2024
Yuta Iijima, Ryohei Miki, Nobumasa Takasugi, Masatake Fujimura, Takashi Uehara.: Characterization of pathological changes in the olfactory system of mice exposed to methylmercury. Archives of Toxicology. 2024 Feb 17. doi: 10.1007/s00204-024-03682-w.
Yuta Iijima, Ryohei Miki, Masatake Fujimura, Seiichi Oyadomari, Takashi Uehara.: Methylmercury-induced brain neuronal death in CHOP-knockout mice. The Journal of Toxicological Sciences. 2024. doi: 10.2131/jts.49.55.
Masato Komai, Yuka Noda, Atsuya Ikeda, Nanaka Kaneshiro, Yuji Kamikubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi.: Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes. Journal of Lipid Research. 2024 Jan 25. doi: 10.1016/j.jlr.2024.100510.
Atsushi Morimoto, Nobumasa Takasugi, Yuexuan Pan, Sho Kubota, Naoshi Dohmae, Yumi Abiko, Koji Uchida, Yoshito Kumagai, and Takashi Uehara.: Methyl vinyl ketone and its analogs covalently modify PI3K and alter physiological functions by inhibiting PI3K signaling. J Biol Chem 2024 Jan 24. doi: 10.1016/j.jbc.2024.105679
Rikako Taniguchi, Yuto Moriya, Naoshi Dohmae, Takehiro Suzuki, Kengo Nakahara, Sho Kubota, Nobumasa Takasugi, Takashi Uehara.: Attenuation of protein arginine dimethylation via S-nitrosylation of protein arginine methyltransferase 1. J Pharmacol Sci 2024 Feb 6. doi: 10.1016/j.jphs.2023.12.012
2023
Kosaku Okuda, Kengo Nakahara, Akihiro Ito, Yuta Iijima, Ryosuke Nomura, Ashutosh Kumar, Kana Fujikawa, Kazuya Adachi, Yuki Shimada, Satoshi Fujio, Reina Yamamoto, Nobumasa Takasugi, Kunishige Onuma, Mitsuhiko Osaki, Futoshi Okada, Taichi Ukegawa, Yasuo Takeuchi, Norihisa Yasui, Atsuko Yamashita, Hiroyuki Marusawa, Yosuke Matsushita, Toyomasa Katagiri, Takahiro Shibata, Koji Uchida, Sheng-Yong Niu, Nhi B Lang, Tomohiro Nakamura, Kam Y J Zhang, Stuart A Lipton, Takashi Uehara. Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis. Nat Commun. 2023 Feb 4;14(1):621. doi: 10.1038/s41467-023-36232-6. PMID: 36739439
Nobumasa Takasugi, Masato Komai, Nanaka Kaneshiro, Atsuya Ikeda, Yuji Kamikubo, Takashi Uehara. The Pursuit of the "Inside" of the Amyloid Hypothesis-Is C99 a Promising Therapeutic Target for Alzheimer's Disease? Cells. 2023 Jan 31;12(3):454. doi: 10.3390/cells12030454. PMID: 36766796
2022
Ryosuke Nomura, Nobumasa Takasugi, Hideki Hiraoka, Yuta Iijima, Takao Iwawaki, Yoshito Kumagai, Masatake Fujimura, Takashi Uehara.: Alterations in UPR Signaling by Methylmercury Trigger Neuronal Cell Death in the Mouse Brain. Int J Mol Sci. 2022 Dec 6;23(23):15412. doi: 10.3390/ijms232315412. PMID: 36499738
Nanaka Kaneshiro, Masato Komai, Ryosuke Imaoka, Atsuya Ikeda, Yuji Kamikubo, Takashi Saito, Takaomi C. Saido, Taisuke Tomita, Tadafumi Hashimoto, Takeshi Iwatsubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi.: Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease. iScience.2022 Mar 18;100524. doi:10.1016/j.isci.2022.103869. PMID: 35243232
2021
Nakahara K, Hamada K, Tsuchida T, Takasugi N, Abiko Y, Shien K, Toyooka S, Kumagai Y, Uehara T.: Covalent N-arylation by the pollutant 1,2-naphthoquinone activates the EGF receptor. J Biol Chem.2021 Mar 8;100524. doi: 10.1016/j.jbc.2021.100524. Online ahead of print. PMID: 33705793
Hiraoka H, Nomura R, Takasugi N, Akai R, Iwawaki T, Kumagai Y, Fujimura M, Uehara T.: Spatiotemporal analysis of the UPR transition induced by methylmercury in the mouse brain. Archives of Toxicolgy. 2021 Jan 16. doi: 10.1007/s00204-021-02982-9. Online ahead of print. PMID: 33454823
2020
S-Nitrosylation at the active site decreases the ubiquitin-conjugating activity of ubiquitin-conjugating enzyme E2 D1 (UBE2D1), an ERAD-associated protein.Biochem Biophys Res Commun. 2020 Feb 10. pii: S0006-291X(20)30271-0. doi: 10.1016/j.bbrc.2020.02.011.
