2020年

Tsuchiya H, Endoh F, Akiyama T, Matsuhashi M, Kobayashi K.
Longitudinal correspondence of epilepsy and scalp EEG fast (40-200 Hz) oscillations in pediatric patients with tuberous sclerosis complex.
Brain Dev, in press.

Miyata H, Fushimi S, Ota Y, Vinters HV, Adachi K, Nanba E, Akiyama T.
Isolated cortical tuber in an infant with genetically confirmed tuberous sclerosis complex 1 presenting with symptomatic West syndrome.
Neuropathology, in press.

Shibata T, Otsubo H.
Phase-amplitude coupling of delta brush unveiling neuronal modulation development in the neonatal brain.
Neurosci Lett 2020; 735: 135211.

Furui A, Onishi R, Takeuchi A, Akiyama T, Tsuji T.
Non-Gaussianity detection of EEG signals based on a multivariate scale mixture model for diagnosis of epileptic seizures.
IEEE Biomed Trans Eng, in press.

Kuhara T, Akiyama T, Ohse M, Koike T, Shibasaki J, Imai K, Cooper AJL.
Identification of new biomarkers of pyridoxine-dependent epilepsy by GC/MS-based urine metabolomics.
Anal Biochem, in press. PMID: 32339489

Akiyama T, Toda S, Kimura N, Mogami Y, Hanaoka Y, Tokorodani C, Ito T, Miyahara H, Hyodo Y, Kobayashi K.
Vitamin B6 in acute encephalopathy with biphasic seizures and late reduced diffusion.
Brain Dev 2020; 42: 402-407. PMID: 32107100

Miyahara H, Akiyama T, Hasegawa K, Akiyama M, Oka M, Kobayashi K, Tsukahara H.
Laboratory changes during ACTH therapy associated with renal calcified lesions.
Pediatr Int, in press. PMID: 31957090

Din F, Lalgudi Ganesan S, Akiyama T, Stewart CP, Ochi A, Otsubo H, Go C, Hahn CD.
Seizure detection algorithms in critically ill children: A comparative evaluation.
Crit Care Med, in press. PMID: 31876526

Koyama H, Yasuda S, Kakoi S, Ohata Y, Shimizu Y, Hasegawa C, Hayakawa A, Akiyama T, Yagi T, Aotani D, Imaeda K, Ozono K, Kataoka H, Tanaka T.
Effect of Asfotase Alfa on muscle weakness in a Japanese adult patient of hypophosphatasia with Low ALP levels.
Internal Med 2020; 59: 811-815. PMID: 31787692

Akiyama T, Saigusa D, Hyodo Y, Umeda K, Saijo R, Koshiba S, Kobayashi K.
Metabolic profiling of the cerebrospinal fluid in pediatric epilepsy.
Acta Med Okayama 2020; 74: 65-71. PMID: 32099251

Okanari K, Maruyama S, Suzuki H, Shibata T, Pulcine E, Donner EJ, Otsubo H.
Autonomic dysregulation in children with epilepsy with postictal generalized EEG suppression following generalized convulsive seizures.
Epilepsy Behav 2020; 102: 106688. PMID: 31805503

Kobayashi K, Endoh F, Ohmori I, Akiyama T.
Action of antiepileptic drugs on neurons.
Brain Dev 2020; 42: 2-5. PMID: 31351738

2019年

Yanagishita T, Yamamoto-Shimojima K, Koike T, Nasu H, Takahashi Y, Akiyama T, Nagata S, Yamamoto T.
Compound heterozygous ALDH7A1 mutation causes the hemi-allelic expression in a patient with pyridoxine-dependent epilepsy.
Tokyo Women's Med Univ J 2019; 3: 73-77. Journal website

Yokoi K, Nakajima Y, Shinkai Y, Sano Y, Imamura M, Akiyama T, Yoshikawa T, Ito T, Kurahashi H.
Clinical and genetic aspects of mild hypophosphatasia in Japanese patients.
Mol Genet Metab Rep 2019; 21: 100515. PMID: 31641588

Ohuchi Y, Akiyama T, Matsuhashi M, Kobayashi K.
High-frequency oscillations in a spectrum of pediatric epilepsies characterized by sleep-activated spikes in scalp EEG.
Clin Neurophysiol 2019; 130: 1971-1980. PMID: 31476703

