Viruses understand cells most and manipulate cellular functions with a limited number of gene products. We aim to uncover the principles of various life phenomena by closely examining the sophisticated activities of these viruses. By making the best use of the fact we have acquired, we are pursuing research and development such as exploring treatments for viral infections, developing viral vectors, and controlling cellular functions using viruses.
BDV is a neuro—directed RNA virus. One of the characteristics of this virus is that it persists in the nucleus of cells. Acute infection with BDV can cause fatal encephalitis.Persistent infection with BDV has been reported to cause symptoms of mental illness. By analyzing the BDV, we aim to find clues for understanding the pathology of mental illness and the principle of behavior of non-self RNA in the nucleus.
About 40% of the human genome is occupied by retrotransposons (transposable elements). Among them, LINE-1 (long interspersed nuclear element-1) still repeats transpositions on the genome. Recent studies have revealed that there are interactions between these retrotransposons and various viruses. We are conducting broad research on the actual state of this interaction, its significance and mechanisms, using various viruses.
Human herpesvirus 6B (HHV-6B) is a persistent, latent co-infecting virus that causes sudden rashes in children and persists in the body throughout life. However, it can reactivate during blood stem cell transplantation and cause encephalitis or encephalopathy. Our research aims to reveal how this virus maintains latent infection and leads to pathogenic expression in the nervous system. We also study other herpes viruses
This virus, discovered over half a century ago, does not even have an established infection system. This 3.2kb DNA virus uses only four genetic products to persistently infect the liver. Furthermore, it also has a reverse transcription process in its life cycle, similar to a retrovirus. Our research aims to reveal the true life cycle of this virus, and to uncover the mechanism of disease development and treatment strategies.
