Intellectual Property and Enterprise

Type 2 diabetes drug, metformin, re-activates immune-exhausted tumor infiltrating CD8T lymphocyte in tumor microenvironment and confers significant anti-tumor immunity

Anti-cancer effect of tumor infiltrating CD8+T lymphocyte (CD8TIL) is suppressed by interaction between immune-checkpoint molecules such as PD-1 and CTLA-4 expressed on CD8TIL and their ligands expressed on...