Momosaki K, Kido J, Matsumoto S, Taniguchi A, Akiyama T, Sawada T, Ozasa S, Nakamura K.
The effect of S-adenosylmethionine treatment on neurobehavioral phenotypes in Lesch-Nyhan disease: a case report.
Case Rep Neurol 2019; 11: 256-264. PMID: 31607891

Yamamoto T, Imaizumi T, Yamamoto-Shimojima K, Lu Y, Yanagishita T, Shimada S, Chong PF, Kira R, Ueda R, Ishiyama A, Takeshita E, Momosaki K, Ozasa S, Akiyama T, Kobayashi K, Oomatsu H, Kitahara H, Yamaguchi T, Imai K, Kurahashi H, Okumura A, Oguni H, Seto T, Okamoto N.
Genomic backgrounds of Japanese patients with undiagnosed neurodevelopmental disorders.
Brain Dev 2019; 41: 776-782. PMID: 31171384

Ishiguro T, Sugiyama Y, Ueda K, Muramatsu Y, Tsuda H, Kotani T, Michigami T, Tachikawa K, Akiyama T, Hayakawa M.
Findings of amplitude-integrated electroencephalogram recordings and serum vitamin B6 metabolites in perinatal lethal hypophosphatasia during enzyme replacement therapy.
Brain Dev 2019; 41: 721-725. PMID: 31000369

Takeuchi A, Yorifuji T, Hattori M, Tamai K, Nakamura K, Nakamura M, Kageyama M, Kubo T, Ogino T, Kobayashi K, Doi H.
Catch-up growth and behavioral development among preterm, small-for-gestational-age children: a nationwide Japanese population-based study.
Brain Dev 2019; 41: 397-405. PMID: 30611596

Tsuchiya H, Akiyama T, Kuhara T, Nakajima Y, Ohse M, Kurahashi H, Kato T, Maeda Y, Yoshinaga H, Kobayashi K.
A case of dihydropyrimidinase deficiency incidentally detected by urine metabolome analysis.
Brain Dev 2019; 41: 280-284. PMID: 30384990

2018年

Shibata K, Kobayashi K.
Epileptic high-frequency oscillations in scalp electroehcephalography.
Acta Med Okayama 2018; 72: 325-329. PMID: 30140078

Akiyama T, Kubota T, Ozono K, Michigami T, Kobayashi D, Takeyari S, Sugihara Y, Noda M, Harada D, Namba N, Suzuki A, Utoyama M, Kitanaka S, Uematsu M, Mitani Y, Matsunami K, Takishima S, Ogawa E, Kobayashi K.
Pyridoxal 5'-phosphate and related metabolites in hypophosphatasia: effects of enzyme replacement therapy.
Mol Genet Metab 2018; 125: 174-180. PMID: 30049651

Miyahara H, Akiyama T, Waki K, Arakaki Y.
Differential diagnosis of nonepileptic twilight state with convulsive manifestations after febrile seizures.
Brain Dev 2018; 40: 781-785. PMID: 29866486

Oyachi M, Harada D, Sakamoto N, Ueyama K, Kondo K, Kishimoto K, Izui M, Nagamatsu Y, Kashiwagi H, Yamamuro M, Tamura M, Kikuchi S, Akiyama T, Michigami T, Seino Y, Namba N.
A case of perinatal hypophosphatasia with a novel mutation in the ALPL gene: clinical course and review of the literature.
Clin Pediatr Endocrinol 2018; 27: 179-186. PMID: 30083035

Takeuchi A, Koeda T, Ogino T, Oka M, Yorifuji T, Takayanagi T, Sato K, Sugino N, Bonno M, Nakamura M, Kageyama M.
Intelligence test at preschool-age predicts reading difficulty among school-aged very low birth weight infants in Japan.
Brain Dev 2018; 40: 735-742. PMID: 29793755

Kobayashi K, Ohuchi Y, Shibata T, Hanaoka Y, Akiyama M, Oka M, Endoh F, Akiyama T.
Detection of fast (40-150 Hz) oscillations from the ictal scalp EEG data of myoclonic seizures in pediatric patients.
Brain Dev 2018; 40: 397-405. PMID: 29395662

