The 20th International Symposium on Molecular and Neural Mechanisms
of Taste and Olfactory Perception (ISMNTOP2023, YRUF2023, AISCRIB2023)
November 25-26, 2023, @ Okayama University

 Hosted by:
   Department of oral physiology, Faculty of medicine, dentistry and pharmaceutical sciences, Okayama University

   Yuzo Ninomiya (Okayama Univ, Kyushu Univ, Monell Chemical Senses Center)

   Ryusuke Yoshida (Okayama Univ)


----- November 25th, Saturday ----

■ Opening remarks: 12:50 - 13:00

Ryusuke Yoshida (Okayama Univ)

■ Session 1: Memorial session for Dr. Kunio Torii: 13:00 – 15:20

IS1-1: 13:00 - 13:10
Yuzo Ninomiya (Okayama Univ, Kyushu Univ, Monell Chemical Senses Center)

IS1-2: 13:10 - 13:35
Gut Umami Sensing Hypothesis:A Short History and Perspectives
Hisayuki Uneyama (Ajinomoto Co.)

IS1-3: 13:35 - 14:00
Umami: the long journey of the 5th basic taste
Ana San Gabriel (Ajinomoto Co.)

IS1-4: 14:00 - 14:25
Turning of umami research: shift from defense (safety) to offense (physiological significance)
Takashi Kondoh (Kindai University)

IS1-5: 14:25 - 14:50
Studies of endoderm-derived chemosensory cells using organoid culture system
Ken Iwatsuki (Tokyo University of Agriculture)

IS1-6: 14:50 - 15:20 (special talk)
L-ornithine and GPRC6A may be a novel kokumi substance and a kokumi receptor
Takashi Yamamoto (Kio University)

BREAK: 15:20 - 15:40

■ Session 2: Taste Receptor: 15:40 – 16:55

IS2-1: 15:40 - 16:05
Unique preference for the specific foods in primate species based on the molecular properties of receptors
Hiroo Imai (Kyoto University)

IS2-2: 16:05 - 16:30
Chemical range recognized by the ligand-binding domain of medaka T1r2a/T1r3
Atsuko Yamashita (Okayama University)

IS2-3: 16:30 - 16:55
Elucidation for the activation/inactivation dynamics of the sweet taste receptor
Keisuke Sanematsu (Kyushu University)

■ Poster session 1: 16:55 – 18:15

■ Bus transportation: 18:30

■ Short Talk Session and Social Gathering: 19:00 – 21:00

----- November 26th, Sunday ----

■ Session 3: Olfaction: 9:00 – 10:40

IS3-1: 9:00 - 9:25
Antagonistic interactions between odorants influence human odor perception.
Yosuke Fukutani (Tokyo University of Agriculture and Technology)

IS3-2: 9:25 - 9:50
Contribution of RNA binding proteins in axon targeting and maturation of olfactory sensory neurons
Nanaho Fukuda (Niigata University)

IS3-3: 9:50 - 10:15
Mechanisms of synaptic competition for establishing the “one mitral cell – one glomerulus” connection rule
Satoshi Fujimoto (Kyushu University)

IS3-4: 10:15 - 10:40
Neuronal migration depends on blood flow in the adult olfactory bulb
Takashi Ogino (Nagoya City University)

BREAK: 10:40 - 11:00

■ Special lecture 1: 11:00 – 11:40

How do mammalian odorant receptors recognize odorants?
Hiroaki Matsunami (Duke University School of Medicine, USA)

LUNCH and BREAK: 11:40 - 12:40

■ Special lecture 2: 12:40 – 13:20

How Sweet it is: Metabolic and Hedonic Aspects of Oral Sugar Sensing
Lindsey Schier (University of Southern California, USA)

BREAK: 13:20 - 13:30

■ Session 4: The 11th Asian International Symposium on Chemo-Reception and Ingestive Behavior 2023 (AISCRIB2023): 13:30 – 15:20

