力:柳下技研
03 Block denture 組み立て義歯(ブロック義歯)
![](common/img/idea_img_16.jpg)