Iimura Y, Jones K, Takada L, Shimizu I, Koyama M, Hattori K, Okazawa Y, Nonoda Y, Asano E, Akiyama T, Go C, Ochi A, Snead OC 3rd, Donner EJ, Rutka JT, Drake JM, Otsubo H.
Strong coupling between slow oscillations and wide fast ripples in children with epileptic spasms: Investigation of modulation index and occurrence rate.
Epilepsia 2018; 50: 544-554. PMID: 29315516

Takeuchi A, Yorifuji T, Nakamura K, Tamai K, Mori S, Nakamura M, Kageyama M, Kubo T, Ogino T, Kobayashi K, Doi H.
Catch-up growth and neurobehavioral development among full term, small-for-gestational-age children: a nationwide Japanese population-based study.
J Pediatr 2018; 192: 41-46. PMID: 29092752

2017年

Frauscher B, Bartolomei F, Kobayashi K, Cimbalnik J, van't Klooster MA, Rampp S, Otsubo H, Holler Y, Wu JY, Asano E, Engel J Jr, Kahane P, Jacobs J, Gotman J.
High-frequency oscillations: The state of clinical research.
Epilepsia 2017; 58: 1316-1329. PMID: 28666056

Akiyama T, Hayashi Y, Hanaoka Y, Shibata T, Akiyama M, Tsuchiya H, Yamaguchi T, Kobayashi K.
Pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid in the paired serum and cerebrospinal fluid of children.
Clin Chim Acta 2017; 472: 118-122. PMID: 28778380

Shibata T, Kobayashi K, Yoshinaga H, Ono H, Shinpo M, Kagitani-Shimono K.
Another case of glucose transporter 1 deficiency syndrome with periventricular calcification, cataracts, hemolysis, and pseudohyperkalemia.
Neuropediatrics 2017; 48: 390-393. PMID: 28582795

Kobayashi K, Akiyama T, Agari T, Sasaki T, Shibata T, Hanaoka Y, Akiyama M, Endoh F, Oka M, Date I.
Significance of high-frequency electrical brain activity.
Acta Med Okayama 2017; 71: 191-200. PMID: 28655938

Iimura Y, Jones K, Hattori K, Okazawa Y, Noda A, Hoashi K, Nonoda Y, Asano E, Akiyama T, Go C, Ochi A, Snead OC III, Donner EJ, Rutka JT, Drake JM, Otsubo H.
The epileptogenic high frequency oscillations skipping the motor area in children with multilobar drug-resistant epilepsy.
Clin Neurophysiol 2017; 128: 1197-1205. PMID: 28521267

Kobayashi K, Endoh F, Agari T, Akiyama T, Akiyama M, Hayashi Y, Shibata T, Hanaoka Y, Oka M, Yoshinaga H, Date I.
Complex observation of scalp fast (40-150 Hz) oscillations in West syndrome and related disorders with structural brain pathology.
Epilepsia Open 2017; 2: 260-266. PMID: 29588955

Hanaoka Y, Yoshinaga H, Kobayashi K.
A ten-year follow-up cohort study of childhood epilepsy: changes in epilepsy diagnosis with age.
Brain Dev 2017; 39: 312-320. PMID: 27847129

Akiyama T, Akiyama M, Hayashi Y, Shibata T, Hanaoka Y, Toda S, Imai K, Hamano S, Okanishi T, Yoshinaga H, Kobayashi K.
Measurement of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid in the cerebrospinal fluid of children.
Clin Chim Acta 2017; 466: 1-5. PMID: 28040557

Kobayashi Y, Tohyama J, Akiyama T, Magara S, Kawashima H, Akasaka N, Nakashima M, Saitsu H, Matsumoto N.
Severe leukoencephalopathy with cortical involvement and peripheral neuropathy due to FOLR1 deficiency.
Brain Dev 2017; 39: 266-270. PMID: 27743887

Ogino T, Hanafusa K, Morooka T, Takeuchi A, Oka M, Ohtsuka Y.
Predicting the reading skill of Japanese children.
Brain Dev 2017; 39: 112-121. PMID: 27637722

Takeuchi A, Yorifuji T, Takahashi K, Nakamura M, Kageyama M, Kubo T, Ogino T, Kobayashi K, Doi H.
Behavioral outcomes of school-aged full-term small-for-gestational-age infants: a nationwide Japanese population-based study.
Brain Dev 2017; 39: 101-106. PMID: 27622852

