Chemistry of Bioactive Compounds

Search and Production of Useful Bioactive Compounds

Staffs

Hiroshi KANZAKIProfessor:KANZAKI Hiroshi, Ph. D.
E-mail: hkanzaki@(@okayama-u.ac.jp)
Search and Production of Useful Bioactive Compounds Using Cells or Enzymes
Teruhiko NITODAProfessor:NITODA Teruhiko, Ph. D.
E-mail: nitoda@(@okayama-u.ac.jp)
Search for Natural Bioactive Compounds

Research Topics

Studies on novel enzymes useful for synthesizing or searching for anticancer compounds
Microbial enzyme-catalyzed high functionalization of olive constituents
Microbial synthesis or degradation of functional glycosides
High functionalization of woody biomass using microbial transformation
Search for specific inhibitors of insect enzymes
Structure-activity relationship for novel chitinolytic enzyme inhibitors
Search for compounds with insect growth regulating activity

Publications

・Biotransformation of α-mangostin by Colletotrichum sp. MT02 and Phomopsis euphorbiae K12, Arunrattiyakorn P., Suwannasai N., Aree T., Kanokmedhakul S., Ito, H., and Kanzaki H., J. Mol. Cat. B: Enz. , 102, 174-179 (2014).
・TMG-chitotriomycin as a probe for the prediction of substrate specificity of β-N-acetylhexosaminidases. Shiota H., Kanzaki H., Hatanaka T., and Nitoda T., Carbohydrate Res., 375, 29-34 (2013).
・Total synthesis of the proposed structure for pochonicine and determination of its absolute configuration. Kitamura Y., Koshino H., Nakamura H., Tsuchida A., Nitoda T., Kanzaki H., Matsuoka K., Takahashi S., Tetrahedron Lett., 54, 1456-1459 (2013).
・MS/MS fragmentation-guided search of TMG-chitooligomycins and their structure-activity relationship in specific β-N-acetylglucosaminidase inhibition. Usuki H., Yamamoto Y., Kumagai Y., Nitoda T., Kanzaki H., and Hatanaka T., Org. Biomol. Chem., 9, 2943-2951 (2011).
・Antivibrio compounds produced by Pseudomonas sp. W3: characterization and assessment of their safety to shrimps, Rattanachuay P., Kantachote D., Tantirungkij, M., Nitoda T., Kanzaki H., World J. Microbiol. Biotechnol., 27, 869-880 (2011).