2019
Nakahara K, Fujikawa K, Hiraoka H, Miyazaki I, Asanuma M, Ito A, Takasugi N, Uehara T.: Attenuation of Macrophage Migration Inhibitory Factor-Stimulated Signaling via S-Nitrosylation. Biol Pharm Bull.2019;42(6):1044-1047. doi: 10.1248/bpb.b19-00025. PMID: 31155581
Takasugi N, Hiraoka H, Nakahara K, Akiyama S, Fujikawa K, Nomura R, Furuichi M, Uehara T.: The Emerging Role of Electrophiles as a Key Regulator for Endoplasmic Reticulum (ER) Stress. Int J Mol Sci. 2019 Apr 10;20(7). pii: E1783. doi: 10.3390/ijms20071783. PMID: 30974903 (review)
2018
Kaneshiro N, Imaoka R, Komai M, Kashiyama T, Sakurai T, Uehara T, Takasugi N.: Functional analysis of juxta- and intra-membrane domains of murine APP by genome editing in Neuro2a cells. Biochem Biophys Res Commun. 2018 Jul 2;501(4):1023-1028. doi: 10.1016/j.bbrc.2018.05.102. Epub 2018 May 23. PMID: 29777707
2017
Hiraoka H, Nakahara K, Kaneko Y, Akiyama S, Okuda K, Iwawaki T, Fujimura M, Kumagai Y, Takasugi N, Uehara T.: Modulation of Unfolded Protein Response by Methylmercury. Biol Pharm Bull.2017;40(9):1595-1598. doi: 10.1248/bpb.b17-00359. PMID: 28867746
Abiko Y, Shinkai Y, Unoki T, Hirose R, Uehara T, Kumagai Y.: Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts. Sci Rep. 2017 Jul 6;7(1):4814. doi: 10.1038/s41598-017-04590-z. PMID: 28684787
2016
Nakato R, Ohkubo Y, Konishi A, Shibata M, Kaneko Y, Iwawaki T, Nakamura T, Lipton SA, Uehara T.: Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress. Sci Rep. 2015 Oct 8;5:14812. doi: 10.1038/srep14812. PMID: 26446798
2015
Ohno K, Okuda K, Uehara T.: Endogenous S-sulfhydration of PTEN helps protect against modification by nitric oxide. Biochem Biophys Res Commun. 2015 Jan 2;456(1):245-9. doi: 10.1016/j.bbrc.2014.11.066. Epub 2014 Nov 24.PMID: 25446078
Makino K, Okuda K, Sugino E, Nishiya T, Toyama T, Iwawaki T, Fujimura M, Kumagai Y, Uehara T.: Correlation between attenuation of protein disulfide isomerase activity through S-mercuration and neurotoxicity induced by methylmercury. Neurotox Res. 2015 Feb;27(2):99-105. doi: 10.1007/s12640-014-9494-8. Epub 2014 Oct 7. PMID: 25288108
~2014
Uehara T, Nishiya T.: Screening systems for the identification of S-nitrosylated proteins.
Nitric Oxide. 2011 Aug 1;25(2):108-11. doi: 10.1016/j.niox.2010.11.002. Epub 2010 Nov 24. PMID: 21111056
Uehara T, Nakamura T, Yao D, Shi ZQ, Gu Z, Ma Y, Masliah E, Nomura Y, Lipton SA.: S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature. 2006 May 25;441(7092):513-7. doi: 10.1038/nature04782.
PMID: 16724068
Tsuruma K, Nakagawa T, Morimoto N, Minami M, Hara H, Uehara T, Nomura Y.: Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury. J Biol Chem. 2006 Apr 21;281(16):11397-404. doi: 10.1074/jbc.M510597200. Epub 2006 Feb 23.
PMID: 16497673
Lipton SA, Nakamura T, Yao D, Shi ZQ, Uehara T, Gu Z.: Comment on “S-nitrosylation of parkin regulates ubiquitination and compromises parkin’s protective function”.
Science. 2005 Jun 24;308(5730):1870; author reply 1870. doi: 10.1126/science.1110135. PMID: 15976289
Ogino S, Tsuruma K, Uehara T, Nomura Y.: Herbimycin A abrogates nuclear factor-kappaB activation by interacting preferentially with the IkappaB kinase beta subunit.
Mol Pharmacol. 2004 Jun;65(6):1344-51. doi: 10.1124/mol.65.6.1344. PMID: 15155828
Furuta Y, Uehara T, Nomura Y.: Correlation between delayed neuronal cell death and selective decrease in phosphatidylinositol 4-kinase expression in the CA1 subfield of the hippocampus after transient forebrain ischemia. J Cereb Blood Flow Metab. 2003 Aug;23(8):962-71. doi: 10.1097/01.WCB.0000073948.29308.F8. PMID: 12902840
Ko HS, Uehara T, Nomura Y.: Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death.
J Biol Chem. 2002 Sep 20;277(38):35386-92. doi: 10.1074/jbc.M203412200. Epub 2002 Jul 2. PMID: 12095988
Tanaka S, Uehara T, Nomura Y.: Up-regulation of protein-disulfide isomerase in response to hypoxia/brain ischemia and its protective effect against apoptotic cell death.
J Biol Chem. 2000 Apr 7;275(14):10388-93. doi: 10.1074/jbc.275.14.10388. PMID: 10744727
Uehara T, Matsuno J, Kaneko M, Nishiya T, Fujimuro M, Yokosawa H, Nomura Y.: Transient nuclear factor kappaB (NF-kappaB) activation stimulated by interleukin-1beta may be partly dependent on proteasome activity, but not phosphorylation and ubiquitination of the IkappaBalpha molecule, in C6 glioma cells. Regulation of NF-kappaB linked to chemokine production. J Biol Chem. 1999 May 28;274(22):15875-82. doi: 10.1074/jbc.274.22.15875. PMID: 10336492