Akiyama T, Hayashi Y, Hanaoka Y, Shibata T, Akiyama M, Nakamura K, Tsuyusaki Y, Kubota M, Yoshinaga H, Kobayashi K.
Simultaneous measurement of monoamine metabolites and 5-methyltetrahydrofolate in the cerebrospinal fluid of children.
Clin Chim Acta 2017; 465: 5-10. PMID: 27940130

Kobayashi Y, Hanaoka Y, Akiyama T, Ohmori I, Ouchida M, Yamamoto T, Oka M, Yoshinaga H, Kobayashi K.
A case of Dravet syndrome with cortical myoclonus indicated by jerk-locked back-averaging of electroencephalogram data.
Brain Dev 2017; 39:75-79. PMID: 27523882

Akiyama T, Shibata T, Yoshinaga H, Kuhara T, Nakajima Y, Kato T, Maeda Y, Ohse M, Oka M, Kageyama M, Kobayashi K.
A Japanese case of β-ureidopropionase deficiency with dysmorphic features.
Brain Dev 2017; 39: 58-61. PMID: 27553092

2016年

Okanishi T, Akiyama T, Mayo E, Honda Y, Ueda-Kawada C, Nakajima M, Homma Y, Ochi A, Go C, Widjaja E, Chuang SH, Rutka JT, Drake J, Snead OC III, Otsubo H.
Magnetoencephalography spike sources interrelate the extensive epileptogenic zone of tuberous sclerosis complex.
Epilepsy Res 2016; 127: 302-10. PMID: 27693986

Pal DK, Ferrie C, Addis L, Akiyama T, Capovilla G, Caraballo R, de Saint-Martin A, Fejerman N, Guerrini R, Hamandi K, Helbig I, Ioannides AA, Kobayashi K, Lal D, Lesca G, Muhle H, Neubauer BA, Pisano T, Rudolf G, Seegmuller C, Shibata T, Smith A, Striano P, Strug LJ, Szepetowski P, Valeta T, Yoshinaga H, Koutroumanidis M.
Idiopathic focal epilepsies: the "lost tribe".
Epileptic Disord 2016; 18: 252-88. PMID: 27435520

Shibata T, Yoshinaga H, Akiyama T, Kobayashi K.
A study on spike focus-dependence of high-frequency activity in idiopathic focal epilepsy in childhood.
Epilepsia Open 2016; 1: 121-129. PMID: 29588935

Akiyama M, Akiyama T, Kanamaru K, Kuribayashi M, Tada H, Shiokawa T, Toda S, Imai K, Kobayashi Y, Tohyama J, Sakakibara T, Yoshinaga H, Kobayashi K.
Determination of CSF 5-methyltetrahydrofolate in children and its application for defects of folate transport and metabolism.
Clin Chim Acta 2016; 460: 120-5. PMID: 27363740

Kobayashi K, Akiyama T, Oka M, Endoh H, Yoshinaga H.
Fast (40-150 Hz) oscillations are associated with positive slow waves in the ictal EEGs of epileptic spasms in West syndrome.
Brain Dev 2016; 38: 909-14. PMID: 27259671

Akiyama T, Miyahara H, Waki K, Yoshinaga H, Kobayashi K.
A Japanese case of hereditary chin trembling responsive to arotinolol.
Parkinsonism Relat Disord 2016; 29: 133-4. PMID: 27117562

Akiyama T, Osaka H, Shimbo H, Kuhara T, Shibata T, Kobayashi K, Kurosawa K, Yoshinaga H.
SSADH deficiency possibly associated with enzyme activity-reducing SNPs.
Brain Dev 2016; 38: 871-4. PMID: 27056292

Oka M, Shimojima K, Yamamoto T, Hanaoka Y, Sato S, Yasuhara T, Yoshinaga H, Kobayashi K.
A novel HYLS1 homozygous mutation in living siblings with Joubert syndrome.
Clin Genet 2016; 89: 739-43. PMID: 26830932

Hayashi Y, Yoshinaga H, Akiyama T, Endoh F, Ohtsuka Y, Kobayashi K.
Predictive factors for relapse of epileptic spasms after adrenocorticotropic hormone therapy in West syndrome.
Brain Dev 2016; 38: 32-9. PMID: 26547521

2015年

Yamamoto T, Shimojima K, Shibata T, Akiyama M, Oka M, Akiyama T, Yoshinaga H, Kobayashi K.
Novel PLA2G6 mutations associated with an exonic deletion derived from non-allelic homologous recombination in a patient with infantile neuroaxonal dystrophy.
Hum Genome Var 2015; 2: 15048.