IS4-1: 13:30 - 14:00 (special talk)
The Function of Glial Odorant Receptors in Neuroinflammation
JaeHyung Koo (DGIST, Korea)

IS4-2: 14:00 - 14:30 (special talk)
The circuit mechanism that links brain sugar-sensing to peripheral nociceptive gating in Drosophila
Kazuo Emoto (University of Tokyo)

IS4-3: 14:30 - 14:55
Role of the central nucleus of the amygdala in behavioral expression on retrieval of conditioned taste aversion memory
Tadashi Inui (Hokkaido University)

IS4-4: 14:55 - 15:20
SNAP-25 contributes to the maintenance of Type III taste receptor cells
Kengo Horie (Okayama University)

BREAK: 15:20 - 15:30

■ Session 5: Transporters, ion channels and GPCRs involved in chemosensory signaling: 15:30 – 16:45

IS5-1: 15:30 - 15:55
Warm-activated TRP channels regulate oral epithelial regeneration
Reiko Yoshimoto (Saga University)

IS5-2: 15:55 - 16:20
Impaired Pheromone Perception and Abnormal Sexual Behavior in ancV1R Deficient Female Mice
Hiro Kondo (Tokyo Institute of Technology)

IS5-3: 16:20 - 16:45
The effect of single nucleotide polymorphisms of GPR120 on detection threshold, liking and fattiness ratings of oleic acid
Keiko Yasumatsu (Tokyo Dental Junior College)

■ Closing remarks 16:45-

Masahiro Yamaguchi (Kochi Univ)

■ Poster session

Combinatorial orthosteric and allosteric interactions of an odorant receptor
Shigenori Inagaki (Kyushu Univ)

Submodalities of intestinal chemical senses studied with in vivo Ca2+ imaging of the nodose petrosal ganglia neurons
Hikari Takeshima (Kyushu Univ)

An attempt to understand the molecular mechanism underlying toothpaste-mediated taste-modification
Chiaki Taketani (Kao Corp)

Identification of Cibacron Blue 3G-A as an inhibitor of Otopetrin 1 (OTOP1), a sour sensing proton channel
MD Mominul Islam (Hokkaido Univ)

Correlation between the functional polymorphisms in TAS2Rs and human bitter taste perception for caffeine
Rena Numabe (Kyoto Univ)

Enantiomers of organic acids are identified by the preference taste receptors Tas1R2/Tas1R3 or Tas1R1/Tas1R3
Yuko Yamase (Okayama Univ)

Ligand-binding analysis of the ligand-binding domain of taste receptor T1r2a/T1r3 from medaka fish
Hikaru Ishida (Okayama Univ)

Chemosensory studies using organoids: from monkey to human
Shinsuke Matsui (Tokyo Univ Agri)

Ccn3 expression in the murine taste bud does not confer essential roles in taste perception
Kuanyu Wang (Okayama Univ)

The neural mechanism regulating psychological stress-induced sweet taste modification
Mayui Tanaka (Univ Tokyo)

The effect of fatty acids and involvement of GPR120 on sweet taste in mouse chorda tympani nerve
Kasumi Hata (Tokyo Dent College)

Hormonal effects on the salt preference in the dietary zinc-deficient female rat
Chizuko Inui-Yamamoto (Osaka Univ)

Enhancement of umami taste by Na ion in humans
Kana Tanaka (Kindai Univ)

Enhancement of sweet taste by NaCl in humans
Takashi Kondoh (Kindai Univ)

The Oral Metabolic Signaling Pathway for the Polyol Sweeteners Sorbitol, Allulose, and Erythritol is inhibited by Phlorizin
Tadahiro Ohkuri (Suntory Beverage Food)

Capsaicin enhances the mouse chorda tympani nerve responses to sugars and salt
Shusuke Iwata (Asahi Univ)

Lick rates, number of taste buds and mRNA expression levels of taste-related molecules during vitamin B2 deficiency
Toshiaki Yasuo (Asahi Univ)