Akiyama T, Tada H, Shiokawa T, Kobayashi K, Yoshinaga H.
Total folate and 5-methyltetrahydrofolate in the cerebrospinal fluid of children: correlation and reference values.
Clin Chem Lab Med 2015; 53: 2009-14.

Akiyama T, Akiyama M, Kobayashi K, Okanishi T, Boelman CG, Nita DA, Ochi A, Go CY, Snead OC III, Rutka JT, Drake JM, Chuang S, Otsubo H.
Spatial relationship between fast and slow components of ictal activities and interictal epileptiform discharges in epileptic spasms.
Clin Neurophysiol 2015; 126: 1684-91.

Nakajiri T, Kobayashi K, Okamoto N, Oka M, Miya F, Kosaki K, Yoshinaga H.
Late-onset epileptic spasms in a female patient with a CASK mutation.
Brain Dev 2015; 37: 919-23.

Takeuchi A, Okamoto N, Fujinaga S, Morita H, Shimizu J, Akiyama T, Ninomiya S, Takanashi J, Kubo T.
Progressive brain atrophy in Schinzel-Giedion syndrome with a SETBP1 mutation.
Eur J Med Genet 2015; 58: 369-71.

Akiyama T, Yamamoto T.
Epilepsy and other symptoms associated with chromosome 9q34.11 microdeletion.
J Pediatr Epilepsy 2015; 4: 23-9.

Kobayashi K, Yorifuji T, Yamakawa M, Oka M, Inoue S, Yoshinaga H, Doi H.
Poor toddler-age sleep schedules predict school-age behavioral disorders in a longitudinal survey.
Brain Dev 2015; 37: 572-8.

Kobayashi K, Yunoki K, Zensho K, Akiyama T, Oka M, Yoshinaga H.
Trend figures assist with untrained emergency electroencephalogram interpretation.
Brain Dev 2015; 37: 487-94.

Nosaka N, Ichiba S, Tsukahara K, Knaup E, Hayashi K, Kasahara S, Kobayashi Y, Oka M, Kobayashi K, Yoshinaga H, Ujike Y.
Acute respiratory distress syndrome in a child with severe epileptic disorder treated successfully by extracorporeal membrane oxygenation: a case report.
BMC Pediatr 2015; 15: 29.

Kobayashi K, Akiyama T, Ohmori I, Yoshinaga H, Gotman J.
Action potentials contribute to epileptic high-frequency oscillations recorded with electrodes remote from neurons.
Clin Neurophysiol 2015; 126: 873-81.

Yoshinaga H, Sakoda S, Shibata T, Akiyama T, Oka M, Yuan JH, Takashima H, Takahashi MP, Kitamura T, Murakami N, Kobayashi K.
Phenotypic variability in childhood of skeletal muscle sodium channelopathies.
Pediatr Neurol 2015; 52: 504-8.

Kobayashi K, Akiyama T, Oka M, Endoh F, Yoshinaga H.
A storm of fast (40-150Hz) oscillations during hypsarrhythmia in West syndrome.
Ann Neurol 2015; 77: 58-67.

Maeda Y, Kataoka Y, Sugaya A, Kariya S, Kobayashi K, Nishizaki K.
Steroid-dependent sensorineural hearing loss in a patient with Charcot-Marie-Tooth disease showing auditory neuropathy.
Auris Nasus Larynx 2015; 42: 249-53.

Toda Y, Kobayashi K, Hayashi Y, Inoue T, Oka M, Endo F, Yoshinaga H, Ohtsuka Y.
High-frequency EEG activity in epileptic encephalopathy with suppression-burst.
Brain Dev 2015; 37: 230-6.

Yoshinaga H, Kobayashi K, Shibata T, Inoue T, Oka M, Akiyama T.
Manifestation of both emetic seizures and sylvian seizures in the same patients with benign partial epilepsy.
Brain Dev 2015; 37: 13-17.

2014年

Ogino T, Kanafusa K, Morooka T, Takeuchi A, Oka M, Tsushima Y, Sanada S, Ohtsuka Y.
Categorical perception and reading skill: A survey of Japanese second graders.
Chugokugakuen J 2014; 13: 39-45.

Okanishi T, Akiyama T, Tanaka S, Mayo E, Mitsutake A, Boelman C, Go C, Snead OC 3rd, Drake J, Rutka J, Ochi A, Otsubo H.
Interictal fast ripples correlating with seizure outcome in patients with widespread epileptic networks in tuberous sclerosis complex.
Epilepsia 2014; 55: 1602-10.

Ibrahim GM, Wong SM, Anderson RA, Singh-Cadieux G, Akiyama T, Ochi A, Otsubo H, Okanishi T, Valiante TA, Donner E, Rutka JT, Snead OC 3rd, Doesburg SM.
Dynamic modulation of epileptic high frequency oscillations by the phase of slower cortical rhythms.
Exp Neurol 2014; 251: 30-8.

Akiyama M, Kobayashi K, Inoue T, Akiyama T, Yoshinaga H.
Five pediatric cases of ictal fear with variable outcomes.
Brain Dev 2014; 36: 758-63.

Sasaki M, Ishii A, Saito Y, Morisada N, Iijima K, Takada S, Araki A, Tanabe Y, Arai H, Yamashita S, Ohashi T, Oda Y, Ichiseki H, Hirabayashi S, Yasuhara A, Kawawaki H, Kimura S, Shimono M, Narumiya M, Suzuki M, Yoshida T, Oyazato Y, Tsuneishi S, Ozasa S, Yokochi K, Dejima S, Akiyama T, Kishi N, Kira R, Ikeda T, Oguni H, Zhang Bo, Tsuji S, Hirose S.
Genotype-phenotype correlations in alternating hemiplegia of childhood.
Neurology 2014; 82: 482-90.

Akiyama T, Kobayashi K, Higashikage A, Sato J, Yoshinaga H.
CSF/plasma ratios of amino acids: Reference data and transports in children.
Brain Dev 2014; 36: 3-9.

Akiyama T, Osaka H, Shimbo H, Nakajiri T, Kobayashi K, Oka M, Endoh F, Yoshinaga H.
A Japanese adult case of guanidinoacetate methyltransferase deficiency.
JIMD Rep 2014; 12: 65-9.
グアニジノ酢酸メチルトランスフェラーゼ欠損症（クレアチン合成障害）の本邦初症例報告
岡山大学によるプレスリリース記事
論文のダウンロードはこちら

2013年

Takeuchi A, Ogino T, Hanafusa K, Morooka T, Oka M, Yorifuji T, Ohtsuka Y.
Inhibitory function and working memory in attention deficit/hyperactivity disorder and pervasive developmental disorders: does a continuous cognitive gradient explain ADHD and PDD traits?
Acta Med Okayama 2013; 67: 293-303.

Kobayashi K, Endoh F, Ogino T, Oka M, Morooka T, Yoshinaga H, Ohtsuka Y.
Questionnaire-based assessment of behavioral problems in Japanese children with epilepsy.
Epilepsy Behav 2013; 27: 238-42.

Kobayashi K, Miya K, Akiyama T, Endoh F, Oka M, Yoshinaga H, Ohtsuka Y.
Cortical contribution to scalp EEG gamma rhythms associated with epileptic spasms.
Brain Dev 2013; 35: 762-70.

Toda Y, Kobayashi K, Hayashi Y, Inoue T, Oka M, Ohtsuka Y.
Effects of intravenous diazepam on high-frequency oscillations in EEGs with CSWS.
Brain Dev 2013; 35: 540-7.

Kobayashi K, Ohmori I, Hayashi K, Kitagawa Y, Ouchida M, Inoue T, Ohtsuka Y.
High-frequency EEG oscillations in hyperthermia-induced seizures of Scn1a mutant rats.
Epilepsy Res 2013; 103: 161-6.

Yoshinaga H, Kobayashi K, Akiyama T, Shibata T, Endoh F, Otsuka Y.
Clinical implications preceding positive spikes in patients with benign partial epilepsy and febrile seizures.
Brain Dev 2013; 35: 299-306.

Ohmori I, Ouchida M, Kobayashi K, Jitsumori Y, Mori A, Michiue H, Nishiki T, Ohtsuka Y, Matsui H.
CACNA1A variants may modify the epileptic phenotype of Dravet syndrome.
Neurobiol Dis 2013; 50: 209-17.

2012年

Akiyama M, Kobayashi K, Ohtsuka Y.
Dravet syndrome: a genetic epileptic disorder.
Acta Med Okayama 2012; 66: 369-76.

Agari T, Kobayashi K, Watanabe K, Date I, Ohtsuka Y.
Cryptogenic West syndrome and subsequent mesial temporal lobe epilepsy.
Epileptic Disord 2012; 14: 334-9.

Nakano K, Kobayashi K, Okano Y, Aso K, Ohtsuka Y.
Intractable absence seizures in hyperinsulinism-hyperammonemia syndrome.
Pediatr Neurol 2012; 47:119-22.

Ibrahim GM, Akiyama T, Ochi A, Otsubo H, Smith M, Taylor MJ, Donner EJ, Rutka JT, Snead OC III, Doesbrg SM.
Disruption of Rolandic gamma-band functional connectivity by seizures is associated with motor impairments in children with epilepsy.
PLoS One 2012; 7: e39326.

Endoh F, Kobayashi K, Hayashi Y, Shibata T, Yoshinaga H, Ohtsuka Y.
Efficacy of topiramate for intractable childhood generalized epilepsy with epileptic spasms: With special reference to electroencephalographic changes.
Seizure 2012; 21: 522-8.

Kobayashi K, Ohzono H, Shinohara M, Saitoh M, Ohmori I, Ohtsuka Y, Mizuguchi M.
Acute encephalopathy with a novel point mutation in the SCN2A gene.
Epilepsy Res 2012; 102: 109-12.

Kobayashi K, Yoshinaga H, Ohtsuka Y.
Memory enhancement and deep-brain stimulation of the entorhinal area.
N Engl J Med 2012; 366: 1945.

Ibrahim GM, Fallah A, Albert GW, Withers T, Otsubo H, Ochi A, Akiyama T, Donner EJ, Weiss S, Snead OC 3rd, Drake JM, Rutka JT.
Occipital lobe epilepsy in children: Characterization, evaluation and surgical outcomes.
Epilepsy Res 2012; 99: 335-45.

Yoshinaga H, Sakoda S, Jean-Marc G, Takahashi M, Kubota T, Arikawa-Hirasawa E, Nakata T, Ohno K, Kitamura T, Kobayashi K, Ohtsuka Y.
A novel mutation in SCN4A causes severe myotonia and school-age-onset paralytic episodes.
J Neurol Sci 2012; 315: 15-19.

Kobayashi K, Ohtsuka Y, Ohmori I. Additional information regarding "Dravet syndrome: inroads into understanding epileptic encephalopathies".
J Pediatr 2012; 160: 5.

Kobayashi K, Yoshinaga H, Ohtsuka Y.
Drug-resistant epilepsy.
N Engl J Med 2011; 365: 2238-9.

Kobayashi K, Takeuchi A, Oka M, Akiyama M, Ohtsuka Y.
Amelioration of disabling myoclonus in a case of DRPLA by levetiracetam.
Brain Dev 2012; 34: 368-71.

Akiyama T, Osada M, Isowa M, Go CY, Ochi A, Elliott IM, Akiyama M, Snead OC III, Rutka JT, Drake JM, Otsubo H.
High kurtosis of intracranial electroencephalogram as a marker of ictogenicity in pediatric epilepsy surgery.
Clin Neurophysiol 2012; 123: 93-9.

Inage Y, Halliday WC, Go CY, Ochi A, Akiyama T, Widjaja E, Otsubo H.
Histopahtology of cortex and white matter in pediatric epileptic spasms: comparison with those of partial seizures.
Brain Dev 2012; 34: 118-123.

Morooka T, Ogino T, Takeuchi A, Hanafusa K, Oka M, Ohtsuka Y.
Relationships between the color-word matching stroop task and the Go/NoGo task: toward multifaceted assenssment of attention and inhibition abilities of children.
Acta Medica Okayama 2012; 66: 377-86.

Kado Y, Sanada S, Yanagihara M, Ogino T, Ohno S, Watanabe K, Nakano K, Morooka T, Oka M, Ohtsuka Y.
Executive function in children with pervasive developmental disorder and attention deficit / hyperactivity disorder assessed by the Keio version of the Wisconsin card sorting test.
Brain Dev 2012; 34: 354-9.

Agari T, Mihara T, Baba K, Kobayashi K, Usui N, Terada K, Nakamura F, Matsuda K, Date I.
Surgical treatment of epilepsy associated with periventricular nodular heterotopia.
Acta Medica Okayama 2012; 66: 487-92.

2011年

Ohtahara S, Yamatogi Y, Ohtsuka Y.
Vitamin B6 treatment of intractable seizures.
Brain Dev 2011; 33: 783-9.

Ogino T, Takahashi Y, Hanafusa K, Watanabe K, Morooka T, Takeuchi A, Oka M, Sanada S, Ohtsuka Y.
Reading skills of Japanese second-graders.
Pediatr Int 2011; 53: 309-14.

Kobayashi K, Mimaki N, Endoh F, Inoue T, Yoshinaga H, Ohtsuka Y.
Amplitude-integrated EEG colored according to spectral edge frequency.
Epilepsy Res 2011; 96: 276-82.

Kobayashi K, Yoshinaga H, Toda Y, Inoue T, Oka M, Ohtsuka Y.
High-frequency oscillations in idiopathic partial epilepsy of childhood.
Epilepsia 2011; 52: 1812-9.

Kobayashi K, Watanabe K, Yoshinaga H, Ohtsuka Y.
Bilaterally independent epileptic spasms in a case of Aicardi syndrome.
Epileptic Disord 2011; 13: 326-30.

Kobayashi K, Ohmori I, Ohuchida M, Ohtsuka Y.
Dravet syndrome with an exceptionally good seizure outcome in two adolescents.
Epileptic Disord 2011; 13: 340-4.

Jacobs J, Kobayashi K, Gotman J.
High frequency changes during interictal spikes detected by time-frequency analysis.
Clin Neurophysiol 2011; 122: 32-42.

Nishiyama I, Ohtsuka Y, Tsuda T, Kobayashi K, Inoue H, Narahara K, Shiraga H, Kimura T, Ogawa M, Terasaki T, Ono H, Tanaka T.
An epidemiological study of children with status epilepticus in Okayama, Japan: incidence, etiologies, and outcomes.
Epilepsy Res 2011; 96: 89-95.

Akiyama T, Chan DW, Go CY, Ochi A, Elliott IM, Donner EJ, Weiss SK, Snead OC III, Rutka JT, Drake JM, Otsubo H.
Topographic movie of intracranial ictal high-frequency oscillations with seizure semiology: Epileptic network in Jacksonian seizures.
Epilepsia 2011; 52: 75-83.

Akiyama T, Donner EJ, Go CY, Ochi A, Snead OC III, Rutka JT, Otsubo H.
Focal-onset myoclonic seizures and secondary bilateral synchrony.
Epilepsy res 2011; 95: 168-172.

Akiyama T, McCoy B, Go CY, Ochi A, Elliott IM, Akiyama M, Donner EJ, Weiss SK, Snead OC III, Rutka JT, Drake JM, Otsubo H.
Focal resection of fast ripples on extra-operative intracranial EEG improves seizure outcome in pediatric epilepsy.
Epilepsia 2011; 52: 1802-11.
日本てんかん学会　JUHN AND MARY WADA奨励賞　受賞論文

McCoy B, Akiyama T, Widjaja E, Go C.
Autoimmune limbic encephalitis as an emerging paediatric condition: case report and review of the literature.
J Child Neurol 2011; 26: 218-22.

Viravan S, Go C, Ochi A, Akiyama T, Snead OC III, Otsubo H.
Jeavons syndrome existing as occipital cortex initiating generalized epilepsy.
Epilepsia 2011; 52: 1273-9.

Ochi A, Widjaja E, Hung R, To T, Nawa Y, Shima T, Go C, Akiyama T, Weiss S, Donner E, Drake J, Rutka JT, Snead OC III, Otsubo H.
Lateralized interictal epileptiform discharges during rapid eye movement sleep correlate with epileptogenic hemisphere in children with intractable epilepsy secondary to tuberous sclerosis complex.
Epilepsia 2011; 52: 1986-94.

Nagarajan L, Ghosh S, Palumbo L, Akiyama T, Otsubo H.
Fast activity during EEG seizures in neonates.
Epilepsy Res 2011; 97: 162-9.

Endoh F, Yoshinaga H, Ishizaki Y, Oka M, Kobayashi K, Ohtsuka Y.
Abnormal fast activity before the onset of West syndrome.
Neuropediatrics 2011; 42: 51-4.